Determinants of Spatial and Temporal Coding by Semicircular Canal Afferents

Highstein, Stephen M.; Rabbitt, Richard D.; Boyle, Richard D.

doi:10.1152/jn.00533.2004

Cited by 54 publications

(51 citation statements)

References 88 publications

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“…Therefore, the membrane has to be replaced regularly and T c must be determined before every experiment. The calibration test makes use of the well-known phenomenon (Grant and Van Buskirk, 1976;Highstein et al, 2005) that a deflected cupula in a SCC at rest relaxes according to (7) y c ∼ e −t/Tc .…”

Section: Resultsmentioning

confidence: 99%

In vitro model of a semicircular canal: Design and validation of the model and its use for the study of canalithiasis

Obrist

Hegemann

Kronenberg

et al. 2010

Journal of Biomechanics

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Section: Resultsmentioning

confidence: 99%

In vitro model of a semicircular canal: Design and validation of the model and its use for the study of canalithiasis

Obrist

Hegemann

Kronenberg

et al. 2010

Journal of Biomechanics

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“…Previous studies have shown a strong inverse correlation between the sensitivity at the spike-initiation site of vestibular-nerve afferents and their regularity of background discharge rate (Goldberg et al 1984;Baird et al 1988;Highstein et al 2005). This post-synaptic gain has been shown in the chinchilla to be at least an order of magnitude greater in "calyx-only" afferents than in afferents that are more regularly discharging (Baird et al 1988).…”

Section: Responses At 2 Hzmentioning

confidence: 99%

Rotational Responses of Vestibular–Nerve Afferents Innervating the Semicircular Canals in the C57BL/6 Mouse

Lasker

Han

Park

et al. 2008

JARO

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Extracellular recordings were made from vestibularnerve afferents innervating the semicircular canals in anesthetized C57BL/6 mice ranging in age from 4-24 weeks. A normalized coefficient of variation was used to divide afferents into regular (CV*G0.1) and irregular (CV*90.1) groups. There were three overall conclusions from this study. First, mouse afferents resemble those of other mammals in properties such as resting discharge rate and dependence of response dynamics on discharge regularity. Second, there are differences in mouse afferents relative to other mammals that are likely related to the smaller size of the semicircular canals. The rotational sensitivity of mouse afferents is approximately threefold lower than that reported for afferents in other mammals. One consequence of the lower sensitivity is that mouse afferents have a larger linear range for encoding head velocity. The long time constant of afferent discharge, which is a measure of low-frequency response dynamics, is shorter in mouse afferents than in other species. Third, juvenile mice (age 4-7 weeks) appear to lack a class of low-sensitivity, highly irregular afferents that are present in adult animals (age 10-24 weeks). By analogy to studies in the chinchilla, these irregular afferents with low sensitivities for lower rotational frequencies correspond to calyx-only afferents. These findings suggest that, although the calyx ending on to type I hair cells is morphologically complete in mice by the age of about 1 month, the physiological response properties in these juvenile animals are not equivalent to those in adults.

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“…Despite the co-variation between response dynamics and regularity, it is generally argued that they arise from distinct mechanisms. Variation in response dynamics is attributed to mechanical factors, affecting the input to hair cell transduction channels and hair cell processes (for a review, see Eatock and Lysaksowski, 2006), which may include synaptic mechanisms (Highstein et al, 2005). As we shall discuss, factors determining firing regularity are held to be postsynaptic, with speculation centered on the morphology of afferent dendrites and on ion channels (Highstein and Politoff, 1978;Smith and Goldberg, 1986) (for a review, see Goldberg, 2000).…”

Section: Firing Regularitymentioning

confidence: 99%

Ion channels in mammalian vestibular afferents may set regularity of firing

Eatock

Xue

Kalluri

2008

Journal of Experimental Biology

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SummaryRodent vestibular afferent neurons offer several advantages as a model system for investigating the significance and origins of regularity in neuronal firing interval. Their regularity has a bimodal distribution that defines regular and irregular afferent classes. Factors likely to be involved in setting firing regularity include the morphology and physiology of the afferents' contacts with hair cells, which may influence the averaging of synaptic noise and the afferents' intrinsic electrical properties. In vitro patch clamp studies on the cell bodies of primary vestibular afferents reveal a rich diversity of ion channels, with indications of at least two neuronal populations. Here we suggest that firing patterns of isolated vestibular ganglion somata reflect intrinsic ion channel properties, which in vivo combine with hair cell synaptic drive to produce regular and irregular firing.

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Determinants of Spatial and Temporal Coding by Semicircular Canal Afferents

Abstract: . Determinants of spatial and temporal coding by semicircular canal afferents.

Cited by 54 publications

References 88 publications

In vitro model of a semicircular canal: Design and validation of the model and its use for the study of canalithiasis

In vitro model of a semicircular canal: Design and validation of the model and its use for the study of canalithiasis

Rotational Responses of Vestibular–Nerve Afferents Innervating the Semicircular Canals in the C57BL/6 Mouse

Ion channels in mammalian vestibular afferents may set regularity of firing

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