Determining the effectiveness of various treatment modalities in carpal tunnel syndrome by ultrasonography and comparing ultrasonographic findings with other outcomes

Soyupek, Feray; Yeşildağ, Ahmet; Kutluhan, Süleyman; Aşkın, Ayhan; Özden, Ahmet; Uslusoy, Gökçen Ay; Demirci, Seden

doi:10.1007/s00296-011-2173-7

Cited by 28 publications

(26 citation statements)

References 13 publications

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“…Our results were compatible with Uzun’s findings in that the improved symptoms between groups did not correlate with the improvement of electrophysiological measurements. The discordance between symptoms and electrophysiological improvement was expected because routine electrophysiological studies examine mainly large myelinated fibers rather than small sensory fibers which may be responsible for some symptoms of CTS 39 . Indeed, the electrodiagnostic measurement has a limited role in predicting the therapeutic outcome for CTS after surgery and conservative treatment in previous studies 23, 40–42 .…”

Section: Discussionmentioning

confidence: 99%

Six-month efficacy of platelet-rich plasma for carpal tunnel syndrome: A prospective randomized, single-blind controlled trial

Wu¹,

Ho²,

Chou³

et al. 2017

Sci Rep

163

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Recently, a few small reports with short follow-up period have shown clinical benefits of platelet-rich plasma (PRP) for peripheral neuropathy including one pilot study and one small, non-randomized trial in patients with carpal tunnel syndrome (CTS). Therefore, we conducted a randomized, single-blind, controlled trial to assess the 6-month effect of PRP in patients with CTS. Sixty patients with unilateral mild-to-moderate CTS were randomized into two groups of 30, namely the PRP and control groups. In the PRP group, patients were injected with one dose of 3 mL of PRP using ultrasound guidance and the control group received a night splint through the study period. The primary outcome measure was the visual analog scale (VAS) and secondary outcome measures included the Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) score, the cross-sectional area (CSA) of the median nerve (MN), electrophysiological findings of the MN, and finger pinch strength. The evaluation was performed before treatment and at 1, 3, and 6 months post-injection. The PRP group exhibited a significant reduction in the VAS score, BCTQ score, and CSA of MN compared to the those of control group 6 months post-treatment (p < 0.05). Our study demonstrates that PRP is a safe modality that effectively relieves pain and improves disability in the patients with CTS.

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Section: Discussionmentioning

confidence: 99%

Six-month efficacy of platelet-rich plasma for carpal tunnel syndrome: A prospective randomized, single-blind controlled trial

Wu¹,

Ho²,

Chou³

et al. 2017

Sci Rep

163

View full text Add to dashboard Cite

show abstract

“…Twenty RCTs were identified which examined carpal tunnel syndrome [ 134 – 153 ] ( Fig 7 ). Seven studies were excluded from data extraction as they recruited participants with bilateral involvement [ 135 , 137 , 139 , 142 , 143 , 148 , 149 ], which has implications for statistical analysis [ 154 ]. Data was extracted from nine studies, with effect size calculations completed for eight studies ( S4 File ) and odds ratio calculations for three studies ( S5 File ).…”

Section: Resultsmentioning

confidence: 99%

A systematic review of randomised controlled trials assessing effectiveness of prosthetic and orthotic interventions

et al. 2018

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BackgroundAssistive products are items which allow older people and people with disabilities to be able to live a healthy, productive and dignified life. It has been estimated that approximately 1.5% of the world’s population need a prosthesis or orthosis.ObjectiveThe objective of this study was to systematically identify and review the evidence from randomized controlled trials assessing effectiveness and cost-effectiveness of prosthetic and orthotic interventions.MethodsLiterature searches, completed in September 2015, were carried out in fourteen databases between years 1995 and 2015. The search results were independently screened by two reviewers. For the purpose of this manuscript, only randomized controlled trials which examined interventions using orthotic or prosthetic devices were selected for data extraction and synthesis.ResultsA total of 342 randomised controlled trials were identified (319 English language and 23 non-English language). Only 4 of these randomised controlled trials examined prosthetic interventions and the rest examined orthotic interventions. These orthotic interventions were categorised based on the medical conditions/injuries of the participants. From these studies, this review focused on the medical condition/injuries with the highest number of randomised controlled trials (osteoarthritis, fracture, stroke, carpal tunnel syndrome, plantar fasciitis, anterior cruciate ligament, diabetic foot, rheumatoid and juvenile idiopathic arthritis, ankle sprain, cerebral palsy, lateral epicondylitis and low back pain). The included articles were assessed for risk of bias using the Cochrane Risk of Bias tool. Details of the clinical population examined, the type of orthotic/prosthetic intervention, the comparator/s and the outcome measures were extracted. Effect sizes and odds ratios were calculated for all outcome measures, where possible.ConclusionsAt present, for prosthetic and orthotic interventions, the scientific literature does not provide sufficient high quality research to allow strong conclusions on their effectiveness and cost-effectiveness.

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“…Some authors suggested a close relationship [26, 27], while others proposed the opposite [28]. However, these variations are expected considering that routine electrophysiological tests mainly examine large myelinated fibers rather than small sensory fibers that may be responsible for some symptoms of CTS [29]. In our study, change in SNCV of the median nerve does not support this relationship, although significant improvement of VAS and BCTQ scores, CSA of the median nerve, and finger pinch strength was observed in both groups.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-Guided Pulsed Radiofrequency for Carpal Tunnel Syndrome: A Single-Blinded Randomized Controlled Study

Sun

Lee

et al. 2015

PLoS ONE

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ObjectiveWe assessed the therapeutic efficiency of ultrasound-guided pulsed radiofrequency (PRF) treatment of the median nerve in patients with carpal tunnel syndrome (CTS).MethodsWe conducted a prospective, randomized, controlled, single-blinded study. Forty-four patients with CTS were randomized into intervention or control groups. Patients in the intervention group were treated with PRF and night splint, and the control group was prescribed night splint alone. Primary outcome was the onset time of significant pain relief assessed using the visual analog scale (VAS), and secondary outcomes included evaluation of the Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) results, cross-sectional area (CSA) of the median nerve, sensory nerve conduction velocity (SNCV) of the median nerve, and finger pinch strength. All outcome measurements were performed at 1, 4, 8, and 12 weeks after treatment.ResultsThirty-six patients completed the study. The onset time of pain relief in the intervention group was significantly shorter (median onset time of 2 days vs. 14 days; hazard ratio = 7.37; 95% CI, 3.04–17.87) compared to the control group (p < 0.001). Significant improvement in VAS and BCTQ scores (p < 0.05) was detected in the intervention group at all follow-up periods compared to the controls (except for the severity subscale of BCTQ at week 1). Ultrasound-guided PRF treatment resulted in a lower VAS score and stronger finger pinch compared to the control group over the entire study.ConclusionsOur study shows that ultrasound-guided PRF serves as a better approach for pain relief in patients with CTS.Trial RegistrationClinicalTrials.gov NCT02217293

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Determining the effectiveness of various treatment modalities in carpal tunnel syndrome by ultrasonography and comparing ultrasonographic findings with other outcomes

Cited by 28 publications

References 13 publications

Six-month efficacy of platelet-rich plasma for carpal tunnel syndrome: A prospective randomized, single-blind controlled trial

Six-month efficacy of platelet-rich plasma for carpal tunnel syndrome: A prospective randomized, single-blind controlled trial

A systematic review of randomised controlled trials assessing effectiveness of prosthetic and orthotic interventions

Ultrasound-Guided Pulsed Radiofrequency for Carpal Tunnel Syndrome: A Single-Blinded Randomized Controlled Study

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