Detection of unsuspected distant metastases and/or regional nodes by FDG-PET in LD-SCLC scan in apparent limited-disease small-cell lung cancer

The Role of Integrated 18F-FDG PET-CT as a Staging Tool for Limited-Stage Small Cell Lung Cancer: A Retrospective Study

“…Concerning the sensitivity and specificity of PET scans, most previous studies have reported a 100% sensitivity for site-specific lesions, and superior sensitivity and specificity to conventional staging work-up [3,[8][9][10][11][12][13][14][15][16][17]. Brink et al [9] reported superior sensitivity and specificity for FDG-PET compared with CT in detecting extrathoracic lymph node involvement (sensitivity 100 vs. 70%, specificity 98 vs. 94%) and distant metastases except for metastases to the brain (sensitivity 98 vs. 83%, specificity 92 vs. 79%).…”

“…However, in patients with limited-stage disease (LD), addition of thoracic radiotherapy to chemotherapy resultsingoodsurvivaloutcome,evenincure,whilechemotherapy alone is the standard of care in SCLC patients with extensive-stage disease (ED). Therefore, accurate staging is veryimportantinordertoreservetoxicbuteffectivethoracic radiotherapyforpatientswhomightbenefitfromit [1,2].On theotherhand, 18 fluoro-2-deoxy-D-glucose-positronemission tomography (18F-FDG-PET) or integrated PET-computed tomography(PET-CT)isthoughttobeveryhighlysensitive in finding small and unsuspected metastatic tumors [3]. For non-smallcelllungcancerpatients,PETorPET-CTisrecommendedtofindoccultlocoregionallesionsanddistantmetastases as this can sometimes change or influence treatment planning [4][5][6].…”

“…For non-smallcelllungcancerpatients,PETorPET-CTisrecommendedtofindoccultlocoregionallesionsanddistantmetastases as this can sometimes change or influence treatment planning [4][5][6]. However, the role of PET or PET-CT in SCLC patients has yet to be clearly defined, although it has beenthesubjectofsmallstudies [1,3,[7][8][9][10][11][12][13][14][15][16][17].Inthisretrospectivestudy,weassessedtheusefulnessoftheadditionofPET-CT as a staging tool to conventional staging procedures in patients diagnosed with LD SCLC based on conventional stagingprocedures.…”

Staging in Patients with Small-Cell Lung Carcinoma; PET-CT versus Standard Staging Procedures

“…In studies thus far, distant metastasis was detected by PET-CT on the patients of 0-33% who were staged as limited disease SCLC by SSPs (8,9,(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Seven of these studies were conducted retrospectively and 5 prospectively.…”

Use Of Pet In Radiationtreatment Planning For Thoracic Malingnancies

“…Bu çalışmada PET/BT 29 hastanın 5'inde (%17) evreyi değiştirmiş olup evrelemede doğ-ruluğu artırdığı gösterilmiştir. Diğer bir çalışmada, konvansiyonel evreleme yöntemleri ile sınırlı hastalık tespit edilen hastalarda FDG-PET/BT eklenerek yeniden yapılan evrelemede hastaların %8,3-9,5'da yaygın hastalık evresinde olduğu görülmüştür (72,73). Arslan ve ark FDG-PET/BT ve BT ile yapılan evrelemenin doğruluğu-nu ve genel sağ kalım ile ilişkisini değerlendirmişlerdir (74).…”