Determination risk factors for severe and profound hearing loss in child candidates for cochlear implantation in southeast of Iran during 2014-2020

Abstract

Background Hearing loss can have a major impact on children’s language development, academic success and hearing comprehension. The aim of the present study was to determinate risk factors for severe and profound hearing loss in child candidates for cochlear implantation in southeast of Iran during 2014–2020. Materials and methods This case-control study consisted of 400 children referring to a cochlear implant center (in southeastern Iran) from Bandar Abbas, Zahedan and Kerman during the years 2014–2020 as cases. The subjects were selected using the random sampling method; 200 children hospitalized in Shafa and Afzalipour hospitals were selected as controls. Results Based on the results of the multivariate logistic regression, weight less than 1500 g (OR = 4.40: p < 0.05), hospitalization in NICU (OR = 7.21: p < 0.05), family history of hearing loss (OR = 11.47: p < 0.05), Gestational age over 35 (OR = 9.63: p < 0.05), intracranial hemorrhage (OR = 5.18: p < 0.05), consanguineous marriage (OR = 12.48: p < 0.05) and high fever and seizures (OR = 3.02: p < 0.05) were recognized as risk factors for sensorineural deafness in children. Conclusion Most of the risk factors for deafness are preventable, and hereditary factors play an important role in congenital deafness in children. Therefore, genetic counseling before consanguineous marriage, early diagnosis, timely intervention can prevent many cases of hearing loss in children.

Genetic counselling considerations with genetic/genomic testing in Neonatal and Pediatric Intensive Care Units: A scoping review

“…A total of 170 articles were included in the final review (alphabetically ordered based on author in Supplementary Table 2). 1,2,7–50,55,56,68–189 A PRISMA flow diagram is presented to track the process and number of studies included and excluded (Figure 1).…”

“…Recurrence risk and prenatal testing for subsequent pregnancies was mentioned in studies published in Iran, 161 Japan, 134 India, 90 Canada, 163 the United Kingdom, 126 and the United States 13 . In Israel and Iran, genetic counselling was “extremely recommended” prior to marriage decisions for ethnicities of Southeastern Iran and Israeli Arab 93,108 . This was to raise awareness of potential consequences of consanguineous marriage and to identify families at risk of transmitting potential heritable disorders 93,108 …”

“…In Israel and Iran, genetic counselling was “extremely recommended” prior to marriage decisions for ethnicities of Southeastern Iran and Israeli Arab 93,108 . This was to raise awareness of potential consequences of consanguineous marriage and to identify families at risk of transmitting potential heritable disorders 93,108 …”

“…13 In Israel and Iran, genetic counselling was "extremely recommended" prior to marriage decisions for ethnicities of Southeastern Iran and Israeli Arab. 93,108 This was to raise awareness of potential consequences of consanguineous marriage and to identify families at risk of transmitting potential heritable disorders. 93,108 North American studies discussed post-genetic testing in NICUs and PICUs for the identification of at-risk family members and clinical follow-up.…”

“…93,108 This was to raise awareness of potential consequences of consanguineous marriage and to identify families at risk of transmitting potential heritable disorders. 93,108 North American studies discussed post-genetic testing in NICUs and PICUs for the identification of at-risk family members and clinical follow-up. 8,44,131,147 Some European studies focused strictly on posttest genetic counselling.…”