Determination of morphine and codeine in urine using poly(dimethylsiloxane) microchip electrophoresis with electrochemical detection

Zhang, Qianli; Xu, Jing‐Juan; Li, Xiangyun; Lian, Hong-zhen; Chen, Hong‐Yuan

doi:10.1016/j.jpba.2006.06.003

Cited by 37 publications

(10 citation statements)

References 33 publications

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“…The calculated value of n = 2 for the electrocatalytic oxidation of MO is in agreement with the values reported in the literature [20,28,30,[51][52][53][54]. Also, the electrocatalytic oxidation mechanism of MO was investigated by plotting the scan rate normalized current (I p v À1/2 ) versus the scan rate (inset A of Fig.…”

Section: Resultssupporting

confidence: 88%

Electrocatalytic determination of morphine at the surface of a carbon paste electrode spiked with a hydroquinone derivative and carbon nanotubes

Shishehbore

Zare

Nematollahi

2012

Journal of Electroanalytical Chemistry

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Section: Resultssupporting

confidence: 88%

Electrocatalytic determination of morphine at the surface of a carbon paste electrode spiked with a hydroquinone derivative and carbon nanotubes

Shishehbore

Zare

Nematollahi

2012

Journal of Electroanalytical Chemistry

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“…Such inadvertent effects may include excessive nervous system stimulus, hindered breathing due to relaxed bronchial muscle, and the secretion of gastric acid, in addition to several other toxic and dangerous symptoms. [167][168][169][170][171][172] On top of these physical and biological side effects, social issues may develop due to the drug abuse and overuse, increasing the demand for facile drug testing. This need may be addressed using paper-based devices in the coming years.…”

Section: Drug Testingmentioning

confidence: 99%

Paper-based assays for urine analysis

et al. 2017

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A transformation of the healthcare industry is necessary and imminent: hospital-centered, reactive care will soon give way to proactive, person-centered care which focuses on individuals' well-being. However, this transition will only be made possible through scientific innovation. Next-generation technologies will be the key to developing affordable and accessible care, while also lowering the costs of healthcare. A promising solution to this challenge is low-cost continuous health monitoring; this approach allows for effective screening, analysis, and diagnosis and facilitates proactive medical intervention. Urine has great promise for being a key resource for health monitoring; unlike blood, it can be collected effortlessly on a daily basis without pain or the need for special equipment. Unfortunately, the commercial rapid urine analysis tests that exist today can only go so far-this is where the promise of microfluidic devices lies. Microfluidic devices have a proven record of being effective analytical devices, capable of controlling the flow of fluid samples, containing reaction and detection zones, and displaying results, all within a compact footprint. Moving past traditional glass- and polymer-based microfluidics, paper-based microfluidic devices possess the same diagnostic ability, with the added benefits of facile manufacturing, low-cost implementation, and disposability. Hence, we review the recent progress in the application of paper-based microfluidics to urine analysis as a solution to providing continuous health monitoring for proactive care. First, we present important considerations for point-of-care diagnostic devices. We then discuss what urine is and how paper functions as the substrate for urine analysis. Next, we cover the current commercial rapid tests that exist and thereby demonstrate where paper-based microfluidic urine analysis devices may fit into the commercial market in the future. Afterward, we discuss various fabrication techniques that have been recently developed for paper-based microfluidic devices. Transitioning from fabrication to implementation, we present some of the clinically implemented urine assays and their importance in healthcare and clinical diagnosis, with a focus on paper-based microfluidic assays. We then conclude by providing an overview of select biomarker research tailored towards urine diagnostics. This review will demonstrate the applicability of paper-based assays for urine analysis and where they may fit into the commercial healthcare market.

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“…Results obtained measuring these two analytes in rat serum and urine were determined to be consistent with that measured by high performance liquid chromatography (HPLC). In a separate work, this group also used a similar microfluidic system to quantify morphine and codeine in human urine samples [31]. In a report from Chen et al , a poly(methylmethacrylate) (PMMA) microchip having gold nanoelectrode ensemble (GNEE) working and decoupling electrodes for ECD was used for determination of mercaptopurine (MP), an important drug for inflammatory bowel disease and acute lymphoblastic leukemia treatment [32].…”

Section: Microseparationsmentioning

confidence: 99%

Review: Microfluidic applications in metabolomics and metabolic profiling

Kraly

Holcomb

Guan

et al. 2009

Analytica Chimica Acta

120

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Metabolomics is an emerging area of research focused on measuring small molecules in biological samples. There are a number of different types of metabolomics, ranging from global profiling of all metabolites in a single sample to measurement of a selected group of analytes. Microfluidics and related technologies have been used in this research area with good success. The aim of this review article is to summarize the use of microfluidics in metabolomics. Direct application of microfluidics to the determination of small molecules is covered first. Next, important sample preparation methods developed for microfluidics and applicable to metabolomics are covered. Finally, a summary of metabolomic work as it relates to analysis of cellular events using microfluidics is covered. KeywordsMicrofluidics; metabolomics; metabolic profiling; review I INTRODUCTIONThe goal of this review is to summarize the use of microfluidics as a novel tool set for metabolomics, metabolic profiling, and other metabolite related biological studies. To the knowledge of the authors this is the first such review generated, and thus we will include articles dating back as far as 2000 to give the reader a comprehensive view of the state of the art. While this is the first review of this topic, a number of important reviews on topics ranging from microfluidic and general analytical methods applicable to metabolomics [1][2][3][4][5][6] to metabolomic and metabolic profiling [7][8][9][10][11][12] have been published previously. For specific topics, it is suggested the reader consult these works. These reviews are by no means a comprehensive list of all reviews in this field given that several dozen review articles have been published over the last nine years ranging in scope from very specific to more general.Before discussing specific applications of microfluidics to metabolomics we will first define metabolomics and the various subsets of this discipline. While many people are familiar with genomics and proteomics, the terminology associated with metabolomics is not as clearly defined. For the sake of this review, we define metabolomics as five separate categories: 1) metabolomics, 2) metabonomics, 3) metabolic fingerprinting, 4) metabolic profiling, and 5) targeted metabolic profiling [13]. Metabolomics is the overall study of metabolite expression Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptAnal Chim Acta. Author manuscript; available in PMC 2010 October 19. Published in final edited form as:Anal Chim Acta. NIH-PA Author ManuscriptNIH-PA Author Manuscript ...

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Determination of morphine and codeine in urine using poly(dimethylsiloxane) microchip electrophoresis with electrochemical detection

Cited by 37 publications

References 33 publications

Electrocatalytic determination of morphine at the surface of a carbon paste electrode spiked with a hydroquinone derivative and carbon nanotubes

Electrocatalytic determination of morphine at the surface of a carbon paste electrode spiked with a hydroquinone derivative and carbon nanotubes

Paper-based assays for urine analysis

Review: Microfluidic applications in metabolomics and metabolic profiling

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