Determination of B-complex vitamins in pharmaceutical formulations by surface-enhanced Raman spectroscopy

Alvarenga, Benedito Roberto de; Soares, Frederico Luis Felipe; Ardila, Jorge Armando; Durango, Luis Guillermo Cuadrado; Forim, Moacir Rossi; Carneiro, Renato Lajarim

doi:10.1016/j.saa.2017.07.049

Cited by 25 publications

(12 citation statements)

References 30 publications

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“…In addition, some of these methods are not portable, limiting their wider applicability for routine in situ field screening of consumable products. Raman and infrared spectroscopy are non-destructive and rapid techniques that require a small sample size and are capable of solid and liquid sample analysis with little or no sample preparation, making them ideal for fingerprinting, determination of authenticity, and quality assurance of consumable products including edible oils [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ]. Besides, Raman and infrared spectrometers are portable and fairly inexpensive, allowing affordable and fast in situ field screening of consumable products.…”

Section: Introductionmentioning

confidence: 99%

“…Research from our laboratory [ 51 , 52 ] and from other research laboratories [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ] has revealed the potential utility of the combined use of molecular spectroscopy and multivariate regression analysis for food purity analysis and quality assurance of adulterated edible oils and essential oils. However, numerous edible oils of high dietary importance and market values such as highly refined peanut oil (HRPO) that are susceptible to adulteration and/or trafficking are yet to be investigated.…”

Section: Introductionmentioning

confidence: 99%

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Detection, Purity Analysis, and Quality Assurance of Adulterated Peanut (Arachis hypogaea) Oils

Smithson

Fakayode

Henderson

et al. 2018

Foods

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The intake of adulterated and unhealthy oils and trans-fats in the human diet has had negative health repercussions, including cardiovascular disease, causing millions of deaths annually. Sadly, a significant percentage of all consumable products including edible oils are neither screened nor monitored for quality control for various reasons. The prospective intake of adulterated oils and the associated health impacts on consumers is a significant public health safety concern, necessitating the need for quality assurance checks of edible oils. This study reports a simple, fast, sensitive, accurate, and low-cost chemometric approach to the purity analysis of highly refined peanut oils (HRPO) that were adulterated either with vegetable oil (VO), canola oil (CO), or almond oil (AO) for food quality assurance purposes. The Fourier transform infrared spectra of the pure oils and adulterated HRPO samples were measured and subjected to a partial-least-square (PLS) regression analysis. The obtained PLS regression figures-of-merit were incredible, with remarkable linearity (R2 = 0.994191 or better). The results of the score plots of the PLS regressions illustrate pattern recognition of the adulterated HRPO samples. Importantly, the PLS regressions accurately determined percent compositions of adulterated HRPOs, with an overall root-mean-square-relative-percent-error of 5.53% and a limit-of-detection as low as 0.02% (wt/wt). The developed PLS regressions continued to predict the compositions of newly prepared adulterated HRPOs over a period of two months, with incredible accuracy without the need for re-calibration. The accuracy, sensitivity, and robustness of the protocol make it desirable and potentially adoptable by health departments and local enforcement agencies for fast screening and quality assurance of consumable products.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection, Purity Analysis, and Quality Assurance of Adulterated Peanut (Arachis hypogaea) Oils

Smithson

Fakayode

Henderson

et al. 2018

Foods

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“…They play an important role in biological redox or nonredox reactions as electron donors or acceptors by releasing or accepting a hydride . Nicotinamide (NA), a water‐soluble derivative of vitamin B 3 , is an important component of NADH and NADPH cofactors …”

Section: Introductionmentioning

confidence: 99%

A Computational Study on the Hydride Transfer Mechanism between Nicotinamide and Menadione

Rezazadeh

Ebrahimi

2018

ChemistrySelect

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Menadione (MD) or vitamin K3 is a component of multivitamin drugs, which exhibits a wide range of pharmacological effects relevant to human health. Nicotinamide adenine dinucleotide (NAD) catalyzes the oxidation process of MD through hydride transfer from nicotinamide (NA) to MD. In the present study, the hydride transfer mechanism between NA and MD was investigated using the quantum mechanical calculations at the M06-2X/6-31G (d,p) level of theory in the gas-phase and solution media. Two mechanisms were proposed to clarify the cyclic redox of MD via NA: one includes direct hydride transfer (DHT) in one step and other includes single electron and proton transfer (SET-PT) in two steps through an intermediate. Although the energy barrier is almost equal on two pathways, the results of natural bond orbital (NBO), and the molecular electrostatic potential (MEP) are clearly in agreement with the SET-PT mechanism, which is preferred to the DHT mechanism for hydride transfer from NA to MD. The cation and anion radicals of NA and MD facilitate the proton transfer from NA to MD in the SET-PT pathway. In addition, the binding energy between NA and MD and the energy barrier of proton transfer increase by the electron-withdrawing substituents (EWSs) and decrease by electron-donating substituents (EDSs) located at the C3 position of NA. A higher binding energy makes the intermediate more stable, which is accompanied with the increase in the energy barrier of proton transfer step.

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“…This also means that the orientation of ATZ molecules on AgNP is crucial for this ultrasensitive analysis. One may infer that signal enhancement for analytes can be obtained by tailoring the size and shape of the nanoparticles [12][13][14], in addition to the conformation of the analyte adsorbed as in the detection of B-complex vitamins in pharmaceutical samples [15].Such control in nanoparticle shape is afforded through various synthetic routes [16][17][18], then allowing the Localized Surface Plasmon Resonances (LSPR) to be tuned according to the region of best response (excitation) of the analyte [14,18,19]. For example, the near electromagnetic field is higher in nanoprisms (AgNPR), nanostars (AgNS) and nanorods (AgNR) than on spherical nanoparticles (AgNP) [18,19], and the LSPR may be wider to allow excitation down to the near infrared (IR) [18][19][20].…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Designing Silver Nanoparticles for Detecting Levodopa (3,4-Dihydroxyphenylalanine, L-Dopa) Using Surface-Enhanced Raman Scattering (SERS)

Rubira

Camacho

Martin

et al. 2019

Sensors

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Detection of the drug Levodopa (3,4-dihydroxyphenylalanine, L-Dopa) is essential for the medical treatment of several neural disorders, including Parkinson's disease. In this paper, we employed surface-enhanced Raman scattering (SERS) with three shapes of silver nanoparticles (nanostars, AgNS; nanospheres, AgNP; and nanoplates, AgNPL) to detect L-Dopa in the nanoparticle dispersions. The sensitivity of the L-Dopa SERS signal depended on both nanoparticle shape and L-Dopa concentration. The adsorption mechanisms of L-Dopa on the nanoparticles inferred from a detailed analysis of the Raman spectra allowed us to determine the chemical groups involved. For instance, at concentrations below/equivalent to the limit found in human plasma (between 10 −7 -10 −8 mol/L), L-Dopa adsorbs on AgNP through its ring, while at 10 −5 -10 −6 mol/L adsorption is driven by the amino group. At even higher concentrations, above 10 −4 mol/L, L-Dopa polymerization predominates. Therefore, our results show that adsorption depends on both the type of Ag nanoparticles (shape and chemical groups surrounding the Ag surface) and the L-Dopa concentration. The overall strategy based on SERS is a step forward to the design of nanostructures to detect analytes of clinical interest with high specificity and at varied concentration ranges.Sensors 2020, 20, 15 2 of 18 atrazine (ATZ) on Ag nanospheres (AgNP) made it possible to detect picomolar concentrations of ATZ using SERS, whose intensity was higher in solution than in a cast film [7]. This also means that the orientation of ATZ molecules on AgNP is crucial for this ultrasensitive analysis. One may infer that signal enhancement for analytes can be obtained by tailoring the size and shape of the nanoparticles [12][13][14], in addition to the conformation of the analyte adsorbed as in the detection of B-complex vitamins in pharmaceutical samples [15].Such control in nanoparticle shape is afforded through various synthetic routes [16][17][18], then allowing the Localized Surface Plasmon Resonances (LSPR) to be tuned according to the region of best response (excitation) of the analyte [14,18,19]. For example, the near electromagnetic field is higher in nanoprisms (AgNPR), nanostars (AgNS) and nanorods (AgNR) than on spherical nanoparticles (AgNP) [18,19], and the LSPR may be wider to allow excitation down to the near infrared (IR) [18][19][20]. Indeed, Rycenga et al. [21] reported higher SERS activity for three molecules adsorbed on Ag nanocubes (AgNC) than on AgNP due to the wider LSPR for AgNC. Izquierdo-Lorenzo et al. [18] found that AgNPR were more efficient than AgNP for detecting aminoglutethimide used in sport doping owing to field enhancement in the corners of AgNPR, forming interstitial junctions, which are called "hot spots".The adsorption (and orientation, as a consequence) of an analyte can in principle be controlled by: (a) the affinity between analyte and metal; (b) charge of the analyte, which can be modulated via pH; (c) size and shape of the nanoparticles, and (d) metallic surface, wh...

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Determination of B-complex vitamins in pharmaceutical formulations by surface-enhanced Raman spectroscopy

Cited by 25 publications

References 30 publications

Detection, Purity Analysis, and Quality Assurance of Adulterated Peanut (Arachis hypogaea) Oils

Detection, Purity Analysis, and Quality Assurance of Adulterated Peanut (Arachis hypogaea) Oils

A Computational Study on the Hydride Transfer Mechanism between Nicotinamide and Menadione

Designing Silver Nanoparticles for Detecting Levodopa (3,4-Dihydroxyphenylalanine, L-Dopa) Using Surface-Enhanced Raman Scattering (SERS)

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