Determination and Evaluation of Bioavailability of Vitamins from Different Multivitamin Supplements Using a Pig Model

Yang, Peilong; Wang, Huakai; Li, Longxian; Zhang, Nan; Ma, Yongxi

doi:10.3390/agriculture11050418

Cited by 4 publications

(3 citation statements)

References 33 publications

(41 reference statements)

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“…The volume of distribution at steady state (V SS ) was determined as V SS = MRT IV × Cl. For PO administration, the peak concentration of danofloxacin (C max ) and the time to reach it (T max ) were both directly read from the concentration versus time curve [ 16 ]. The mean absorption time (MAT) was calculated as MRT PO minus MRT IV .…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetics of Danofloxacin in Gushi Chickens after Single Oral and Intravenous Administration

Chen

Li²,

Duan

et al. 2023

Metabolites

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This study aimed to determine the pharmacokinetics of danofloxacin in Gushi chickens after a single oral (PO) and intravenous (IV) dose at 5 mg/kg body weight (BW). Thirty-two Gushi chickens, aged 20 weeks, were selected and divided into two groups at random, with each group consisting of 16 chickens, evenly distributed between males and females. Following danofloxacin administration, blood samples were taken at predetermined time intervals and the plasma was separated. The concentrations of danofloxacin in plasma were quantified by HPLC with a fluorescence detector. Then the concentrations versus time data were subjected to non-compartmental analysis (NCA) using Phoenix software (version: 8.1.0). After administering danofloxacin orally at a dose of 5 mg/kg BW to Gushi chickens, our results demonstrated that the peak concentration reached 0.53 μg/mL at 4 h. The half-life of absorption (t1/2ka) was determined to be 2.37 ± 1.60 h, and the bioavailability (F) was calculated as 40.12 ± 15.83%. For both oral and intravenous administration, the area under the concentration–time curve (AUC0-∞) was determined to be 4.72 ± 1.86 and 11.76 ± 3.25 h·µg/mL, respectively. The corresponding elimination half-life (t1/2λz) was measured as 11.24 ± 3.90 and 10.17 ± 3.72 h. Moreover, the mean residence time (MRT) was calculated as 10.20 ± 2.47 and 7.05 ± 1.97 h for these respective routes. Based on the calculated AUC/MIC ratio values, it can be inferred that the 5 mg/kg BW dosage of danofloxacin, whether administered orally or intravenously, is expected to effectively treat Escherichia coli and Pasteurella multocida infections in Gushi chickens.

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Section: Methodsmentioning

confidence: 99%

Pharmacokinetics of Danofloxacin in Gushi Chickens after Single Oral and Intravenous Administration

Chen

Li²,

Duan

et al. 2023

Metabolites

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show abstract

“…The limited consumption of fruits and vegetables as a source of vitamins and key nutrients contrasts with the recent surge in internet searches about vitamins exacerbated by the COVID-19 epidemic [22]. Often the bioavailability of key nutrients in F&V surpasses that of supplements [23], although the issue is complex and requires additional research [24]. In the meantime, Turkish consumers can enjoy the abundant domestic supply of fresh produce and bene t from the established link between its consumption and disease prevention and health maintenance.…”

Section: Fruit and Vegetable Consumption And Nutrient De Ciency In Tu...mentioning

confidence: 99%

Fruit and Vegetable Consumption across Population Segments: Evidence from a National Household Survey

Küçük

Urak

Bilgiç

et al. 2023

Preprint

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Background The 2002 World Health Report documented that low fruit and vegetable intake are among the top ten risk factors contributing to attributable mortality and up to three million lives could be saved each year by adequate consumption of F&V across the globe, leading an examination of behavioral preferences of the individual and family social, environmental, and behavioral factors that constitute perceived barriers to fruit and vegetable consumption. ObjectiveThe study examines factors affecting the choice of eating fruits and vegetables by household members and calculates eating frequency probabilities of different population-origin associated with personal attributes and behavior. Method Turkish Health Survey (THS) 2019 data from the Turkish Statistical Institute (TSI) national representative household panel is applied. Estimating a random-effect bivariate probit model of fruit and vegetable choice, we calculated marginal probabilities of choosing fruits and vegetables, the joint probability of choosing both, and conditional probabilities between choosing to eat either, detecting consumption synergy. Results The role of uncontrolled variables in choosing to eat fruits and vegetable (F&V) differs between the decision of an average family and the decision of individual family members. While the attitude is positive for an average family, it is negative among family members. Most individual and family attributes inversely affect fruit and vegetable choice across different groups, while a positive causal relationship exists between the likelihood of fruit and vegetable choice and attributes such as age, marital status, education, weight, having health insurance, income, and time and forms of physical activity. Conclusion and recommendation Instead of a general policy for the implementation of a healthy and balanced nutrition program to improve fruit and vegetable eating frequency, it appears more effective to adopt programs with distinct characteristics that segregate society into different cohorts. We suggest appropriate policies and offer suitable approaches to reach targeted groups.

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“…The limited consumption of fruits and vegetables as a source of vitamins and key nutrients contrasts with the recent surge in internet searches about vitamins exacerbated by the COVID-19 epidemic [ 22 ]. Often the bioavailability of key nutrients in F&V surpasses that of supplements [ 23 ], although the issue is complex and requires additional research [ 24 ]. In the meantime, Turkish consumers can enjoy the abundant domestic supply of fresh produce and benefit from the established link between its consumption and disease prevention and health maintenance.…”

Section: Introductionmentioning

confidence: 99%

Fruit and vegetable consumption across population segments: evidence from a national household survey

Küçük

Urak²,

Bilgiç

et al. 2023

J Health Popul Nutr

View full text Add to dashboard Cite

Background The 2002 World Health Report documented that low fruit and vegetable intake are among the top ten risk factors contributing to attributable mortality and up to three million lives could be saved each year by adequate consumption of F&V across the globe, leading an examination of behavioral preferences of the individual and family social, environmental, and behavioral factors that constitute perceived barriers to fruit and vegetable consumption. Objective The study examines factors affecting the choice of eating fruits and vegetables by household members and calculates eating frequency probabilities of different population-origin associated with personal attributes and behavior. Method Turkish Health Survey (THS) 2019 data from the Turkish Statistical Institute (TSI) national representative household panel is applied. Estimating a random-effect bivariate probit model of fruit and vegetable choice, we calculated marginal probabilities of choosing fruits and vegetables, the joint probability of choosing both, and conditional probabilities between choosing to eat either, detecting consumption synergy. Results The role of uncontrolled variables in choosing to eat fruits and vegetable (F&V) differs between the decision of an average family and the decision of individual family members. The attitude is positive for an average family and contrasts with the negative attitude among some family members. Most individual and family attributes inversely affect fruit and vegetable choice across different groups, while a positive relationship exists between the likelihood of fruit and vegetable choice and attributes such as age, marital status, education, weight, having health insurance, income, and time and forms of physical activity. Conclusion and recommendation Instead of a general policy for the implementation of a healthy and balanced nutrition program to improve fruit and vegetable eating frequency, it appears more effective to adopt programs with distinct characteristics that segregate society into different cohorts. We suggest appropriate policies and offer suitable approaches to reach targeted groups.

show abstract

Determination and Evaluation of Bioavailability of Vitamins from Different Multivitamin Supplements Using a Pig Model

Cited by 4 publications

References 33 publications

Pharmacokinetics of Danofloxacin in Gushi Chickens after Single Oral and Intravenous Administration

Pharmacokinetics of Danofloxacin in Gushi Chickens after Single Oral and Intravenous Administration

Fruit and Vegetable Consumption across Population Segments: Evidence from a National Household Survey

Fruit and vegetable consumption across population segments: evidence from a national household survey

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