2024
DOI: 10.1002/pds.70051
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Determining Targets for Antiretroviral Drug Concentrations: A Causal Framework Illustrated With Pediatric Efavirenz Data From the CHAPAS‐3 Trial

Michael Schomaker,
Paolo Denti,
Andrzej Bienczak
et al.

Abstract: BackgroundDetermining a therapeutic window for maintaining antiretroviral drug concentrations within an appropriate range is required for identifying effective dosing regimens. The limits of this window are typically calculated using predictive models. We propose that target concentrations should instead be calculated based on counterfactual probabilities of relevant outcomes and describe a counterfactual framework for this.MethodsThe proposed framework is applied in an analysis including longitudinal observat… Show more

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