Determination of log Poct values of chloro-substituted benzenes, toluenes and anilines by high-performance liquid chromatography on ODS-silica

Correlations Between n-Octanol/Water Partition Coefficients and RP-HPLC Capacity Factors of 1,2-Dithiole-3-thiones and 1,2-Dithiol-3-ones

“…9 In the perspective of a constructionist approach ,14,15 taking into account corrective factors for chain length, cycle effect, and steric hindrance to improve the fit between the predicted and experimental log P oct values, it became necessary to determine the log P oct of more lipophilic derivatives which are the most deviant. However, at this point we were faced with the problem that the conventional X Abstract published in Advance ACS Abstracts, August 1, 1996. shake-flask technique is not usable when log P oct is greater than 3.8-4.5 [16][17][18][19][20][21] according to the response of the solute to the analytical method used. It is well established that chromatography may provide quantitative information on the hydrophobicity of solute molecules.…”

Absorption and retention of polydimethylsiloxanes (silicones) in fish: Preliminary experiments†

“…Hydrophobicity determinations The apparent hydrophobicity of PDMS oligomers was measured by corrected retention times (i c = i r -I o ) in reversed-phase high performance liquid chromatography (RP-HPLC) on an octadecylsilica (C 18 ) column with methanol/water (90:10) as eluent. 11 ' 12 Apparent logP values were determined from retention indices using a homologous series of n-alkylbenzenes as reference compounds (see Ref. 13).…”

Solution equilibria of copper(II) complexation with N,N′-(2,2′-azanediylbis(ethane-2,1-diyl))dipicolinamide: A bio-distribution and dermal absorption study

“…1-Octanol and water are widely accepted as the best twophase system to model the partitioning between biomass and water. Despite the problems of emulsion formation associated with highly lipophilic substances [35] when the traditional shake-flask technique (SF) is used, this was the method of choice ahead of the stir-flask method (SS) [36] because the SS method would require long equilibration times of between 2 and 5 days.…”