Abstract:Many theories of cerebellar function assume that longterm depression (LTD) of parallel fiber (PF) synapses enables Purkinje cells (PCs) to learn to recognize PF activity patterns. According to the classic view, a PC can store and learn to distinguish PF activity patterns that have been presented repeatedly together with climbing fibre (CF) input to the cell. The resulting LTD of the PF synapses is often assumed to lead to a decreased rate of PC simple spike firing, a reduction in the inhibition of their target… Show more
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