<p>Breast cancer is the top cancer in women both in the developed and the developing world. For early detection of the disease, mammography is still the most effective method beside ultrasound and magnetic resonance imaging. Computer Aided Detection systems have been developed to aid radiologists in diagnosing breast cancer. Different methods were proposed to overcome the main drawback of producing large number of False Positives. In this paper, we presented a novel method for masses detection in mammograms. To describe masses, multi-resolution features were utilized. In feature extraction step, we calculated multi-resolution Block Difference Inverse Probability features and multi-resolution statistical features. Once the descriptors were extracted, we deployed random projection and distance weighted K Nearest Neighbor to classify the detected masses. The result is quite sanguine with sensitivity, false positive reduction and time for carrying out the algorithm</p>