Covid-19 pandemic attacking the world has paralyzed the economy. Indonesia is one of the affected countries. One of the sectors affected is MSMEs. Most Indonesian MSMEs have been significantly impacted during the Covid-19 pandemic. Measures to overcome the outbreak require at least five related parties, i.e., academics, business actors, communities, government, and social media, better known as the Pentahelix model. This study aimed to acquire information on a comprehensive picture of the synergism of the driving force of Pentahelix to improve the performance of MSME management in Serang City, Banten Province, Indonesia. The study object was MSMEs in Serang City, Banten. The instrument used was a questionnaire. The data analysis technique was Partial Least Square using SmartPLS software. The results demonstrated that the R Square (R2) value was 0.799. Hypothesis testing showed that academics did not affect management performance, with a coefficient value of 0.366. Business actors had a positive effect on management performance, with a coefficient value of 0.511. The community positively affected management performance, with a coefficient value of 0.449. The government did not affect management performance, with a coefficient value of -0.438, and Social Media did not affect management performance, with a coefficient value of 0.027.