Determination of organochlorines, polychlorinated biphenyls and polybrominated diphenyl ethers in human hair: Estimation of external and internal exposure

Lu, Dasheng; Feng, Chao; Lin, Yuanjie; Wang, Dongli; Ip, Ho Sai Simon; Qiu, Xinlei; Wang, Guoquan; She, Jianwen

doi:10.1016/j.chemosphere.2014.04.109

Cited by 23 publications

(15 citation statements)

References 46 publications

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“…This is in line with the fact that the DDT impurity Fig. 1 Predicted charts for daily intake of ∑DDT (a) and ∑OCPs (c) of female neonates through breast milk consumption and sensitivity charts (b ∑DDT, d ∑OCPs) of all defined assumption generated against the daily intake of ∑DDT and ∑OCP forecast in dicofol formula in the Chinese market contributed to high exposure of Chinese population (Lu et al 2014;Qiu et al 2005). However, although the EDI values and even the predicted high-end daily intake values (the 99th percentile) were low, infants as the vulnerable subgroup are exposed to relatively higher doses of OCPs through consumption of more food per kilogram of body weight than adults are, and infants are more susceptible owing to their dynamic growth and developmental processes (Bennett et al 1996).…”

Section: Association Of Ocps With Consumption Of Animal-origin Foodsupporting

confidence: 69%

Organochlorine pesticides and their metabolites in human breast milk from Shanghai, China

Wang

et al. 2015

Environ Sci Pollut Res

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Organochlorine pesticides (OCPs) are persistent organic pollutants that could cause deleterious effects on human health. Breast milk represents a noninvasive specimen source to assess maternal and infant exposure to OCPs. This study recruited 142 pregnant mothers in 2011-2012 in Shanghai, China, and their breast milk samples were collected during lactation and analyzed for 27 OCP compounds. Detection rates were in a range of 65.5 to 100 %. In particular, metabolites of 2,2-bis(chlorophenyl)-1,1,1-trichloroethane (DDT) such as 2-chloro-1,1-bis(4-chlorophenyl)ethylene (DDMU), 2,2-bis(4-chlorophenyl)ethanol (DDOH), bis(4-chlorophenyl)ketone (DBP), and 4,4'-dichlorodiphenylmethane (DDM) were detected in most milk samples. DDTs, hexachlorobenzene (HCB), and hexachlorocyclohexane (HCH) were dominant OCPs with mean levels of 316, 49.8, and 41.5 ng/g lipid content, respectively, whereas levels of methoxychlor, ∑Drins, ∑Heptachlor, ∑Chlordane, and ∑Endosulfan were fairly low (0.87-5.6 ng/g lipid content). Milk concentrations of OCPs were weakly correlated with maternal age, body weight, and body mass indexes (BMIs). ∑OCPs in this study were much lower than those in human breast milk samples collected in 2002 and 2007. Consumption of higher amounts of fish was associated with higher milk levels of OCPs. Specific OCP patterns in breast milk samples from migrant mothers in Shanghai reflected features of OCP production, use, and exposure in their home provinces. The probabilistic exposure assessment model reveals that Shanghai infants were exposed to low levels of OCPs through breast milk consumption. However, infants as the vulnerable group might be subject to the potential additive and/or synergistic health effects from complex OCP exposure.

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Section: Association Of Ocps With Consumption Of Animal-origin Foodsupporting

confidence: 69%

Organochlorine pesticides and their metabolites in human breast milk from Shanghai, China

Wang

et al. 2015

Environ Sci Pollut Res

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“…Strands of the hair can incorporate PBDEs from the bloodstream (endogenous contamination) and adsorb them from the environment (exogenous contamination) . Many factors, such as age, sex, and hair color, can affect the incorporation of PBDEs into the hair .…”

Section: Resultsmentioning

confidence: 99%

“…The main advantages of using hair samples are the possibilities of short and long term monitoring, and the stability of a matrix with low or null active metabolic activities. Thus, once the PBDEs are incorporated into the keratinous tissue of the hair, their concentration remains relatively unchanged . Additionally, the preservation of human hair samples is more straightforward than that of conventional biological samples given that they can be effectively stored, in dark, dry conditions at room temperature…”

Section: Introductionmentioning

confidence: 99%

Enzymatic Digestion Coupled to Surfactant‐Assisted Dispersive Liquid‐Liquid Microextraction: A Mild Approach for Determining Polybrominated Diphenyl Ethers in Human Hair Sample

et al. 2020

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Enzymatic digestion, coupled to surfactant assisted‐dispersive liquid‐liquid microextraction (ED‐SA‐DLLME), is proposed as a mild innovative sample preparation methodology to determine polybrominated diphenyl ethers (PBDEs) in human hair samples by gas chromatography. The sodium dodecyl sulfate as a promoting agent in the ED stage also acts as a dispersive agent in DLLME, providing an advantageous synergy between sample preparation stages. Experimental variables of the ED‐SA‐DLLME were optimized using a multivariate method. The optimal experimental conditions were: proteinase K 0.96 U mL−1, SDS 1% (w/v), 37 °C, and 60 min for ED; and 50 μL tetrachloroethylene for SA‐DLLME. The notable analytical figures of merit showed LOQ in the range of 30–430 pg g−1, relative standard deviations <9%, and recoveries of 90–94%. The PBDEs were found in human hair samples <0.07 ng g−1.

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“…However, it is clear that new alternative analytical procedures for the analysis of the adipose are very much desired [26][27][28][29][30][31][32]. Although the development of obesity is easily attributed to an excess intake of calories, the underlying reasons for the metabolic disturbances and health risks associated with obesity are still unclear.…”

Section: Introductionmentioning

confidence: 99%

SEM (EDX) is an indispensable tool for the characterization of subcutaneous, preperitoneal and visceral adipose tissue of obese patients

Skaudžius¹,

Misevicius²,

Brimienė³

et al. 2018

chemija

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In this work the scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) elemental analysis were used for the characterization of adipose tissue samples taken from volunteer obese patients. The adipose tissue was taken from subcutaneous, preperitoneal and visceral layers of the adipose tissue. The obtained results provided information about the structural composition of adipose tissue layers in the human body, as well as the main microstructural features. It was demonstrated for the first time, to the best of our knowledge, that SEM and EDX are indispensable tools in order to investigate some special morphological features and the elemental composition of different layers of the human adipose tissue, identifying the surface microstructure and its qualitative composition. From the obtained results we concluded that such characterization of the adipose tissue is an essential step for the possible prediction of symptoms of different diseases.

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Determination of organochlorines, polychlorinated biphenyls and polybrominated diphenyl ethers in human hair: Estimation of external and internal exposure

Cited by 23 publications

References 46 publications

Organochlorine pesticides and their metabolites in human breast milk from Shanghai, China

Organochlorine pesticides and their metabolites in human breast milk from Shanghai, China

Enzymatic Digestion Coupled to Surfactant‐Assisted Dispersive Liquid‐Liquid Microextraction: A Mild Approach for Determining Polybrominated Diphenyl Ethers in Human Hair Sample

SEM (EDX) is an indispensable tool for the characterization of subcutaneous, preperitoneal and visceral adipose tissue of obese patients

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