Detection, Quantitation and Contrast Enhancement of Myocardial Infarction Utilizing Computerized Axial Tomography: Comparison With Histochemical Staining and 99mTc-Pyrophosphate Imaging

Purpose:To develop a cardiac computed tomographic (CT) method with which to determine extracellular volume (ECV) fraction, with cardiac magnetic resonance (MR) imaging as the reference standard. Materials and Methods:Study participants provided written informed consent to participate in this institutional review board-approved study. ECV was measured in healthy subjects and patients with heart failure by using cardiac CT and cardiac MR imaging. Paired Student t test, linear regression analysis, and Pearson correlation analysis were used to determine the relationship between cardiac CT and MR imaging ECV values and clinical parameters. Results:Twenty-four subjects were studied. There was good correlation between myocardial ECV measured at cardiac MR imaging and that measured at cardiac CT (r = 0.82, P , .001). As expected, ECV was higher in patients with heart failure than in healthy control subjects for both cardiac CT and cardiac MR imaging (P = .03, respectively). For both cardiac MR imaging and cardiac CT, ECV was positively associated with end diastolic and end systolic volume and inversely related to ejection fraction (P , .05 for all). Mean radiation dose was 1.98 mSv 6 0.16 (standard deviation) for each cardiac CT acquisition. Conclusion:ECV at cardiac CT and that at cardiac MR imaging showed good correlation, suggesting the potential for myocardial tissue characterization with cardiac CT.q RSNA, 2012

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“…Scanning parameters were as follows: repetition time msec/echo time msec/minimum inversion time msec, 1. (2)(3)(4)(5)(6).…”

Section: Cardiac Mr Imaging Protocolmentioning

confidence: 99%

Interstitial Myocardial Fibrosis Assessed as Extracellular Volume Fraction with Low-Radiation-Dose Cardiac CT

et al. 2012

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“…5,6 Development of fast MR imaging techniques and groundbreaking investigations in the late 1990s and early 2000s pushed the boundaries of postcontrast imaging of myocardial infarction. 7,8 Contrast Mechanism and Imaging Sequence Techniques Underlying principles of contrast agent dynamics Basic knowledge of the pharmacokinetics of extracellular gadolinium-based contrast agents (GBCAs) is important for a better understanding of LGE imaging techniques.…”

Section: Techniques and Implementationmentioning

confidence: 99%

Late Gadolinium Enhancement Imaging in Assessment of Myocardial Viability

Juan

Crean

Wintersperger

2015

Radiologic Clinics of North America

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“…This is exhausted when critical coronary artery stenosis develops and a resting myocardial perfusion abnormality will appear with complete occlusion of the coronary artery [35] . Cardiac CT based MPI has been utilised in animals since the late 1970s but its use in detection of MI only took off in mid-2000 [36][37][38] . Resting MPI in addition to CTCA improves its diagnostic accuracy for detecting significant coronary artery disease.…”

Section: Mpimentioning

confidence: 99%

Role of cardiovascular magnetic resonance in assessment of acute coronary syndrome

Teo

Worthley

2014

WJC

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information of prognostic value such as viability which cardiovascular magnetic resonance (CMR) allows. Despite its manifold benefits, there are limitations to its wider use in routine clinical assessment and more studies are required into assessing its cost-effectiveness. It is hoped that with greater development in the technology and imaging protocols, CMR could be made less cumbersome, its imaging protocols less lengthy, the technology more inexpensive and easily applied in routine clinical practice.© 2014 Baishideng Publishing Group Inc. All rights reserved.Key words: Cardiovascular disease; Acute coronary syndrome; Cardiac imaging Core tip: This review focuses on cardiovascular magnetic resonance in achieving speedy diagnosis, risk stratification and prognostication in acute coronary syndrome. It discusses the modalities already available towards achieving this end and the incremental information availed by cardiac magnetic resonance. The paper also discusses new imaging techniques and their contribution towards the cardiac magnetic resonance imaging assessment of patients with acute coronary syndrome.Azarisman SM, Teo KS, Worthley MI, Worthley SG. Role of cardiovascular magnetic resonance in assessment of acute coronary syndrome. World J Cardiol 2014; 6(6): 405-414 Available from:

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Detection, Quantitation and Contrast Enhancement of Myocardial Infarction Utilizing Computerized Axial Tomography: Comparison With Histochemical Staining and 99mTc-Pyrophosphate Imaging

Cited by 63 publications

References 0 publications

Interstitial Myocardial Fibrosis Assessed as Extracellular Volume Fraction with Low-Radiation-Dose Cardiac CT

Interstitial Myocardial Fibrosis Assessed as Extracellular Volume Fraction with Low-Radiation-Dose Cardiac CT

Late Gadolinium Enhancement Imaging in Assessment of Myocardial Viability

Role of cardiovascular magnetic resonance in assessment of acute coronary syndrome

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