Determination of naproxen with solid substrate room temperature phosphorimetry based on an orthogonal array design

Zhu, Guofeng; Ju, Huangxian

doi:10.1016/j.aca.2003.11.035

Cited by 58 publications

(28 citation statements)

References 21 publications

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“…Single-factor experiment and orthogonal array design (OAD) were used to optimize the experiment conditions. OAD is a kind of statistical based methods, in which orthogonal array is used to assign factors to a series of experimental combinations, whose results can then be treated by range analysis or analysis of variance (ANOVA) (Zhu et al, 2004;Bahramifar et al, 2005;Gu et al, 1998). The use of OAD can simplify the experimental procedure without affecting the quality of the results .…”

Section: Determination Of Concentration Of Flavonoidsmentioning

confidence: 99%

Study on Ultrasonic Extraction Technology and Oxidation Resistance of Total Flavonoids from Peanut Hull

Yang

Sun

et al. 2011

FSTR

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Section: Determination Of Concentration Of Flavonoidsmentioning

confidence: 99%

Study on Ultrasonic Extraction Technology and Oxidation Resistance of Total Flavonoids from Peanut Hull

Yang

Sun

et al. 2011

FSTR

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“…Several analytical methods have been reported for the determination of naproxen in pharmaceutical preparations including UV-visible spectrophotomery, [3][4][5] spectrofluorimetry, [6][7][8] room temperature phosphorimetry, 9,10 voltametry, 11 high-performance liquid chromatography, [12][13][14] capillary electrophoresis, 15,16 coulometry 17 and oscilometric titration. 18 However, most of these techniques are timeconsuming, involving the use of organic solvents or require expensive and sophisticated instruments and for this reason they are not suitable for routine analysis.…”

Section: Introductionmentioning

confidence: 99%

A novel potentiometric naproxenate ion sensor immobilized in a graphite matrix for determination of naproxen in pharmaceuticals

Santini¹,

Oliveira²,

Pezza³

et al. 2006

J. Braz. Chem. Soc.

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As características, o desempenho e a aplicação de um eletrodo do tipo Pt⎪Hg⎪Hg 2 (NAP) 2 ⎪ Graphite, onde NAP=íon naproxenato, são descritas. O eletrodo responde a NAP com sensibilidade de (58,1± 0,9) mV década -1 no intervalo de 5,0 × 10 -5 -1,0 × 10 -2 mol L -1 , a pH 6,0-9,0 e com um limite de detecção de 3,9 × 10 -5 mol L -1 . O eletrodo é de baixo custo e facilmente construído, apresenta um rápido tempo de resposta (10-35 s) e pode ser usado por um período de seis meses sem qualquer divergência considerável nos potenciais. O sensor supracitado mostrou boa seletividade para naproxeno na presença de várias substâncias, tais como carboxilatos e ânions inorgânicos, sendo aplicado na análise direta de naproxeno em medicamentos (comprimidos) via método da adição de padrão. Os resultados analíticos obtidos com o eletrodo proposto estão em boa concordância com aqueles obtidos pelo procedimento preconizado na Farmacopéia Americana.The characteristics, performance, and application of an electrode, namely, Pt⎪Hg⎪Hg 2 (NAP) 2 ⎪ Graphite, where NAP stands for naproxenate ion, are described. This electrode responds to NAP with sensivity of (58.1± 0.9) mV decade -1 over the range 5.0 × 10 -5 -1.0 × 10 -2 mol L -1 at pH 6.0-9.0 and a detection limit of 3.9 × 10 -5 mol L -1 . The electrode is easily constructed at a relatively low cost with fast response time (within 10-35 s) and can be used for a period of 6 months without any considerable divergence in potentials. The proposed sensor displayed good selectivity for naproxen in the presence of several substances, especially concerning carboxylate and inorganic anions. It was used for the direct assay of naproxen in commercial tablets by means of the standard additions method. The analytical results obtained by using this electrode are in good agreement with those given by the United States Pharmacopeia procedure.Keywords: naproxenate-sensitive electrode, potentiometry, pharmaceutical formulations Introduction Naproxen [(+)-2-(6-metoxy-2naphthyl)propionic acid], is a non-steroidal anti-inflammatory drug that also presents analgesic and antipyretic properties often preferred to acetylsalicylic acid because of its better absortion following oral administration and fewer adverse effects.Naproxen is extensively used in the treatment of many diseases like rheumatoid arthrits, degenerative joint disease, ankylosing spondylits, acute gout and primary dismenorrea. 1 Like other non-steroidal anti-inflammatory drugs, it inhibits the biosyntesis of prostaglandins. 1 The United States Pharmacopeia 2 2003 reports an highperformance liquid chromatography (HPLC) method for the determination of naproxen tablets. Several analytical methods have been reported for the determination of naproxen in pharmaceutical preparations including UV-visible spectrophotomery, 3-5 spectrofluorimetry, 6-8 room temperature phosphorimetry, 9,10 voltametry, 11 high-performance liquid chromatography, 12-14 capillary electrophoresis, 15,16 coulometry 17 and oscilometric titration. 18 However, most of these techniq...

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“…In order to optimize the extraction conditions, orthogonal array experimental design was employed. The theory and methodology of orthogonal array experimental design as a statistical method for the optimization of analytical procedures has been described in detail previously (Lan et al, 1995;Bagheri et al, 2000;Zhu and Ju, 2004). In this study, the eff ect of three factors on the recoveries was studied and optimized by an L 9 (3 4 ) orthogonal array.…”

Section: Optimization Of Microwave-assisted Extractionmentioning

confidence: 99%

Simultaneous determination of organophosphorus pesticides in Chinese herbal medicines by microwave‐assisted extraction coupled with dispersive‐solid phase extraction and gas chromatography

Wan

Mao

Yan

et al. 2010

Biomedical Chromatography

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A reliable, rapid and nontoxic analytical method was proposed for the simultaneous determination of 16 organophosphorus pesticides in Chinese herbal medicines. The pesticides were extracted by ethanol and the experimental variables, such as temperature, extraction time and volume of ethanol, were optimized through orthogonal array experimental design. Cleanup of extracts was performed with dispersive-solid phase extraction using primary secondary amine as the sorbent. The determination of pesticides in the final extracts was carried out by gas chromatography-flame photometric detection. Under optimized conditions the obtained recoveries, except for isocarbophos, were in the range 73.8-123%, with relative standard deviations equal to or lower than 15.2% and limits of detection ranging from 0.001 to 0.009 mg/kg.

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Determination of naproxen with solid substrate room temperature phosphorimetry based on an orthogonal array design

Cited by 58 publications

References 21 publications

Study on Ultrasonic Extraction Technology and Oxidation Resistance of Total Flavonoids from Peanut Hull

Study on Ultrasonic Extraction Technology and Oxidation Resistance of Total Flavonoids from Peanut Hull

A novel potentiometric naproxenate ion sensor immobilized in a graphite matrix for determination of naproxen in pharmaceuticals

Simultaneous determination of organophosphorus pesticides in Chinese herbal medicines by microwave‐assisted extraction coupled with dispersive‐solid phase extraction and gas chromatography

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