Determination of morphine at gold nanoparticles/Nafion® carbon paste modified sensor electrode

Atta, Nada F.; Galal, Ahmed M.; Azab, Shereen M.

doi:10.1039/c1an15423k

Cited by 67 publications

(27 citation statements)

References 61 publications

(76 reference statements)

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“…Risperidone and olanzapine are both electroactive, but their quantification at bare electrodes, as for most of the organic molecules with similar structure, has a number of limitations, such as slow electron transfer reaction, electrode fouling problems [4] and, often, reduced linearity between concentration and current intensity [5].…”

Section: Introductionmentioning

confidence: 99%

Electrochemistry of olanzapine and risperidone at carbon nanotubes modified gold electrode through classical and DFT approaches

Merli

Dondi

Pesavento

et al. 2012

Journal of Electroanalytical Chemistry

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Section: Introductionmentioning

confidence: 99%

Electrochemistry of olanzapine and risperidone at carbon nanotubes modified gold electrode through classical and DFT approaches

Merli

Dondi

Pesavento

et al. 2012

Journal of Electroanalytical Chemistry

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“…While the analysis of pharmaceuticals has historically been carried out by spectrophotometry, fluorometry and liquid or gas chromatographic methods [ 2 ], recent investigations have focused on electrochemical methods [ 3 – 5 ], especially for neurological drug analytes [ 6 , 7 ]. Electrochemical methods enable several unique advantages [ 8 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters

et al. 2014

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Nanomaterial-modified detection systems represent a chief driver towards the adoption of electrochemical methods, since nanomaterials enable functional tunability, ability to self-assemble, and novel electrical, optical and catalytic properties that emerge at this scale. This results in tremendous gains in terms of sensitivity, selectivity and versatility. We review the electrochemical methods and mechanisms that may be applied to the detection of neurological drugs. We focus on understanding how specific nano-sized modifiers may be applied to influence the electron transfer event to result in gains in sensitivity, selectivity and versatility of the detection system. This critical review is structured on the basis of the Anatomical Therapeutic Chemical (ATC) Classification System, specifically ATC Code N (neurotransmitters). Specific sections are dedicated to the widely used electrodes based on the carbon materials, supporting electrolytes, and on electrochemical detection paradigms for neurological drugs and neurotransmitters within the groups referred to as ATC codes N01 to N07. We finally discuss emerging trends and future challenges such as the development of strategies for simultaneous detection of multiple targets with high spatial and temporal resolutions, the integration of microfluidic strategies for selective and localized analyte pre-concentration, the real-time monitoring of neurotransmitter secretions from active cell cultures under electro- and chemotactic cues, aptamer-based biosensors, and the miniaturization of the sensing system for detection in small sample volumes and for enabling cost savings due to manufacturing scale-up. The Electronic Supporting Material (ESM) includes review articles dealing with the review topic in last 40 years, as well as key properties of the analytes, viz., pKa values, half-life of drugs and their electrochemical mechanisms. The ESM also defines analytical figures of merit of the drugs and neurotransmitters. The article contains 198 references in the main manuscript and 207 references in the Electronic Supporting Material.FigureᅟElectronic supplementary materialThe online version of this article (doi:10.1007/s00604-014-1308-4) contains supplementary material, which is available to authorized users.

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“…Application of electrochemical methods proved to be highly sensitive and selective techniques [10][11][12] for the detection of biological materials [13,14]. Many complications face the use of the electrochemical methods such as the influence of many analytes interferences, which may be present at higher concentrations.…”

Section: Introductionmentioning

confidence: 99%

Selective Electrochemical Detection of Epinephrine Using Gold Nanoporous Film

Fouad

El‐Said

2016

Journal of Nanomaterials

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Epinephrine (EP) is one of the important catecholamine neurotransmitters that play an important role in the mammalian central nervous system. Therefore, it is necessary to determine the change of its concentrations. Nanoporous materials have wide applications that include catalysis, energy storages, environmental pollution control, wastewater treatment, and sensing applications. These unique properties could be attributable to their high surface area, a large pore volume, and uniform pore sizes. A gold nanoporous layer modified gold electrode was prepared and applied for the selective determination of epinephrine neurotransmitter at low concentration in the presence of several other substances including ascorbic acid (AA) and uric acid (UA). The constructed electrode was characterized using scanning electron microscopy and cyclic voltammetry. The resulting electrode showed a selective detection of epinephrine with the interferences of dopamine and uric acid over a wide linear range (from 50 μM to 1 mM). The coverage of gold nanoporous on the surface of gold electrode represents a promising electrochemical sensor with high selectivity and sensitivity.

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Determination of morphine at gold nanoparticles/Nafion® carbon paste modified sensor electrode

Cited by 67 publications

References 61 publications

Electrochemistry of olanzapine and risperidone at carbon nanotubes modified gold electrode through classical and DFT approaches

Electrochemistry of olanzapine and risperidone at carbon nanotubes modified gold electrode through classical and DFT approaches

Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters

Selective Electrochemical Detection of Epinephrine Using Gold Nanoporous Film

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