Determination of the myocardial performance index in deteriorating grades of intrauterine growth restriction and its link to adverse outcomes

Bhorat, Ismail; Bagratee, Jayanthilall; Pillay, Manormoney; Reddy, Tarylee

doi:10.1002/pd.4537

Cited by 40 publications

(51 citation statements)

References 28 publications

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“…In contrast, clinical utility of MPI has been suggested by other studies in Table S1, including recent work of Bhorat et al ,. who found MPI to be 35% higher in FGR cases than in controls as well as higher MPI with worsening FGR, and Nassr et al ,.…”

Section: Discussionmentioning

confidence: 91%

Fetal myocardial performance index in assessment and management of small‐for‐gestational‐age fetus: a cohort and nested case–control study

Henry

Alphonse

Tynan

et al. 2018

Ultrasound in Obstet & Gyne

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MPI did not demonstrate clinical utility in either triage or longitudinal follow-up of an SGA/FGR cohort presenting to fetal medicine services. Given that prior research suggesting its utility originates from single-center cohorts, while multicenter, large cohorts have suggested little utility or no additional utility if routine UA/MCA/DV Doppler is performed, publication bias may have affected previous reports. It seems unlikely that MPI has clinical utility in assessment and management of SGA/FGR fetuses. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.

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Section: Discussionmentioning

confidence: 91%

Fetal myocardial performance index in assessment and management of small‐for‐gestational‐age fetus: a cohort and nested case–control study

Henry

Alphonse

Tynan

et al. 2018

Ultrasound in Obstet & Gyne

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“…In the current study, we found no significant difference between the Mod‐MPI measurements of normal‐growth fetuses vs those of fetuses with FGR. However, many previous studies suggested that this index was useful in FGR . To shed light on the potential utility of the Mod‐MPI, we performed a statistical analysis of data on fetuses with FGR and AED flow on US Doppler evaluations and data obtained from normal‐growth fetuses.…”

Section: Discussionmentioning

confidence: 99%

“…MPI levels are expected to change in the presence of pathological conditions that influence fetal cardiac functions. These include fetal growth restriction (FGR), twin‐twin transfusion syndrome, maternal diabetes mellitus, preeclampsia, fetal hydrops, and fetal anemia . When fetal cardiac functions influence the MPI, it may be important to decide the time of the birth.…”

Section: Introductionmentioning

confidence: 99%

Utility of the modified myocardial performance index in growth‐restricted fetuses

et al. 2019

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Objectives The modified myocardial performance index (Mod‐MPI) can be used to assess myocardial function. Fetal growth restriction can affect fetal myocardial function, thereby altering the Mod‐MPI. The results of previous studies on the utility of the Mod‐MPI in growth‐restricted fetuses are conflicting. The aim of this study was to calculate the left modified‐MPI in growth‐restricted fetuses and to compare the results with those of healthy fetuses. Methods This was a prospective cross‐sectional case–control study. In total, 40 women with growth‐restricted fetuses and 40 women with fetuses of normal weight (controls) at 29–39 gestational weeks were enrolled in the study. An experienced obstetrician calculated the Mod‐MPI for each fetus. Women with systemic diseases or fetuses with chromosomal/structural abnormalities were excluded from the study. The results of Mod‐MPI measurements of the two groups were compared. Results The mean single deepest vertical pocket (SDVP) of amniotic fluid, estimated fetal weight (EFW), and isovolumetric relaxation time (IRT) was significantly lower in the fetal growth restriction (FGR) group as compared with these parameters in the control group (P < .05). The uterine artery (UtA) pulsatility index (PI) was significantly higher in the FGR group as compared with that in the control group (P < .05). There were six cases of absent end‐diastolic flow (AED) in the FGR group. There were no statistically significant between‐group differences in the Mod‐MPI, isovolumetric contraction time (ICT), and ejection time (ET) (P > .05). There was also no statistically significant correlation between the Mod‐MPI in the fetuses with AED and the control group for Mod‐MPI (P > .05). Conclusion The utility of the Mod‐MPI in FGR remains unclear. Future studies with larger populations are needed to determine the utility of the Mod‐MPI as a predictor of cardiac compromise in FGR.

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“…Because of such discrepancies, although many studies have assessed cardiac function in various complicated conditions, their value in clinical practice is limited. Recent studies suggested cut‐off Mod‐MPI values for predicting adverse outcomes in gestational diabetes and IUGR . However, these studies did not describe cursor placement (i.e.…”

Section: Discussionmentioning

confidence: 99%

Fetal left modified myocardial performance index measured by the Auto Mod-MPI system: development of reference values and application to recipients of twin-to-twin transfusion syndrome

et al. 2016

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Determination of the myocardial performance index in deteriorating grades of intrauterine growth restriction and its link to adverse outcomes

Cited by 40 publications

References 28 publications

Fetal myocardial performance index in assessment and management of small‐for‐gestational‐age fetus: a cohort and nested case–control study

Fetal myocardial performance index in assessment and management of small‐for‐gestational‐age fetus: a cohort and nested case–control study

Utility of the modified myocardial performance index in growth‐restricted fetuses

Fetal left modified myocardial performance index measured by the Auto Mod-MPI system: development of reference values and application to recipients of twin-to-twin transfusion syndrome

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