Determining the epidemiologic, outcome, and prognostic factors of oral malignant melanoma by using the Surveillance, Epidemiology, and End Results database

Lee, Robert J.; Lee, Serena A.; Lin, Thomas S.; Lee, Kevin K.; Christensen, Robert E.

doi:10.1016/j.adaj.2017.01.019

Cited by 12 publications

(11 citation statements)

References 44 publications

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“…Mucosal melanoma is typically aggressive and is associated with a poor prognosis. Retrospective analysis of Surveillance, Epidemiology, and End Results data from 1973‐2012 indicates that the 5‐year OS rate is approximately 25% among patients with oral mucosal melanoma . Photon RT is an option as adjuvant or definitive treatment, although mucosal melanoma is also considered radioresistant, and Wushou et al reported that the 3‐year OS rate was 0% among 21 patients with primary oral mucosal melanoma treated using RT .…”

Section: Discussionmentioning

confidence: 99%

“…Retrospective analysis of Surveillance, Epidemiology, and End Results data from 1973-2012 indicates that the 5-year OS rate is approximately 25% among patients with oral mucosal melanoma. 29 Photon RT is an option as adjuvant or definitive treatment, although mucosal melanoma is also considered radioresistant, and Wushou et al reported that the 3-year OS rate was 0% among 21 patients with primary oral mucosal melanoma treated using RT. 5 Interestingly, C-ion RT appears to provide benefits in terms of local control and survival relative to photon RT, as we reported 5-year rates of 89.4% for local control and 57.4% for OS among 19 patients who only received Cion RT for oral mucosal melanomas.…”

Section: Discussionmentioning

confidence: 99%

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Feasibility of carbon‐ion radiotherapy for oral non‐squamous cell carcinomas

et al. 2019

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Background This study evaluated carbon‐ion radiotherapy (C‐ion RT) for oral non‐squamous cell carcinomas (non‐SCC). Methods We retrospectively obtained data from 74 patients who underwent C‐ion RT for oral malignancies between April 1997 and March 2016. The C‐ion RT was administered in 16 fractions at a total dose of 57.6 or 64.0 Gy (relative biological effectiveness). Results Forty‐three patients had salivary gland carcinomas, 29 patients had mucosal melanoma, and 2 patients had other types of pathologies. The tumors were classified as T1‐T3 (24 cases), T4a (21 cases), or T4b (29 cases). The median follow‐up was 49 months. The 5‐year rates were 78.8% for local control, 36.2% for progression‐free survival, and 58.3% for overall survival. Although 10 patients developed grade 3 osteoradionecrosis after C‐ion RT, all patients maintained their mastication and deglutition functions after sequestrectomy and prosthesis placement. Conclusion C‐ion RT was effective for oral non‐SCC and had acceptable toxicities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Feasibility of carbon‐ion radiotherapy for oral non‐squamous cell carcinomas

et al. 2019

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“…The rare disease of mucosal melanoma of the oral cavity has consistently been associated with a poor outcome. Surveillance, epidemiology, and end results data from the period of 1973‐2012 have indicated a 5‐year OS rate of approximately 25% among patients with oral mucosal melanoma . Complete surgical resection with clear margins is the pillar of oral mucosal melanoma management, and optimal results might be expected.…”

Section: Discussionmentioning

confidence: 99%

“…Surveillance, epidemiology, and end results data from the period of 1973-2012 have indicated a 5-year OS rate of approximately 25% among patients with oral mucosal melanoma. 20 Complete surgical resection with clear margins is the pillar of oral mucosal melanoma management, and optimal results might be expected. However, it is frequently difficult for oral mucosal melanoma to keep a tumor-free surgical margin of 1-2 cm, which is generally required and accepted for cutaneous melanoma, as the extent of histopathologically assessed tumor expanse is usually greater than that of the gross disease, and it might include the pharynx and paranasal sinus.…”

Section: Factorsmentioning

confidence: 99%

Multicenter study of carbon‐ion radiation therapy for nonsquamous cell carcinomas of the oral cavity

et al. 2019

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Background The aim of this study was to evaluate the efficacy and safety of carbon‐ion radiation therapy for nonsquamous cell carcinomas of the oral cavity in a multicenter study. Methods Retrospective analysis of the clinicopathological features and outcomes of 76 patients with oral nonsquamous cell carcinomas with N0‐1 M0 status and were treated with carbon‐ion radiation therapy at four institutions in Japan between November 2003 and December 2014 was performed. Results Salivary gland carcinoma, mucosal melanoma, and three other carcinomas were found in 46, 27, and 3 patients, respectively. T1‐3, T4a, and T4b disease was diagnosed in 27, 18, and 31 patients, respectively. Median follow‐up period was 31.1 months (range, 3‐118 months). Three‐year local control, progression‐free survival, and overall survival of all patients were 86.8%, 63.1%, and 78.4%, respectively. Multivariate analysis showed T classification (T4) to be a significant independent poor prognostic factor for local control. Acute grade 3 mucositis was observed in 38 patients. Grades 3 and 4 late morbidities were observed in 9 and 4 patients, respectively. No grade 5 late toxicity was observed. Conclusions Oral nonsquamous cell carcinomas could be treated effectively, with acceptable toxicity, by carbon‐ion radiation therapy.

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“…When this time is short it permits a less aggressive and mutilating treatment, in addition to increasing the chance of survival. 17 The period of time until treatment includes the beginning of symptoms felt by the patient, looking for a professional, the final diagnosis and the beginning of therapy. There are two characteristics in this story: the patient himself and the health professional.…”

Section: Discussionmentioning

confidence: 99%

Awareness for need of improvement in knowledgement about oral lesions for professionals in primary health care

Alves

Macedo

Mestriner

et al. 2019

Rev. Bras. Odontol.

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Objetivo: O objetivo desse estudo foi avaliar a eficácia do diagnóstico e tratamento de lesões orais entre diferentes níveis de saúde. Material e Métodos: Todas as informações foram obtidas dos prontuários médicos de um Hospital Universitário e de fichas do Sistema Público de Regulação, considerando as características clínico-demográficas tal como, doenças orais diagnosticadas, sistema de referência e terapia empregada. A avaliação foi baseada na relação entre diagnóstico final, hipótese diagnóstica e prioridade para agendamento da consulta, também foi considerado o tempo decorrido entre o encaminhamento e o primeiro atendimento, data do diagnóstico final e início da terapia. Depois, a hipótese diagnóstica preenchida por profissionais de saúde do nível primário e terciário foram comparadas e a concordância entre ambos foi determinada. Resultados: Cerca de 51% dos encaminhamentos preenchidos pelos profissionais da atenção primária estavam incompletos, ou a hipótese diagnóstica estava descrita de forma inadequada. No nível terciário, o tempo médio entre o encaminhamento e a primeira consulta foi de 23 dias, a média entre o diagnóstico final e o início do tratamento foi de 22 dias. O tratamento cirúrgico foi o mais rápido (31 dias) quando comparado a radioterapia para lesões malignas (81 a 100 dias). Conclusão: É necessário melhorar o treinamento de profissionais de saúde da Atenção Básica no reconhecimento de lesões orais malignas. Claramente, o preenchimento adequado das hipóteses de diagnóstico, com o grau de prioridade correspondente acelera o diagnóstico e tratamento do paciente.

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Determining the epidemiologic, outcome, and prognostic factors of oral malignant melanoma by using the Surveillance, Epidemiology, and End Results database

Cited by 12 publications

References 44 publications

Feasibility of carbon‐ion radiotherapy for oral non‐squamous cell carcinomas

Feasibility of carbon‐ion radiotherapy for oral non‐squamous cell carcinomas

Multicenter study of carbon‐ion radiation therapy for nonsquamous cell carcinomas of the oral cavity

Awareness for need of improvement in knowledgement about oral lesions for professionals in primary health care

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