Deteksi Dini Karsinoma Sel Basal

Tan, Sukmawati Tansil; Ghaznawie, Mahmud; Reginata, Gabriela

doi:10.33371/ijoc.v10i2.428

Cited by 6 publications

(12 citation statements)

References 13 publications

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“…BCC is the most common epithelial malignancy in humans 75-80% of nonmelanoma cancers. [1][2][3][4][5][6] BCC is four to five times more common than squamous cell carcinoma. 24 Incidence is highest in Australia and lowest in parts of Africa.…”

Section: Discussionmentioning

confidence: 99%

“…In accordance with the existing literature, BCC often occurs in the elderly, aged between 50-80 years, with an average of about 65 years. 1,4,11,12 Increasing age will increase the risk of cumulative UV exposure and decrease the capacity and ability to repair DNA damage. 19 The reduced density of skin melanocytes in the elderly also leads to more extension of UV penetration into the dermis causing more extensive damage.…”

Section: Discussionmentioning

confidence: 99%

“…7 BCC often occurs in the elderly, aged between 50-80 years, with a mean of about 65 years. 1,4,11,12 The incidence of this carcinoma will increase significantly with increasing age.2,11 This increase in incidence is greatest significantly found in young women in Europe (Netherlands and Denmark) and the United States with the ratio of women more than men compared to the older population (where there are more men than women). The difference in this ratio occurs due to the high use of tanning beds by young women (tanning baths are a tool to get a brown skin color by involving a device that emits ultraviolet radiation).9, 12 The ratio of males to females affected is usually around 1.5-2 :1.2, 12 Exposure to ultraviolet (UV) light is a major risk factor for BCC.…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between Clinicopatological Data With Basal Cell Carcinoma Histopathology Subtypes

Sundoro¹,

Alferraly²,

Delyuzar³

et al. 2021

IJRP

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Background: Basal cell carcinoma (BCC) is an epithelial malignancy most commonly found in human about 75-80% of non-melanoma cancer. At the moment, BCC has been one of the most important health problems, due to increasing number of incidents. Studies about the relationship between clinicopathologic data and histopathologic subtypes of BCC in Indonesia especially in Medan are still limited. Therefore, the researchers are interested in this study. Objective: To analyze the relationship between clinicopathologic data and histopathologic subtypes of BCC. Methods: A cross-sectional study was performed using formalin-fixed tissue paraffin blocks from 38 BCC patients. Clinical data such as age, gender, occupation, ethnic groups, tumour location and size were recorded. Then, each BCC cases were reviewed for determining histopathologic subtypes of BCC. Then, the relationship between clinicopathologic data and histopathologic subtypes in BCC was assassed and analyzed with statistical software by using the chi-square test or fisher exact test. Results and Discussion: About 68.4% samples aged > 60 years old; 57.9% women; 36.8% housewives; 44.7% located in mid face, mostly in palpebra; 50% with size of ≥1.5cm; 78.9% nodular BCC; and 89.5% with lower recurrence risks. Men tend to have BCC than women because they smoke more and tend to work outdoor. That's why they are more exposed to UV rays. These factors are thought to trigger tumour growth. Conclussion: There were no statistically significant relationships between age, gender, occupations, ethnic, tumour location and size with histopathologic subtypes of BCC

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship Between Clinicopatological Data With Basal Cell Carcinoma Histopathology Subtypes

Sundoro¹,

Alferraly²,

Delyuzar³

et al. 2021

IJRP

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“…Sumatera Barat adalah salah satu provinsi yang dilalui garis khatulistiwa; angka kejadian kanker kulit cukup tinggi karena paparan radiasi ultraviolet B sinar matahari merupakan faktor penyebab utama karsinoma sel basal. 6,12 Berdasarkan data status rekam medis RSUP Dr. M. Jamil Padang dari Januari 2017 hingga Januari 2018 didapatkan 41 kunjungan poli Onkologi dengan diagnosis kanker kulit. Dari 41 kunjungan itu, 17 kasus (41,4%) karsinoma sel basal, 14 kasus (34,1%) karsinoma sel Gambar 6.…”

Section: Pembahasanunclassified

Eksisi Luas dan Rekonstruksi Karsinoma Sel Basal Wajah

HD¹,

WA²,

Khambri³

et al. 2022

CDK

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Pembedahan adalah terapi paling efektif untuk karsinoma sel basal (KSB). Meskipun sangat jarang bermetastasis, KSB menyebabkan destruksi lokal luas mencakup kerusakan jaringan lunak, kartilago, dan tulang, sehingga memerlukan penanganan lebih komprehensif termasuk rekonstruksi. Tulisan ini melaporkan tata laksana kasus serial karsinoma sel basal di RSUP Dr. M. Djamil Padang periode Januari hingga Mei 2020.Surgical treatment is the most effective treatment in basal cell carcinoma (BCC). Although metastasis is rarely found, basal cell carcinoma causes extensive local destruction including soft tissue, cartilage, and bone damage requiring more comprehensive treatment including reconstruction. A series of basal cell carcinoma cases management in Dr. M. Djamil General Hospital Padang during January to May 2020 was reported.

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“…Skin is a vital organ that reflects human health. The skin is a complex, elastic, and sensitive organ (Tan, Ghaznawie, & Reginata, 2016). Human skin has various essential functions for the body, primarily to protect the body from external elements (Sagoyo, Widodo, & Dachlan, 2017).…”

Section: Introductionmentioning

confidence: 99%

Anti-PD-L1 Therapy as a Solution for Non-Melanoma Skin Cancer Basal Cell Carcinoma

Situmeang

Kyong

Purba

et al. 2022

BES

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Skin cancer is a disease that can cause the loss of the ability to regenerate and protect the skin normally. The types of skin cancer that are known are melanoma and non-melanoma skin cancer. Non-melanoma Basal cell carcinoma is a malignant neoplasm originating from non-keratinizing cells in the basal layer of the skin's epidermis. The treatment itself is carried out through the application of immunotherapy, namely the use of drug therapy Programmed Death Ligand 1 (PD-L1). This study aims to see the effectiveness of PD-L1 Therapy as a treatment for basal cell carcinoma. The focus of the study of the article is the integument system, skin cancer, non-melanoma basal cell carcinoma, and the effect of anti-PD-L1 use. The research method used is a literature review from various sources. Skin cancer Basal cell carcinoma attacks the basal cells of the epidermis, causing disruption. Attacks slowly, but when ignored will spread wider and more severe. Through PD-L1 therapy by binding to PD-1 receptors on immune cells, it causes the activation of T lymphocytes as anti-cancer cells in the body that suppress growth while actively controlling tumor cells. Through the use of PD-L1 therapy in treating cancer that attacks basal cells, it will suppress growth, destroy and shrink cancer cells, and increase the body's immunity against cancer cells.

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Deteksi Dini Karsinoma Sel Basal

Cited by 6 publications

References 13 publications

Relationship Between Clinicopatological Data With Basal Cell Carcinoma Histopathology Subtypes

Relationship Between Clinicopatological Data With Basal Cell Carcinoma Histopathology Subtypes

Eksisi Luas dan Rekonstruksi Karsinoma Sel Basal Wajah

Anti-PD-L1 Therapy as a Solution for Non-Melanoma Skin Cancer Basal Cell Carcinoma

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