Determination of Ki-67 expression in oral leukoplakia in snuff users and non-users in Khyber Pakhtunkhwa province of Pakistan.

Naushin, Tehmina; Khan, Muhammad Mumtaz; Ahmed, Sajjad; r., hassan m.; Fatima, Itrat; Bashir, Nasiha; Khan, Abbas Saleem

doi:10.29309/tpmj/2020.27.04.3124

Cited by 4 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oral leukoplakia is characterized by a whitish plaque in oral mucosa that cannot be removed by scraping, and it predisposes patients to oral cancer development [ 131 ]. It is closely related to the consumption of tobacco [ 132 ] and has also been associated with alcohol use [ 133 ], with fungal [ 134 ], bacterial [ 135 , 136 ], and viral [ 137 , 138 ] infections, and with hormonal disorders [ 139 , 140 ].…”

Section: Biomarkers In Saliva In Different Oral Diseasesmentioning

confidence: 99%

Salivary Biomarkers and Their Application in the Diagnosis and Monitoring of the Most Common Oral Pathologies

Melguizo‐Rodríguez

Costela‐Ruiz

Manzano-Moreno

et al. 2020

IJMS

View full text Add to dashboard Cite

Saliva is a highly versatile biological fluid that is easy to gather in a non-invasive manner—and the results of its analysis complement clinical and histopathological findings in the diagnosis of multiple diseases. The objective of this review was to offer an update on the contribution of salivary biomarkers to the diagnosis and prognosis of diseases of the oral cavity, including oral lichen planus, periodontitis, Sjögren’s syndrome, oral leukoplakia, peri-implantitis, and medication-related osteonecrosis of the jaw. Salivary biomarkers such as interleukins, growth factors, enzymes, and other biomolecules have proven useful in the diagnosis and follow-up of these diseases, facilitating the early evaluation of malignization risk and the monitoring of disease progression and response to treatment. However, further studies are required to identify new biomarkers and verify their reported role in the diagnosis and/or prognosis of oral diseases.

show abstract

Section: Biomarkers In Saliva In Different Oral Diseasesmentioning

confidence: 99%

Salivary Biomarkers and Their Application in the Diagnosis and Monitoring of the Most Common Oral Pathologies

Melguizo‐Rodríguez

Costela‐Ruiz

Manzano-Moreno

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…According to WHO oral leukoplakia (OL) is defined as a" white plaque of questionable risk having excluded other known disorders which carries an increased risk for cancer". 1 Approximately 80% of oral malignancies result from oral precursor lesions. 2 OL is considered one such disorder.…”

Section: Introductionmentioning

confidence: 99%

“…40% of SL tobacco users develop OL in comparison to 1.5% of non-tobacco users. 1 Oral snuff is a mixture of crushed tobacco, powdered lime, ash, indigo, cardamom oil, and menthol. [11][12][13] The present study is designed to assess histopathological features of Oral leukoplakia to report the probable relation of smokeless tobacco with the development of the said pathological entity in Pakistan research literature.…”

Section: Introductionmentioning

confidence: 99%

Histopathological Assessment of Oral Leukoplakia Among Snuff Users and Non-Users

Naushin

Khan

Ishfaq³

et al. 2023

JMS

View full text Add to dashboard Cite

Objectives: To assess histopathological characteristics of oral leukoplakia among snuff users and non-users. Material and methods: The descriptive cross-sectional study was conducted at different hospitals in Khyber Pakhtunkhwa. The study consisted of 60 cases of oral leukoplakia of which 30 were snuff users and 30 were non-users and histopathological features were assessed in both groups. SPSS 20 was used for the evaluation and analysis of the data. Results: The observed mean age of the cases was 50.3 years. In snuff users, the mean age was 56.97 (SD+14.71) while in non-users the mean age was 47.43 (SD+13.44). In snuff users, dysplasia 9/30 (30%) was the most common histopathological feature. The relationship between dysplasia in snuff users and non-users was found to be statistically significant with a p-value of 0.04. Conclusion: It is concluded from the present study that oral leukoplakia showed a wide range of histopathological features and these variants exist even among snuff users however the cases of dysplasia are high in snuff users than non-users which shows a greater potential for conversion of oral leukoplakia into malignancy in snuff users. Keywords: Oral leukoplakia, Dysplasia, Hyperplasia, Hyperkeratosis

show abstract

“…Nonhomogeneous leukoplakias have a variety of features; they can be exophytic, nodular, white or red in color, flat and speckled, or papillary/verrucous 2,5 . Patients with OL are prone to developing oral cancer (OC) 6 . OC is closely associated with smoking, alcohol consumption, fungal, bacterial, and viral infections, and hormonal disorders.…”

Section: Introductionmentioning

confidence: 99%

“… 2 , 5 Patients with OL are prone to developing oral cancer (OC). 6 OC is closely associated with smoking, alcohol consumption, fungal, bacterial, and viral infections, and hormonal disorders. OL is one of the most common oral potentially malignant disorders (OPTMs, defined as any oral mucosal abnormality that is associated with a statistically increased risk of developing OC.…”

Section: Introductionmentioning

confidence: 99%

Potential noninvasive biomarkers for the malignant transformation of oral leukoplakia: A systematic review and meta‐analysis

et al. 2023

View full text Add to dashboard Cite

Background:The rising cancer incidence in patients with oral leukoplakia (OL) highlights the importance of identifying potential biomarkers for high-risk individuals and lesions because these biomarkers are useful in developing personalized management strategies for OL patients.This study systematically searched and analyzed the literature on potential saliva and serum biomarkers for OL malignant transformation.Methods: PubMed and Scopus were searched for studies published up to April 2022. The primary outcome of this study was the difference in biomarker concentrations in saliva or serum samples from healthy control (HC), OL and oral cancer (OC) populations. Cohen's d with 95% credible interval was calculated and pooled using the inverse variance heterogeneity method.Results: A total of seven saliva biomarkers were analyzed in this paper, including interleukin-1alpha, interleukin-6 (IL-6), interleukin-6-8, tumor necrosis factor alpha (TNF-α), copper, zinc, and lactate dehydrogenase. IL-6 and TNF-α exhibited statistically significant deviations in comparisons between HC versus OL and OL versus OC. A total of 13 serum biomarkers were analyzed, including IL-6, TNF-α, C-reactive protein, total cholesterol, triglycerides, high-density lipoproteins, low-density lipoproteins, albumin, protein, β2-microglobulin, fucose, lipid-bound sialic acid (LSA), and total sialic acid (TSA). LSA and TSA exhibited statistically significant deviations in comparisons between HC versus OL and OL versus OC. Conclusion:IL-6 and TNF-α in saliva have strong predictive values for OL deterioration, and LSA and TSA concentration levels in serum also have the potential to serve as biomarkers for OL deterioration.

show abstract

Determination of Ki-67 expression in oral leukoplakia in snuff users and non-users in Khyber Pakhtunkhwa province of Pakistan.

Cited by 4 publications

References 17 publications

Salivary Biomarkers and Their Application in the Diagnosis and Monitoring of the Most Common Oral Pathologies

Salivary Biomarkers and Their Application in the Diagnosis and Monitoring of the Most Common Oral Pathologies

Histopathological Assessment of Oral Leukoplakia Among Snuff Users and Non-Users

Potential noninvasive biomarkers for the malignant transformation of oral leukoplakia: A systematic review and meta‐analysis

Contact Info

Product

Resources

About