Determination of hydrazine by liquid chromatography with preliminary derivatization with naphthalene-2,3-dialdehyde

Smolenkov, A. D.; Chernobrovkina, A. V.; Smirnov, R. S.; Шпигун, О. А.

doi:10.1134/s1061934812040120

Cited by 22 publications

(10 citation statements)

References 9 publications

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“…In comparison to other methods, the LOD was similar to values obtained by GC-MS [27], GC-MS/MS [28] and LC-MS/MS [36] that required solid phase microextraction or liquid-liquid extraction and concentration, as described in Table 2. As observed, the LOD of the proposed method was approximately 15 times lower than those of the methods using HPLC after derivatization with NDA [34,35] even though the proposed method employed a very small sample and injection volume.…”

Section: Verification Of Methods Performancementioning

confidence: 60%

“…The NDA reaction conditions with hydrazine were very similar to the pH values [24,34,35], reaction temperatures and times [34,35] employed in previous studies. …”

Section: Optimization Of Derivatization Conditionsmentioning

confidence: 93%

“…In particular, the reaction with propyl chloroformate [28] results in three products (i.e., bi-, tri-, and tetra-derivatives), which make the quantification of hydrazine challenging. HPLC methods also require derivatization reagents, such as 4-chloro-5,7-dinitrobenzofurazan [20,31], cinnamaldehyde [29], benzaldehyde [30], and naphthalene-2,3-dialdehyde (NDA) [32][33][34][35]. The most sensitive HPLC method for the determination of hydrazine in water involves the fluorescent derivatization of hydrazine with NDA [32][33][34][35], which yields a hydrazine detection limit of 0.05 g/L.…”

Section: Introductionmentioning

confidence: 99%

“…GC methods for hydrazine have been developed using electron capture detection [21], nitrogen-selective detection [22,23], flame-ionization detection [24], mass spectrometry (MS) [23,[25][26][27], and tandem mass spectrometry (MS/MS) [19,28]. HPLC methods have also been developed using diode array detection [20,[29][30][31] and fluorescence detection [32][33][34][35]. Both the GC and LC methods require a derivatization step for the sensitive detection of hydrazine.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Simple and sensitive determination of hydrazine in drinking water by ultra-high-performance liquid chromatography–tandem mass spectrometry after derivatization with naphthalene-2,3-dialdehyde

Shin

2015

Journal of Chromatography A

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Section: Verification Of Methods Performancementioning

confidence: 60%

“…The NDA reaction conditions with hydrazine were very similar to the pH values [24,34,35], reaction temperatures and times [34,35] employed in previous studies. …”

Section: Optimization Of Derivatization Conditionsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Simple and sensitive determination of hydrazine in drinking water by ultra-high-performance liquid chromatography–tandem mass spectrometry after derivatization with naphthalene-2,3-dialdehyde

Shin

2015

Journal of Chromatography A

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“…The high importance of HZ in industrial, environmental and pharmaceutical fields have motivated the development of several analytical methodologies for HZ determination, such as spectrophotometry, 8 injection analysis based systems, 9 chromatographic methods, 10,11 and electrochemical methods. [12][13][14][15] The electrochemical methods present some interesting properties in comparison to the previously presented non-electrochemical methods, since they do not require long preparing steps, analytical grade reagents or skilled operators for the analysis.…”

Section: Introductionmentioning

confidence: 99%

Amperometric Electrochemical Platform for Hydrazine Determination Exploiting Reduced Graphene Oxide, Co(Salophen) and DNA: Application in Pharmaceutical Formulations Samples

Freitas¹,

Lima²,

Silva³

et al. 2018

J. Braz. Chem. Soc.

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The present work presents the development of a sensitive and selective amperometric sensor for the determination of hydrazine (HZ) in pharmaceutical formulations using a glassy carbon electrode (GCE) modified with a composite based on Co(Salophen), reduced graphene oxide (rGO) and deoxyribonucleic acid (DNA). The rGO/Co(Salophen)/DNA composite was characterized by using Fourier-transform infrared spectroscopy (FTIR), cyclic voltammetry, and amperometry. The proposed platform presented a well-defined voltammetric profile with a redox couple around 0.32 V vs. Ag/AgCl which showed excellent catalytic activity towards HZ oxidation. The peak current of HZ electrochemical oxidation on the proposed electrochemical platform have changed linearly with the HZ concentration in the range from 2 to 364 µmol L -1 . The proposed platform presented sensitivity, limit of detection, and limit of quantification of 0.056 µA L µmol , and 1.64 µmol L -1 to HZ, respectively. The relative standard deviation for eight determinations using a solution of 50 µmol L -1 HZ was 0.85%. The proposed sensor was successfully applied for the determination of HZ in pharmaceutical formulations, and the recovery tests showed a good accuracy with recovery percentage between 99 and 101%.Keywords: sensor, Co(Salophen), reduced graphene oxide, DNA, hydrazine, pharmaceutical formulations IntroductionNowadays, the interest on hydrazine (HZ) has been increasing due to its high reactivity, which has been exploited in the production of a number of materials including insecticides and pesticides, as well as it has been employed in the preparation of some pharmaceutical formulations such as nifuroxazide, carbidopa, hydralazine, dihydralazine, isoniazid and iproniazide. [1][2][3][4] On the other hand, the HZ is an extremely toxic compound as stated by some regulatory agencies such as the United States Environmental Protection Agency and the European Medicines Agency. 5,6 According to regulatory agencies, the recommended levels of HZ in medicinal products such as isoniazid based drugs is of 125 ppm 5,6 since the exposition to high levels of hydrazine can be harmful to human life because of its potential carcinogenic and mutagenic effects. [5][6][7] In this sense, the monitoring of HZ in pharmaceutical formulations is of high importance to ensure the quality of the medicines released for consumption by the population.The high importance of HZ in industrial, environmental and pharmaceutical fields have motivated the development of several analytical methodologies for HZ determination, such as spectrophotometry, 8 injection analysis based systems, 9 chromatographic methods, 10,11 and electrochemical methods. [12][13][14][15] The electrochemical methods present some interesting properties in comparison to the previously Freitas et al. 2097 Vol. 29, No. 10, 2018 presented non-electrochemical methods, since they do not require long preparing steps, analytical grade reagents or skilled operators for the analysis. In this sense, the electrochemical methods show excell...

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Sensitive determination of hydrazine in water by gas chromatography–mass spectrometry after derivatization with ortho-phthalaldehyde

Park

Shin

2013

Analytica Chimica Acta

110

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Determination of hydrazine by liquid chromatography with preliminary derivatization with naphthalene-2,3-dialdehyde

Cited by 22 publications

References 9 publications

Simple and sensitive determination of hydrazine in drinking water by ultra-high-performance liquid chromatography–tandem mass spectrometry after derivatization with naphthalene-2,3-dialdehyde

Simple and sensitive determination of hydrazine in drinking water by ultra-high-performance liquid chromatography–tandem mass spectrometry after derivatization with naphthalene-2,3-dialdehyde

Amperometric Electrochemical Platform for Hydrazine Determination Exploiting Reduced Graphene Oxide, Co(Salophen) and DNA: Application in Pharmaceutical Formulations Samples

Sensitive determination of hydrazine in water by gas chromatography–mass spectrometry after derivatization with ortho-phthalaldehyde

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