Determination of complete sequence information of the human ABO blood group orthologous gene in pigs and breed difference in blood type frequencies

Choi, Mi Hyun; Lee, Wang Jae; Cho, Hyesun; Yum, Joori; Kang, Mingue; Song, Hyuk; Kim, Jin‐Hoi; Chung, Hwa‐Jin; Hong, Kwonho; Park, Chankyu

doi:10.1016/j.gene.2017.09.047

Cited by 12 publications

(25 citation statements)

References 26 publications

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“…A transferase expression in pig tissue is regulated by the genetic locus EAO on pig chromosome 6 corresponding to the orthologous site for the A transferase gene (OMIA 006089-9823) [23,24]. There are four genotypes for the “pig O histo-group system” coding for A histo group antigenicity: AA, AO, OO, and negative [24,[26], [27], [28]]. This locus coding is different from that for the A transferase gene coding for the A antigen expression on pig erythrocyte (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…The genetic determination of allele A frequency and genotype for the histo group was determined recently in a large series in commercial pigs of different strains as well as mini-pigs. In commercial pigs used for bioprotheses, the A allele frequency varies from 0.15 to 0.67 [57]. Currently, the bioprosthetic tissue phenotype is not checked during fabrication.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, the bioprosthetic tissue phenotype is not checked during fabrication. The A-allele frequency depends on the breed and varies from 0.15 to 0.67 [[26], [27], [28], [29],58] [57]. According to Oriol et al, [51%] of pigs are A+ and [12%] A + H+ [25].…”

Section: Discussionmentioning

confidence: 99%

“…locus EAO on pig chromosome 6) corresponding to the orthologous site for the A transferase gene (OMIA 006089-9823) [23,24] and controlling A antigen expression in the tissue. Unlike the α-Gal, which is expressed by all pigs in all their tissues, expression of the A-antigen is restricted to A-type pigs [[25], [26], [27], [28]]. The porcine A-antigen [27,29] [24,30] [31], is identical to the human A-antigen of the ABO blood group [32] and is synthesized by the same enzyme (A-transferase) [23].…”

Section: Introductionmentioning

confidence: 99%

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Recipients with blood group A associated with longer survival rates in cardiac valvular bioprostheses

Schussler¹,

Lila

Perneger³

et al. 2019

EBioMedicine

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Background Pigs/bovines share with humans some of the antigens present on cardiac valves. Two such antigens are: the major xenogenic Ag, “Gal” present in all pig/bovine very close to human B-antigen of ABO-blood-group system; the minor Ag, pig histo-blood-group AH-antigen identical to human AH-antigen and present by some animals. We hypothesize that these antigens may modify the immunogenicity of the bioprosthesis and also its longevity. ABO distribution may vary between patients with low (<6 years) and high (≥15 years) bioprostheses longevity. Methods Single-centre registry study (Paris, France) including all degenerative porcine bioprostheses (mostly Carpentier-Edwards 2nd/3rd generation heart valves) explanted between 1985 and 1998 and some bovine bioprostheses. For period 1998–2014, all porcine bioprostheses with longevity ≥13 years (follow-up ≥29 years). Important predictive factors for bioprosthesis longevity: number, site of implantation, age were collected. Blood group and other variables were entered into an ordinal logistic regression analysis model predicting valve longevity, categorized as low (<6 years), medium (6–14.9 years), and high (≥15 years). Findings Longevity and ABO-blood group were obtained for 483 explanted porcine bioprostheses. Mean longevity was 10.2 ± 3.9 years [0–28] and significantly higher for A-patients than others ( P = 0.009). Using multivariate analysis, group A was a strong predictive factor of longevity (OR 2.09; P < 0.001). For the 64 explanted bovine bioprosthesis with low/medium longevity, the association, with A-group was even more significant. Interpretation Patients of A-group but not B have a higher longevity of their bioprostheses. Future graft-host phenotyping and matching may give rise to a new generation of long-lasting bioprosthesis for implantation in humans, especially for the younger population. Fund None.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Recipients with blood group A associated with longer survival rates in cardiac valvular bioprostheses

Schussler¹,

Lila

Perneger³

et al. 2019

EBioMedicine

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“…Four non-synonymous ABO SNPs (R37G, A48P, S60R, G66C) segregated in the F6 and F7 generation but none of these were in high LD with any of the lead SNPs ( Kb deletion encompassing the last exon (eight) of the acetyl-galactosaminyl transferase gene has been previously reported in the pig. It causes a null allele equivalent to human "O", while the wild-type allele corresponds to the human "A" allele with alpha 1-3-N-acetylgalactosaminyl-transferase activity (Choi et al, 2018). The pig Sus scrofa 11.1 reference genome corresponds to the "O" allele.…”

Section: Generating a Large Mosaic Pig Population For Genetic Analysimentioning

confidence: 99%

An ancient deletion in the ABO gene affects the composition of the porcine microbiome by altering intestinal N-acetyl-galactosamine concentrations

Yang

Huang

et al. 2020

Preprint

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SummaryWe have generated a large heterogenous stock population by intercrossing eight divergent pig breeds for multiple generations. We have analyzed the composition of the intestinal microbiota at different ages and anatomical locations in > 1,000 6th- and 7th- generation animals. We show that, under conditions of exacerbated genetic yet controlled environmental variability, microbiota composition and abundance of specific taxa (including Christensenellaceae) are heritable in this monogastric omnivore. We fine-map a QTL with major effect on the abundance of Erysipelotrichaceae to chromosome 1q and show that it is caused by a common 2.3-Kb deletion inactivating the ABO acetyl-galactosaminyl-transferase gene. We show that this deletion is a trans-species polymorphism that is ≥3.5 million years old and under balancing selection. We demonstrate that it acts by decreasing the concentrations of N-acetyl-galactosamine in the cecum thereby reducing the abundance of Erysipelotrichaceae strains that have the capacity to import and catabolize N-acetyl-galactosamine.

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Erythrocyte Antigens and Blood Groups

Blais¹,

Penedo²

2022

Schalm's Veterinary Hematology

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Determination of complete sequence information of the human ABO blood group orthologous gene in pigs and breed difference in blood type frequencies

Cited by 12 publications

References 26 publications

Recipients with blood group A associated with longer survival rates in cardiac valvular bioprostheses

Recipients with blood group A associated with longer survival rates in cardiac valvular bioprostheses

An ancient deletion in the ABO gene affects the composition of the porcine microbiome by altering intestinal N-acetyl-galactosamine concentrations

Erythrocyte Antigens and Blood Groups

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