Determination of reference intervals for total calcium and magnesium specific for children and adolescents in Sibiu area

Antonescu, Elisabeta; Szakács, Juliánna; Totan, Maria

doi:10.1515/rrlm-2016-0030

Cited by 11 publications

(13 citation statements)

References 6 publications

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“…This is the main reason which caused alternative methods to be found and indirect methodologies to be encouraged by IFCC Committee on Reference Intervals and Decision Limits (8). Starting 2013, the Romanian Journal of Laboratory Medicine has published several articles proposing Hoffmann technique (9, 10) for determinations of reference intervals for hemoglobin, serum total magnesium and calcium in Romanian children (11,12), and decision limits for serum uric acid associated with cardiovascular morbidity and metabolic syndrome in this issue (13). On the other hand, by using the reference ranges concept for interpretation of test results there is a grey area where superposition of values from healthy and ill subject exists.…”

Section: Scope Of Laboratory Medicine In the Era Of Precision Medicinmentioning

confidence: 99%

Laboratory medicine in the era of precision medicine – dream or reality?

Dobreanu

Oprea

2019

Revista Romana De Medicina De Laborator

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Section: Scope Of Laboratory Medicine In the Era Of Precision Medicinmentioning

confidence: 99%

Laboratory medicine in the era of precision medicine – dream or reality?

Dobreanu

Oprea

2019

Revista Romana De Medicina De Laborator

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“…For a proper diagnostic it is important to have the values of these hormones correctly determined. [49,50] Testosterone alters neuronal activity, in the sense of increasing dopamine levels and decreasing serotonin levels [51]. Table 1 CORRELATION BETWEEN BPRS VALUES AND BUSS PERRY SCALE associated with the increase of the psychotic symptoms of these patients [62].…”

Section: Resultsmentioning

confidence: 99%

Clinical and Biochemical Correlations of Aggression in Young Patients with Mental Disorders

Duică¹,

Antonescu²,

Pîrlog³

et al. 2018

Rev. Chim.

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Hyperdopaminergia has been identified at impulsive or psychotic patients, the polymorphism of COMT or other enzymes that metabolize dopamine could be involved. The deficiencies of the serotoninergic system in suicidal behaviour has been mentioned by many studies that indicate the reduction of 5-HT, 5-HIAA in CSF or 5-HTT polymorphism. Young patients with psychotic or depression symptoms manifest, frequently, aggressive and self-harm behaviour. Besides the association between the young age and the aggressivity of the patients with serious mental disorders, our study shows gender differences and this matter is sustained by hormonal factors. The study was conducted at the Gheorghe Preda Psychiatric Hospital in Sibiu. The study comprises 52 patients aged between 18 and 35 who were diagnosed with the diagnosis of Schizophrenia, Bipolar Affective Disorder, Depressive Episode and Major depressive disorder according to the DSM-5 criteria. Evaluation of the severity of psychiatric and depressive symptomathology were assessed with Brief Psychiatric Rating Scale and Beck Depression Inventory; aggression and self-aggression in the patients with Schizophrenia, respectively with Bipolar disorder, depressive episode and Major depression disorder were assessed with Buss Perry Aggression Questionnaire and Suicide Intent Scale. Regarding the severity of aggression in the young patients from our study (Buss Perry scale score), male gender is higher than female gender: higher percentages in males (35% and 10%) than in females (16 and 0%). Determining aggression in schizophrenia is possible due to COMT polymorphism that lead to impulsivity or psychotic symptoms. The study show a significant positive correlation between the severity of symptoms of schizophrenia and aggression. From the analysis of the severity of depression in young patients (SIS score) it is noted that its severity is higher in the female gender. Women had higher scores of moderate depression (58%) and severe (26%) than men (37 and 25%, respectively). This relationships could be possible due to the polymorphism of the gene encoding the 5-HTT serotonin transporter related with serotonin deficiency.The study do not show a significant positive correlation between the severity of the depressive symptomatology and the degree of the suicide intent.

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“…The balanced diet and the physical activity can help prevent osteoporosis [22,23]. The calcium intake has a positive effect on bone mass, may reduce the risk of falling and of fracture [24,25,26].…”

Section: Introductionmentioning

confidence: 99%

The importance of physical exercise-bone mass density correlation in reducing the risk of vertebral and non-vertebral fracture in patients with osteoporosis

Silişteanu¹,

Silişteanu²,

Mare³

2018

Balneo

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Introduction. Osteoporosis is a systemic health condition, predominantly in the skeleton, characterized by the decreasing bone strength and bone density as well as by the modification of this structure, being prone to an increased fracture risk. The bone strength of the bone depends on the density and quality of the bone. The bone density was measured by DEXA imagery investigation which uses the dual absorptiometry by X-rays.Material and method. The study was conducted over a period of one year on a total of 30 patients diagnosed with osteoporosis, age 50-70 years. For the assessment of the pain, the visual analogue-VAS scale was used to assess the quality of life-the Qualeffo-41 questionnaire and for assessing fracture risk-the FRAX scorer. The bone mineral density was assessed by the DEXA assay in the lumbar spine and femur using the T score. The patients received pharmacological treatment with bisphosphonates and performed a kinetotherapy program 2 times a week.Results. Patients participating in the study were 60 years old. The repartition depending on the life environment has revealed a greater frequency of the disorder in rural areas than the urban area. The values of the T-student test were statistically significant for the spine (p=0.0006) and for the hip (p=0.03)Conclusions. Research was based on the use of diagnostic utility indices such as bone mineral density, data that correlate with DEXA investigation and fracture risk. Determination of fracture risk with the FRAX score is important in order to identify those patients who need therapy and at the same time to assess the efficiency/cost ratio for the applied therapy. Osteoporosis is a public health problem requiring early diagnosis to optimize therapeutic strategies

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Determination of reference intervals for total calcium and magnesium specific for children and adolescents in Sibiu area

Cited by 11 publications

References 6 publications

Laboratory medicine in the era of precision medicine – dream or reality?

Laboratory medicine in the era of precision medicine – dream or reality?

Clinical and Biochemical Correlations of Aggression in Young Patients with Mental Disorders

The importance of physical exercise-bone mass density correlation in reducing the risk of vertebral and non-vertebral fracture in patients with osteoporosis

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