“Determination of domperidone in tablet dosage form by anodic differential pulse voltammetry”

Wahdan, Tarek; El-Ghany, Nadia Abd

doi:10.1016/j.farmac.2005.07.001

Cited by 29 publications

(14 citation statements)

References 7 publications

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“…Domperidone is a dopamine (D 2 ) antagonist prescribed for the treatment of nausea and vomiting of various etiologies (10). The typical dose of domperidone is 10-40 mg daily and is 91-93% protein bound having an elimination half-life of 5-7 h. Domperidone is a weak base having pH-dependent solubility (11).…”

Section: Introductionmentioning

confidence: 99%

Modulation of pH-Independent Release of a Class ΙΙ Drug (Domperidone) from a Polymeric Matrix Using Acidic Excipients

Khan¹,

Iqbal²,

Khan³

et al. 2016

Dissolution Technol.

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Drug release from polymeric matrix systems is the rate-limiting step for drug bioavailability and is determined by drug solubility; most drugs show pH-dependent solubility. Polymeric matrices remain in the gastrointestinal tract for a longer period of time and are exposed to environments of varying pH, which can adversely affect drug release. In the present study, the pH-independent drug release of domperidone was achieved by modifying the microenvironmental pH of a swollen polymeric matrix using acidic excipients (citric acid and tartaric acid). Matrices were prepared by a water-based, wet-granulation technique and evaluated for various official and unofficial parameters. In vitro drug release was studied using USP dissolution apparatus and pH 6.80 phosphate buffer as dissolution medium. Release kinetics was evaluated according to various mathematical models.Results show that domperidone release can be effectively modified by inclusion of acidic excipients in the formulations. Acidic excipients modulated microenvironmental pH and avoided the effect of dissolution medium pH on drug release. The resultant formulations are easy to prepare and scale up for commercial manufacturing. Better pH-independent release, following zero-order kinetics, was achieved with tartaric acid.

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Section: Introductionmentioning

confidence: 99%

Modulation of pH-Independent Release of a Class ΙΙ Drug (Domperidone) from a Polymeric Matrix Using Acidic Excipients

Khan¹,

Iqbal²,

Khan³

et al. 2016

Dissolution Technol.

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“…Of the non-chromatographic methods, the methods based on voltammetric [4,5] and potentiometric sensor [6] techniques involve rigid pH control. Compared with most of the existing methods for DOM, the present methods are very simple and cost effective.…”

Section: Discussionmentioning

confidence: 99%

“…Several methods have been reported for the determination of domperidone in pharmaceuticals, including differential pulse voltammetry [4], anodic difference pulse voltammetry [5], potentiometry [6], planar chromatography [7], high-performance liquid chromatography [8][9][10][11][12][13][14][15][16][17][18][19] and high-performance thin-layer chromatography [20][21][22][23][24][25]. Many of these techniques are deficient in simplicity, cost-effectiveness and easy accessibility.…”

mentioning

confidence: 99%

Of bromination reaction for the spectrophotometric assay of domperidone in pharmaceuticals

Devi¹,

Basavaiah²,

Vinay³

2011

CI&CEQ

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Three simple and sensitive spectrophotometric methods are described for the determination of domperidone (DOM) in bulk drug and in dosage forms using bromate-bromide mixture as brominating agent in acid medium and three dyes, meta-cresol purple (MCP), amaranth (AMR) and erioglaucine (EGC). The methods involve the addition of a known excess of bromate-bromide mixture to an acidified solution of DOM followed by the determination of the residual bromine by reacting with a fixed amount of either MCP dye and measuring the absorbance at 530 nm (method A) or AMR dye and measuring the absorbance at 520 nm (method B) or EGC dye and measuring the absorbance at 630 nm (method C). Beer's law is obeyed over the concentration ranges, 0.63-10.0, 0.25-4.0 and 0.13-2.0 µg mL -1 for method A, B and C, respectively. The apparent molar absorptivities are calculated to be 3.751×10 4 , 6.604×10 4 and 1.987×10 5 L mol -1 cm -1 for method A, B and C, respectively, and the corresponding sandell sensitivity values are 0.011, 0.006 and 0.002 μg cm -2 . The limit of detection and the limit of quantification are also reported for all the three methods. No interference was observed from common additives found in pharmaceutical preparations. Statistical comparisons of the results with those of the reference method showed excellent agreement, and indicated no significant difference in accuracy and precision. The accuracy and reliability of the methods were further ascertained by performing recovery tests via standard--addition technique.

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“…Planar chromatography, 4 high-performance liquid chromatography [5][6][7][8][9][10][11][12][13][14][15] and highperformance thin-layer chromatography [16][17][18][19][20] have been used to assay DOM. The drug has also been assayed by differential pulse voltammetry 21 and anodic difference pulse voltammetry 22 at a glassy carbon electrode in Britton-Robinson buffer. Application of potentiometric sensors 23 for the analysis of DOMcontaining tablets using PVC membrane and carbon paste sensors has also been reported.…”

Section: Standard Dom Solutionmentioning

confidence: 99%

Sensitive and Selective Extraction Free Ion-Pair Complexometric Determination of Domperidone in Pharmaceuticals and in Spiked Human Urine

Zenita

Basavaiah

Vinay

2011

J. Chil. Chem. Soc.

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Domperidone (DOM) is a drug used as an antiemetic and to control gastrointestinal effects of dopaminergic drugs in the management of perkinsonism. Two simple, rapid, sensitive and selective extraction free spectrophotometric methods have been developed for the assay of DOM in pure drug, in pharmaceuticals and in spiked human urine sample. The methods are based on the formation of yellow ion-pair complexes between DOM and two sulphonphthalein dyes viz., thymol blue (method A) and bromothymol blue (method B) in acetone and dichloromethane medium. The complexes showed absorption maxima at 390 nm and 410 nm in method A and method B, respectively. Reaction conditions were optimized to obtain the maximum color intensity. The absorbance was found to increase linearly with increase in concentration of DOM, which was corroborated by the calculated correlation values of 0. . The composition of the ion-pairs was found to be 1 : 1 by Job's method and the conditional stability constant (K f ) of the complexes have been calculated. The proposed methods were applied successfully to the determination of DOM in tablets as well as in spiked urine sample with good accuracy and precision.

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“Determination of domperidone in tablet dosage form by anodic differential pulse voltammetry”

Cited by 29 publications

References 7 publications

Modulation of pH-Independent Release of a Class ΙΙ Drug (Domperidone) from a Polymeric Matrix Using Acidic Excipients

Modulation of pH-Independent Release of a Class ΙΙ Drug (Domperidone) from a Polymeric Matrix Using Acidic Excipients

Of bromination reaction for the spectrophotometric assay of domperidone in pharmaceuticals

Sensitive and Selective Extraction Free Ion-Pair Complexometric Determination of Domperidone in Pharmaceuticals and in Spiked Human Urine

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