Determination of 1-phenyl-2-propanone (P2P) by HS-GC/MS in a material sold as “wet amphetamine”

Arnoldi, Sebastiano; Roda, Gabriella; Coceanig, Alessandro; Casagni, Eleonora; Dell’Acqua, Lucia; Farè, Fiorenza; Rusconi, Chiara; Tamborini, Lucia; Visconti, Giacomo Luca; Gambaro, Veniero

doi:10.1007/s11419-016-0311-3

Cited by 5 publications

(13 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Each is represented by a unique letter that is also used in the following paragraphs. Dimethoxymethylbenzene (B) was not reported as an impurity up to now and is likely an artefact that is formed in the GC instrument from benzaldehyde, which was found in ATS samples before,31,32,37,38 and the GC solvent methanol. The pH of the aqueous phase has an important influence on this equilibrium since acidic compounds will show an increased solubility in alkaline waste samples.…”

mentioning

confidence: 99%

“…The pH of the aqueous phase has an important influence on this equilibrium since acidic compounds will show an increased solubility in alkaline waste samples. 40-42 1-phenyl-1,2-propanedione (H) was reported in 2 studies of methamphetamine, 32,34 1 amphetamine analysis,37 and the profiling of BMK 42. The performance of the SPE was therefore checked by comparing the chromatograms of the SPE extracts of batch 12 with the chromatograms of the corresponding organic phases.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Characterisation of aqueous waste produced during the clandestine production of amphetamine following the Leuckart route utilising solid‐phase extraction gas chromatography–mass spectrometry and capillary electrophoresis with contactless conductivity detection

Hauser

Hulshof

Rößler

et al. 2018

Drug Testing and Analysis

View full text Add to dashboard Cite

Chemical waste from the clandestine production of amphetamine is of forensic and environmental importance due to its illegal nature which often leads to dumping into the environment. In this study, 27 aqueous amphetamine waste samples from controlled Leuckart reactions performed in Germany, the Netherlands, and Poland were characterised to increase knowledge about the chemical composition and physicochemical characteristics of such waste. Aqueous waste samples from different reaction steps were analysed to determine characteristic patterns which could be used for classification. Conductivity, pH, density, ionic load, and organic compounds were determined using different analytical methods. Conductivity values ranged from 1 to over 200 mS/cm, pH values from 0 to 14, and densities from 1.0 to 1.3 g/cm . A capillary electrophoresis method with contactless conductivity detection (CE-C D) was developed and validated to quantify chloride, sulphate, formate, ammonium, and sodium ions which were the most abundant ions in the investigated waste samples. A solid-phase extraction sample preparation was used prior to gas chromatography-mass spectrometry analysis to determine the organic compounds. Using the characterisation data of the known samples, it was possible to assign 16 seized clandestine waste samples from an amphetamine production to the corresponding synthesis step. The data also allowed us to draw conclusions about the synthesis procedure and used chemicals. The presented data and methods could support forensic investigations by showing the probative value of synthesis waste when investigating the illegal production of amphetamine. It can also act as starting point to develop new approaches to tackle the problem of clandestine waste dumping.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Characterisation of aqueous waste produced during the clandestine production of amphetamine following the Leuckart route utilising solid‐phase extraction gas chromatography–mass spectrometry and capillary electrophoresis with contactless conductivity detection

Hauser

Hulshof

Rößler

et al. 2018

Drug Testing and Analysis

View full text Add to dashboard Cite

show abstract

“…Applying the conditions previously developed [10], we were able to obtain peaks with a good shape and a good chromatographic response either for P2P or for the IS (acetophenone). On the other hand, we were interested in increasing sensitivity in order to reach a LOD suitable for the analysis of impurities in drugs of abuse.…”

Section: Resultsmentioning

confidence: 99%

“…Incubation time and temperature: In the preliminary analysis [10], the incubation temperature was set at 80°C and the incubation time was 15 min. To favor the transition to the vapor phase of P2P, thus increasing extraction efficiency, we tested an increase of the incubation time (30 min) and an increase of the incubation temperature (100°C).…”

Section: Optimization Of Dhs Parametersmentioning

confidence: 99%

See 1 more Smart Citation

Validation Study of Analysis of 1-Phenyl-2-Propanone in Illicit Methamphetamine Samples by Dynamic Headspace Gas Chromatography Mass Spectrometry

Arnoldi¹,

Roda²,

Casagni³

et al. 2016

J Chromatogr Sep Tech

View full text Add to dashboard Cite

Capacitive sensing of an amphetamine drug precursor in aqueous samples: Application of novel molecularly imprinted polymers for benzyl methyl ketone detection

Rycke

Trynda

Jaworowicz

et al. 2021

Biosensors and Bioelectronics

View full text Add to dashboard Cite

Highly selective molecularly imprinted polymers (MIPs) towards benzyl methyl ketone (BMK) were synthesized for application as recognition elements in a capacitive sensor. A computational approach was employed to select the most appropriate monomers and crosslinkers. Using the selected compounds, different polymerization techniques and protocols were compared in order to study the effect on the MIP performance and characteristics. MIPs synthesized by bulk polymerization using itaconic acid and 1-vinylimidazole as monomers and p-divinylbenzene as cross-linker possess the highest affinity towards the target analyte. Prior to capacitive analysis, the developed particles were immobilized on the surface of gold transducers using tyramine as a linker. The validity of the developed sensor was checked by the BMK detection in spiked tap water and real water samples. A linear working range from 50-1000 µM was found while the limit of detection (LOD) was determined to be 1 µM in tap water. To the best of our knowledge, both the developed MIPs towards BMK and the electrochemical sensor for its detection have not been published or marketed to date.

show abstract

Determination of 1-phenyl-2-propanone (P2P) by HS-GC/MS in a material sold as “wet amphetamine”

Cited by 5 publications

References 10 publications

Characterisation of aqueous waste produced during the clandestine production of amphetamine following the Leuckart route utilising solid‐phase extraction gas chromatography–mass spectrometry and capillary electrophoresis with contactless conductivity detection

Characterisation of aqueous waste produced during the clandestine production of amphetamine following the Leuckart route utilising solid‐phase extraction gas chromatography–mass spectrometry and capillary electrophoresis with contactless conductivity detection

Validation Study of Analysis of 1-Phenyl-2-Propanone in Illicit Methamphetamine Samples by Dynamic Headspace Gas Chromatography Mass Spectrometry

Capacitive sensing of an amphetamine drug precursor in aqueous samples: Application of novel molecularly imprinted polymers for benzyl methyl ketone detection

Contact Info

Product

Resources

About