Determination of Oxidative Stress Status and Concentration of TGF‐β1 in the Blood and Saliva of Osteoporotic Subjects

Yousefzadeh, Gholamreza; Larijani, Bagher; Mohammadirad, Azadeh; Heshmat, Ramin; Dehghan, Gholamreza; Rahimi, Roja; Abdollahi, Mohammad

doi:10.1196/annals.1378.062

Cited by 48 publications

(30 citation statements)

References 39 publications

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“…Indeed, oxidative stress alters bone remodeling process causing an unbalance between osteoclast and osteoblast activity, this can lead to metabolic bone diseases and contribute to the pathogenesis of skeletal system disorders including osteoporosis characterized by low bone mineral density and decrease in bone mass, which makes the bone weak and more prone to fracture (18,(33)(34)(35)(36). Recent evidences in a limited number of clinical studies have shown that ROS and/or antioxidant systems can be involved in the pathogenesis of bone loss (36)(37)(38)(39). In fact, oxidative stress activates the differentiation of preosteoclasts in osteoclasts and strengthens the bone resorption (18,40) (Figure 1).…”

Section: Oxidative Stress In Bone Remodelingmentioning

confidence: 99%

Oxidative stress in bone remodeling: role of antioxidants

Domazetovic

Marcucci

Iantomasi

et al. 2017

ccmbm

570

524

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SummaryROS are highly reactive molecules which consist of a number of diverse chemical species, including radical and non-radical oxygen species. Oxidative stress occurs as a result of an overproduction of ROS not balanced by an adequate level of antioxidants. The natural antioxidants are: thiol compounds among which GSH is the most representative, and non-thiol compounds such as polyphenols, vitamins and also various enzymes. Many diseases have been linked to oxidative stress including bone diseases among which one of the most important is the osteoporosis. The redox state changes are also related to the bone remodeling process which allows the continuous bone regeneration through the coordinated action of bone cells: osteoclasts, osteoblasts and osteocytes. Changes in ROS and/or antioxidant systems seem to be involved in the pathogenesis of bone loss. ROS induce the apoptosis of osteoblasts and osteocytes, and this favours osteoclastogenesis and inhibits the mineralization and osteogenesis. Excessive osteocyte apoptosis correlates with oxidative stress causing an imbalance in favor of osteoclastogenesis which leads to increased turnover of bone remodeling and bone loss. Antioxidants either directly or by counteracting the action of oxidants contribute to activate the differentiation of osteoblasts, mineralization process and the reduction of osteoclast activity. In fact, a marked decrease in plasma antioxidants was found in aged or osteoporotic women. Some evidence shows a link among nutrients, antioxidant intake and bone health. Recent data demonstrate the antioxidant properties of various nutrients and their influence on bone metabolism. Polyphenols and anthocyanins are the most abundant antioxidants in the diet, and nutritional approaches to antioxidant strategies, in animals or selected groups of patients with osteoporosis or inflammatory bone diseases, suggest the antioxidant use in anti-resorptive therapies for the treatment and prevention of bone loss.

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Section: Oxidative Stress In Bone Remodelingmentioning

confidence: 99%

Oxidative stress in bone remodeling: role of antioxidants

Domazetovic

Marcucci

Iantomasi

et al. 2017

ccmbm

570

524

View full text Add to dashboard Cite

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“…Given this fact, every factor affecting this pathway will influence bone-remodeling cycle. Regarding the pathogenesis of osteoporosis, various investigations have demonstrated the association between inflammation, hormones, growth factors, paracrine and autocrine extractions, homocystein, oxidative stress, and bone fragility (Abdollahi et al 2005;Yousefzadeh et al 2006;Salari et al 2008a, b). In this regard, interleukin-1 (IL-1β) and tumor necrosis factor-α (TNF-α) provoke bone resorption.…”

mentioning

confidence: 99%

The effect of n-3 fatty acids on bone biomarkers in Iranian postmenopausal osteoporotic women: a randomized clinical trial

Salari

Asalforoush

Ameri

et al. 2009

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Recently, n-3 fatty acids are in the center of attention for their potent anti-inflammatory effects. Osteoporosis as a chronic senile disease is associated with inflammation, and the role of inflammatory mediators has been demonstrated in recent years. The beneficial effects of n-3 fatty acids on bone were proven in many animal studies, while to date, no conclusive data is available in human. The aim of this study was to evaluate the impact of n-3 fatty acids on bone biomarkers in osteoporotic postmenopausal women. Twenty-five osteoporotic postmenopausal women were recruited in the study and randomized in treatment and control groups. The patients received 900 mg n-3 fatty acid capsules or placebo per day for 6 months. Serum levels of osteocalcin, bone alkaline phosphatase (BALP), calcium, vitamin D, and parathormone and urine concentration of pyridinoline (Pyd) were measured at baseline, second month, and sixth month in both groups. In the treatment group, compared with baseline, at the second month, osteocalcin increased slightly; thereafter, it showed decrement trend until the end of the study. In the control group, it decreased all over the study. None of these changes was significant. BALP showed nonsignificant decrease from baseline over the time in both groups. Urine level of Pyd decreased significantly (P<0.05) in the treatment group, while no significant change was seen in the control group. Serum calcium and vitamin D increased in both groups; however, changes were not significant. No significant changes were seen in calcium clearance and parathormone. In conclusion, n-3 fatty acids can decrease bone resorption; however, it could not affect bone formation significantly after 6 months treatment. Further investigations are recommended.

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“…Also, lipidic peroxidation, quantified by thiobarbituric acidreactive substances (TBARS), was also higher in both blood and saliva in a group of 22 postmenopausal osteoporotic women (also showing lower antioxidant-capacity) in relation to 22 control ones (Yousefzadeh et al, 2006).…”

Section: Accepted Manuscriptmentioning

confidence: 97%

Serum from postmenopausal women treated with a by-product of olive-oil extraction process stimulates osteoblastogenesis and inhibits adipogenesis in human mesenchymal stem-cells (MSC)

Casado-Díaz

Túnez‐Fiñana

Mata-Granados

et al. 2017

Experimental Gerontology

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Aging may enhance both oxidative stress and bone-marrow mesenchymal stemcell (MSC) differentiation into adipocytes. That reduces osteoblastogenesis, thus favoring bone-mass loss and fracture, representing an important worldwide health-issue, mainly in countries with aging populations. Intake of antioxidant products may help to retain bone-mass density. Interestingly, a novel olivepomace physical treatment to generate olive oil also yields by-products rich in functional antioxidants. Thus, diet of postmenopausal women was supplemented for two months with one of such by-products (distillate 6; D6), being rich in squalene. After treatment, serum from such women showed reduced both lipidic peroxidation and oxidized low-density lipoprotein (LDL). Besides, vitamin E and coenzyme Q10 levels increased. Furthermore, culture medium containing 10% of such serum both increased osteoblastogenesis and reduced adipogenesis in human MSC from bone marrow. Therefore, highly antioxidant by-products like D6 may represent a relevant source for development of functional products, for both prevention and treatment of degenerative pathologies associated with aging, like osteoporosis.

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Determination of Oxidative Stress Status and Concentration of TGF‐β1 in the Blood and Saliva of Osteoporotic Subjects

Cited by 48 publications

References 39 publications

Oxidative stress in bone remodeling: role of antioxidants

Oxidative stress in bone remodeling: role of antioxidants

The effect of n-3 fatty acids on bone biomarkers in Iranian postmenopausal osteoporotic women: a randomized clinical trial

Serum from postmenopausal women treated with a by-product of olive-oil extraction process stimulates osteoblastogenesis and inhibits adipogenesis in human mesenchymal stem-cells (MSC)

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