Detection rate and diagnostic accuracy of sentinel-node biopsy in early stage endometrial cancer: a prospective multicentre study (SENTI-ENDO)

Ballester, Marcos; Dubernard, Gil; Lécuru, Fabrice; Heitz, D; Mathevet, Patrice; Marret, H.; Querleu, Denis; Golfier, François; Leblanc, Éric; Rouzier, Roman; Daraı̈, Émile

doi:10.1016/s1470-2045(11)70070-5

Cited by 485 publications

(369 citation statements)

References 44 publications

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“…SLN in the PA region was detected in 5 % of patients. For each hemipelvis as a unit, the presence of SLN was correctly identified in 100 % of patients; however, at the patient level analysis, three patients with a type 2 EC had false-positive results, giving a sensitivity of 84 % and a NPV of 97 % [11].…”

Section: Cervical Injectionmentioning

confidence: 92%

“…Half-life is relatively long to allow a deferred identification of SLN, and both have a safety profile [9]. Blue dye imaging is injected before surgery, after induction of anesthesia [11]. Isotopic imaging implies an injection, ideally 18 h before surgery, with control scintigraphic images obtained with a gamma camera.…”

Section: Lymphatic Mapping Proceduresmentioning

confidence: 99%

“…Pelvic SLNs were detected in 89 % of the patients (31 % unilateral and 69 % bilateral). They explained this low detection rate with the long interval between radiocolloid injection and SLN procedure, with a median time of 22 h [11]. SLN in the PA region was detected in 5 % of patients.…”

Section: Cervical Injectionmentioning

confidence: 99%

“…The primary goal of SLN in EC consists in reducing the morbidity of a full lymphadenectomy (by decreasing surgical time), as well as early (need of blood transfusion, fever, wound infection, thromboembolism [10]) and late complications (lymphocysts formation, leg lymphedema, transient neuralgias [3,6,[8][9][10][11][12][13][14]). Besides, SLN allows an accurate exploration of all drainage routes as well as those considered aberrant or not routinely examined [12].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the use of more sensitive techniques for SLN detection could better identify pelvic nodes and probably reduce the reported incidence of isolated infra-renal metastasis [8]. The secondary goal is to improve detection of micrometastasis, which is associated with a recurrence risk [13], with resource to ultra-sectioning and immunohistochemestry (IHC) protocols [3,6,[8][9][10][11][12][13]. Therefore, the risk of recurrence related to positive lymph nodes missing despite a full lymphadenectomy could be reduced [12], and SLN could improve selection of patients for adjuvant therapy.…”

Section: Introductionmentioning

confidence: 99%

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Sentinel lymph node in endometrial cancer: an overview

2013

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The role of complete pelvic and para-aortic lymphadenectomy in early endometrial cancer remains controversial in gynecologic oncology. Sentinel lymph node detection is an alternative to assess lymphatic spread in several solid tumors. The authors review the literature related to the detection of sentinel lymph node in endometrial cancer, the techniques employed, and its results and feasibility. The authors review reported case series of endometrial cancer in which the sentinel lymph node biopsy was performed. A systematic literature review was conducted using the PubMed database. Different techniques were used considering lymphatic imaging mapping (colorimetric, isotopic, and fluorescence procedures) and injection site (subserous, hysteroscopic, and cervical). Detection rates of sentinel lymph node were heterogeneous, varying between 44 and 100 % with false-negative rates between 0 and 33 %. Although technically demanding, hysteroscopy approach was associated with the highest detection rate. The largest trials showed a good detection rate with cervical injection, a more reproducible procedure. The laparoscopic route improved the results. Immunohistochemistry staining improved the micrometastasis detection in sentinel lymph node. Cost-effectiveness of systematic lymphadenectomy compared with sentinel lymph node procedure and its value on adjuvant therapies as well as a standardized reproducible and reliable technique must be assessed.

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Section: Cervical Injectionmentioning

confidence: 92%

Section: Lymphatic Mapping Proceduresmentioning

confidence: 99%

Section: Cervical Injectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sentinel lymph node in endometrial cancer: an overview

2013

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Assessment of Sentinel Lymph Node Biopsy vs Lymphadenectomy for Intermediate- and High-Grade Endometrial Cancer Staging

et al. 2021

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IMPORTANCE Whether sentinel lymph node biopsy (SLNB) can replace lymphadenectomy for surgical staging in patients with high-grade endometrial cancer (EC) is unclear. OBJECTIVE To examine the diagnostic accuracy of, performance characteristics of, and morbidity associated with SLNB using indocyanine green in patients with intermediateand high-grade EC. DESIGN, SETTING, AND PARTICIPANTS In this prospective, multicenter cohort study (Sentinel Lymph Node Biopsy vs Lymphadenectomy for Intermediate-and High-Grade Endometrial Cancer Staging [SENTOR] study), accrual occurred from July 1, 2015, to June 30, 2019, with early stoppage because of prespecified accuracy criteria. The study included patients with clinical stage I grade 2 endometrioid or high-grade EC scheduled to undergo laparoscopic or robotic hysterectomy with an intent to complete staging at 3 designated cancer centers in Toronto

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