Determination of 60 elements in whole blood by sector field inductively coupled plasma mass spectrometry

Rodushkin, Ilia; Ödman, Fredrik; Olofsson, Rickard; Axelsson, Mikael D.

doi:10.1039/b003561k

Cited by 149 publications

(87 citation statements)

References 31 publications

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“…Wall atomization, H 2 O 2 as modifier and standard addition method for calibration are recommended. Detection limits achieved by the proposed procedure are very close to the detection limits obtained by the SF ICP-MS [26,27].…”

Section: Discussionsupporting

confidence: 59%

On chromium direct ETAAS determination in serum and urine

et al. 2007

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A simple, accurate and reliable method for direct electrothermal atomic absorption spectrometric (ETAAS) determination of chromium in serum and urine samples without any preliminary sample pretreatment is described. Instrumental parameters are optimized in order to define: the most suitable atomizer, optimal temperature program and efficient modifier. An appropriate quantification method is proposed taking into account a matrix interference study. Pyrocoated graphite tubes and wall atomization, pretreatment temperature of 700• C, atomization temperature of 2600 • C, hydrogen peroxide as modifier and standard addition calibration are recommended. The accuracy of the method proposed for Cr determination in serum and urine was confirmed by comparative analysis of parallel samples after wet or dry ashing as well as by the analysis of two certified reference materials: Serum, Clin Rep 1 and Lypochek Urine, level 1. The detection and determination limits achieved for both matrices are 0.08 µg/L and 0.15 µg/ L respectively. The relative standard deviation varied between 15 and 18 % for the chromium content in the samples in the range 0.08-0.2 µg/L and between 4 and 7 % for the chromium content in the range 0.2-2.0 µg /L for both matrices.

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Section: Discussionsupporting

confidence: 59%

On chromium direct ETAAS determination in serum and urine

et al. 2007

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“…Thus, this technique has gained popularity recently for the determination of trace elements and/or their isotope ratios in biological fluids. [6][7][8][9][10][11][12][13][14] Detection limits in the range 12 to 100 pg ml 21 for V in biological fluids have been reported using HR-ICP-MS. 9,10,12,14 In 2001, ThermoFinnigan released software, version 2.1, highlighting new mass offset and lock mass features, which permit correction for mass shift (due to hysteresis within the magnet material) and mass drift (due mostly to thermal effects) previously observed with both their Element 1 and Element 2 HR-ICP-MS insturments. These improvements not only eliminate the need for repeat mass calibrations during daily operation, especially at medium and high resolution, but also provide more stable instrument performance, resulting an improved accuracy and precision of analytical results.…”

Section: Introductionmentioning

confidence: 99%

Determination of vanadium in biological fluids using HR-ICP-MS

Yang

Sturgeon

Prince³

et al. 2002

J. Anal. At. Spectrom.

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Access and use of this website and the material on it are subject to the Terms and Conditions set forth at Determination of vanadium in biological fluids using HR-ICP-MS NRC Publications Record / Notice d'Archives des publications de CNRC:http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/ctrl?action=rtdoc&an=8899905&lang=en http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/ctrl?action=rtdoc&an=8899905&lang=fr READ THESE TERMS AND CONDITIONS CAREFULLY BEFORE USING THIS WEBSITE.http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/jsp/nparc_cp.jsp?lang=en Vous avez des questions? Nous pouvons vous aider. Pour communiquer directement avec un auteur, consultez la première page de la revue dans laquelle son article a été publié afin de trouver ses coordonnées. Si vous n'arrivez pas à les repérer, communiquez avec nous à PublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. Questions? Contact the NRC Publications Archive team atPublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. If you wish to email the authors directly, please see the first page of the publication for their contact information. NRC Publications Archive Archives des publications du CNRCThis publication could be one of several versions: author's original, accepted manuscript or the publisher's version. / La version de cette publication peut être l'une des suivantes : la version prépublication de l'auteur, la version acceptée du manuscrit ou la version de l'éditeur. For the publisher's version, please access the DOI link below./ Pour consulter la version de l'éditeur, utilisez le lien DOI ci-dessous.http://doi.org/10.1039/b207563fJournal of Analytical Atomic Spectrometry, 17, 10, pp. 1300Spectrometry, 17, 10, pp. -1303Spectrometry, 17, 10, pp. , 2002 Determination of vanadium in biological fluids using HR-ICP-MS A simple, fast and sensitive method is described for the determination of vanadium in biological fluids using high resolution inductively coupled plasma mass spectrometry (HR-ICP-MS). Samples were diluted 20-fold in 0.3% HNO 3 . Spectral interference from 35 Cl 16 O 1 , present in urine or serum matrices, was completely resolved from the vanadium major isotope of 51 V 1 at medium resolution of 4000. Quantitation of V in urine and serum was achieved by the method of additions using standards prepared in a pooled urine or serum sample. Mass offset and lock mass ( 40 Ar 16 O 1 ) options were employed for more accurate and precise results. Better than 2.0% RSD was obtained with a 200 pg ml 21 V spike added to a 20-fold diluted urine or serum matrix, reflecting one day stability. Vanadium concentrations in the range of v10 to 1500 pg ml 21 and v10 to 760 pg ml 21 were determined in the urine and serum samples, respectively. Good day-to-day precision of less than 4.0% RSD was typical for both sample matrices. Spike recoveries of 99 ¡ 2 and 98 ¡ 3% (one standard deviation, n~3) were obtained in the urine and serum, respectively. An in-house CRM (SLRS-4: river water) was analyzed daily, yielding a V concentration of 0.337 ¡ 0.010 ng ml 21 (one standard deviati...

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“…The improved limit of quantification after extraction thus results from the use of a greater proportion of the initial sample volume for ethylation (30% is used routinely, although Ͼ90% is possible). Semiquantitative analyses of aqueous back-extracts, performed by high resolution ICPMS (18,19 ), proved the efficacy of the clean-up procedure, because only 6 elements of Ͼ60 monitored were consistently found at concentrations corresponding to Ͼ1 mg/L in blood. Of these, Br, K, S, and Cu (at ϳ60, ϳ10, ϳ6, and ϳ3 mg/L, respectively) likely originate from reagents added to the blood, and Cl (at the percentage level) derives from residual dichloromethane in the aqueous phase.…”

Section: Resultsmentioning

confidence: 99%

“…The resulting solutions were enriched to 25 g/L with internal standard solution containing In and Tl. Total elemental concentrations were determined by ICPMS with a high-resolution instrument (Element, Thermo Finnigan), as detailed elsewhere (18,19 ). Quality control was achieved by routine analysis of certified reference materials and regular participation in international quality assessment programs since 1998 (20 ).…”

Section: Materials and Methods Instrumentationmentioning

confidence: 99%

Methylmercury Measurement in Whole Blood by Isotope-Dilution GC-ICPMS with 2 Sample Preparation Methods

Baxter¹,

Rodushkin²,

Klockare³

et al. 2007

Clinical Chemistry

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Background: Despite its known toxicity, methylmercury is rarely measured directly in clinical studies; instead, conclusions are based on total mercury measurements. We have developed isotope-dilution-based methods for methylmercury-specific analysis of whole blood by coupled gas chromatography-inductively coupled plasma mass spectrometry (GC-ICPMS). Methods: We analyzed animal and human blood samples after alkaline digestion or extraction of methylmercury into dichloromethane and back extraction into water. Methylmercury was converted to the volatile ethyl derivative, purged, and trapped on a solid-phase collection medium, and then introduced into the GC-ICPMS system. Results: Limits of quantification were 0.4 and 0.03 g/L at a signal-to-noise ratio of 10 with the alkaline digestion and extraction methods, respectively. Extraction met our selected acceptable total error criterion, with an SD of 0.58 g/L at the critical maternal blood concentration of 5.8 g/L. Results obtained with alkaline digestion indicated the need for improved random analytical uncertainty, which was achieved by increasing the enrichment of the isotope dilution. For 37 blood samples, the mean (SD) proportion of total mercury present as methylmercury was 60 (27)%, range 6%-100%. Conclusions: The combination of extraction and isotope-dilution GC-ICPMS meets the requirements for use as a reference method for measuring methylmercury in whole blood.

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Determination of 60 elements in whole blood by sector field inductively coupled plasma mass spectrometry

Cited by 149 publications

References 31 publications

On chromium direct ETAAS determination in serum and urine

On chromium direct ETAAS determination in serum and urine

Determination of vanadium in biological fluids using HR-ICP-MS

Methylmercury Measurement in Whole Blood by Isotope-Dilution GC-ICPMS with 2 Sample Preparation Methods

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