Determination of Isonicotinic Acid Hydrazide in Serum

Bartels, H. M.; Spring, Philipp

doi:10.1159/000221838

Cited by 4 publications

(1 citation statement)

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“…Almost all of the functions of CD147 that have been investigated to date have been associated with the membrane portion of CD147 [ 35 ]. We have previously reported that CD147 distributes to the cytoplasm in certain metastatic melanomas and have identified novel functions of CD147 in the endoplasmic reticulum (ER), including maintaining both calcium homeostasis and mitochondrial function [ 21 , 36 ]. This study identified the nuclear envelope distribution of CD147 in melanoma and highlights a novel mechanism of CD14 7 in controlling melanoma metastasis.…”

Section: Discussionmentioning

confidence: 99%

Nuclear envelope-distributed CD147 interacts with and inhibits the transcriptional function of RING1 and promotes melanoma cell motility

Chen

Peng

et al. 2017

PLoS ONE

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Melanoma accounts for nearly 80% of all deaths associated with skin cancer.CD147 plays a very important role in melanoma progression and the expression level may correlate with tumor malignancy. RING1 can bind DNA and act as a transcriptional repressor, play an important role in the aggressive phenotype in melanoma. The interactions between CD147 and RING1 were identified with a yeast two-hybrid and RING1 interacted with CD147 through the transmembrane domain. RING1 inhibits CD147’s capability promoting melanoma cell migration. In conclusion, the study identified novel interactions between CD147 and RING1, recovered CD147 nuclear envelope distribution in melanoma cells, and suggested a new mechanism underlying how cytoplasmic CD147 promotes melanoma development.

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Section: Discussionmentioning

confidence: 99%