Determination of ascorbic acid in pharmaceutical preparations by near infrared reflectance spectroscopy

Blanco, M.; Coello, J.; Iturriaga, H.; Maspoch, S.; Pezuela, C. de la

doi:10.1016/0039-9140(93)80083-4

Cited by 25 publications

(10 citation statements)

References 7 publications

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“…In the NIR region, characteristic bands of each component typically overlap with each other and generally hinder the identi® cation of individual components. NIR spectroscopy was used to determine vitamin C in pharmaceutical products at concentrations of 16.67, 22.88 and 40 % using step-wise multiple linear regression (SMLR) and partial least squares (PLS) regression (Blanco et al 1993) ; the prediction errors were 1± 2 % .…”

Section: Introductionmentioning

confidence: 99%

Rapid determination of vitamin C by NIR, MIR and FT-Raman techniques

Yang

Irudayaraj

2002

Journal of Pharmacy and Pharmacology

105

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Rapid spectroscopic determination of vitamin C in food and pharmaceutical products using infrared and Raman techniques was proposed. In this study, near-infrared (NIR), Fourier transform near-infrared (FT-NIR), Fourier transform infrared-attenuated total reflectance (FTIR-ATR), diffuse reflectance (DRIFTS), Fourier transform infrared-photoacoustic (FTIR-PAS) and FT-Raman spectroscopy were used in conjunction with partial least squares (PLS) regression to quantify vitamin C in powdered mixtures and solutions. Results indicate that the methods adopted have high prediction correlation. R2 values were 0.999 for FTIR-ATR, 0.976 for DRIFTS, 0.966 for FTIR-PAS, 0.988 for NIR, 0.992 for FT-NIR and 0.95 for FT-Raman, with an overall prediction error of 0.2-3.0%. The time required to complete an experiment ranged from 5 s (NIR) to 3 min (FT-Raman). The FTIR and FT-Raman techniques can be complementary tools for qualitative and quantitative characterization of the samples. Infrared and Raman techniques can be used to quantify vitamin C in foods and pharmaceutical products.

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Section: Introductionmentioning

confidence: 99%

Rapid determination of vitamin C by NIR, MIR and FT-Raman techniques

Yang

Irudayaraj

2002

Journal of Pharmacy and Pharmacology

105

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“…After separation, quantification must be performed using a gravimetric or detection tool such as ultraviolet (UV)-visible light (Pedersen and Kristensen 1999), the refractive index (Desbene et al 1996), an evaporative light scattering detector for HPLC (Zabaleta et al 2007), or spectroscopic techniques ( e.g., infrared (attenuated, transmittance, reflectance) or near infrared [NIR] spectrometry (Blanco et al 1996;Li and Worosila 2005;Blanco et al 1993)). Gravimetry is best suited for quantifying major excipients having significant weight ratios in the dosage unit.…”

Section: • Quantification Of the Identified Excipients In The Dosage mentioning

confidence: 99%

Role of Innovator Product Characterization in Generic Product Development

Munjal

Koradia

Boddu

et al. 2015

Excipient Applications in Formulation Design and Drug Delivery

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Generic drug products are defined as drug products that are comparable to the innovator/reference listed drug products (RLD) in dosage form, strength, route of administration, quality and performance characteristics, and intended use. These products play a critical role in the healthcare systems and contribute to more than 50 % of the total prescriptions by volume. Generic products are accorded regulatory approval based on the concept of therapeutic equivalence to the RLD. Therapeutic equivalence comprises of pharmaceutical equivalence and bioequivalence. Speed to the marketplace is the key for success in generic market. Development of generic products can be accelerated by performing characterization of the RLD, also referred as de-formulation studies. These studies, related to quantification of critical excipients, and solid state characterization of the active pharmaceutical ingredient, could provide critical inputs for formulation development of generic products. This chapter highlights the role of innovator product characterization in accelerating formulation development of generic products. Role of such studies in simplifying regulatory approval process has also been highlighted.

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“…This gives an opportunity to explore NIR spectra of vitamins and their relationships with the IR ones. NIR spectroscopy is often applied for determination of vitamin content in fruits and extracts [34,35], pharmaceutical formulations [36] or powdered mixtures and solutions [37]. However, these analytical applications of NIR spectroscopy do not rely on interpretation of the characteristic vibrational frequencies.…”

Section: Introductionmentioning

confidence: 99%

Anharmonicity and Spectra–Structure Correlations in MIR and NIR Spectra of Crystalline Menadione (Vitamin K3)

et al. 2021

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Mid-infrared (MIR) and near-infrared (NIR) spectra of crystalline menadione (vitamin K3) were measured and analyzed with aid of quantum chemical calculations. The calculations were carried out using the harmonic approach for the periodic model of crystal lattice and the anharmonic DVPT2 calculations applied for the single molecule model. The theoretical spectra accurately reconstructed the experimental ones permitting for reliable assignment of the MIR and NIR bands. For the first time, a detailed analysis of the NIR spectrum of a molecular system based on a naphthoquinone moiety was performed to elucidate the relationship between the chemical structure of menadione and the origin of the overtones and combination bands. In addition, the importance of these bands during interpretation of the MIR spectrum was demonstrated. The overtones and combination bands contribute to 46.4% of the total intensity of menadione in the range of 3600–2600 cm−1. Evidently, these bands play a key role in shaping of the C-H stretching region of MIR spectrum. We have shown also that the spectral regions without fundamentals may provide valuable structural information. For example, the theoretical calculations reliably reconstructed numerous overtones and combination bands in the 4000–3600 and 2800–1800 cm−1 ranges. These results, provide a comprehensive origin of the fundamentals, overtones and combination bands in the NIR and MIR spectra of menadione, and the relationship of these spectral features with the molecular structure.

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Determination of ascorbic acid in pharmaceutical preparations by near infrared reflectance spectroscopy

Cited by 25 publications

References 7 publications

Rapid determination of vitamin C by NIR, MIR and FT-Raman techniques

Rapid determination of vitamin C by NIR, MIR and FT-Raman techniques

Role of Innovator Product Characterization in Generic Product Development

Anharmonicity and Spectra–Structure Correlations in MIR and NIR Spectra of Crystalline Menadione (Vitamin K3)

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