Detoxification of Mercury by Selenium by Binding of Equimolar Hg–Se Complex to a Specific Plasma Protein

Yoneda, Shinji; Suzuki, Kazuo

doi:10.1006/taap.1996.8095

Cited by 142 publications

(84 citation statements)

References 20 publications

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“…Besides, the ability of selenium to reduce mercury toxicity has been extensively investigated 20,21) . Most studies have evaluated the effects of the inorganic selenium compound (sodium selenite) on mercury toxicity 9,11,[22][23][24][25] . In the presence of selenium, the accumulation of mercury in the target organ kidney is reported to be reduced, but body retention of mercury on the whole is increased, especially in the liver 20) .…”

Section: Introductionmentioning

confidence: 99%

Role of Selenium in Mercury Intoxication in Mice

Agarwal

Behari

2007

Ind Health

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Studies were conducted to examine the effect of pre and post-treatment of selenium in mercury intoxication (20 µ µ µ µ µmole/ kg b.w. each given intraperitoneally) in mice in terms of lipid peroxidation (LPO), glutathione (GSH) content, activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and mercury concentration in liver, kidney and brain. No significant alteration was observed in all the organs examined after mercury or selenium treatment in LPO and GSH but administration of selenium (pre and post) resulted in an increase in the level of LPO and GSH. The activity of SOD was depleted in liver and kidney while that of GPx was lowered in liver of mercury exposed animals. Selenium administration resulted in restoration of the depletion of these enzymatic activities. The activity of CAT in liver and brain was enhanced both in mercury and selenium treated animals. Administration of selenium significantly arrested enhanced CAT activity. Kidney showed the highest mercury concentration among the organs examined. Administration of selenium resulted in further enhancement of mercury concentration in the tissues. An increase in selenium level in liver was observed after mercury treatment, which was also restored by mercury selenium co-administration. Our results indicate that the prooxidant effect of selenium was greater by its pretreatment.

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Section: Introductionmentioning

confidence: 99%

Role of Selenium in Mercury Intoxication in Mice

Agarwal

Behari

2007

Ind Health

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“…One source of uncertainty arises from the lack of accompanying data on other trace elements like Se or Ca, which might attenuate the potential harm associated with exposure to Hg (Sakamoto et al, 1996;Yoneda and Suzuki, 1997;Osman et al, 1998;Vasconcellos et al, 2000). Also, for the fish intake pathway the sample of average concentrations is small, the mercury analyzed in the fish is total mercury (and the MeHg concentration could be as much as 10% lower), and a Gl absorption rate of 100% for MeHg, was considered while a more prudent assumption used by USEPA is 95% (thus the fish-intake risk might be discounted by as much as 5%).…”

Section: Resultsmentioning

confidence: 99%

Probabilistic meta-analysis of risk from the exposure to Hg in artisanal gold mining communities in Colombia

et al. 2014

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HIGHLIGHTSo Data of Hg in air and in fish across Colombia are evaluated in terms of risk. o Probability distribution functions are fitted to exposure and concentration data. o lnhalation of Hg contributes more to the overall risk than ingestion of fish. o The risk for the residents of mining communities greatly exceeds the threshold of 1. o The risk for miner-smelters is 200 times higher than what is deemed acceptable. A B S T R A C TColombia is one of the largest per capita mercury polluters in the world as a consequence of its artisanal gold mining activities. The severity of this problem in terms of potential health effects was evaluated by means of a probabilistic risk assessment carried out in the twelve departments (or provinces) in Colombia with the largest gold production. The two exposure pathways included in the risk assessment were inhalation of elemental Hg vapors and ingestion of fish contaminated with methyl mercury. Exposure parameters for the adult population (especially rates of fish consumption) were obtained from nation-wide surveys and concentrations of Hg in air and of methyl-mercury in fish were gathered from previous scientific studies. Fish consumption varied between departments and ranged from O to 0.3 kg d 1. Average concentrations oftotal mercury in fish (70 data) ranged from 0.026 to 3.3 I-lg g 1. A total of 550 individual measurements of Hg in workshop air (ranging from

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“…The administration of selenite at a lethal dose antagonized the lethal dose of iHg in experimental animals (Naganuma et al, 1984;Su et al, 2008;Yoneda and Suzuki, 1997). Good positive correlation was noted between Se and Hg concentrations in the livers of marine mammals and seabirds, which highly accumulated Hg in their liv-ers (Kim et al, 1996;Storelli et al, 1998;Woshner et al, 2001).…”

Section: Introductionmentioning

confidence: 92%

Comparison of selenoneine found in marine organisms with selenite in the interaction with mercury compounds in vitro

2011

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-Selenium (Se) is an essential micronutrient because it forms the active center of selenoenzymes/selenoproteins in the form of selenocysteine. Another biological significance of Se is that it detoxifies inorganic mercury (iHg) by directly interacting with it. Recently, a novel selenometabolite, selenoneine (2-selenyl-N,N,N-trimethyl-L-histidine), was identified in several marine animals. However, its biological significance is still unclear. In this study, the ability of selenoneine to form a complex with iHg and methyl Hg (MeHg) was evaluated in vitro. Whereas selenite serving as the positive control reacted with iHg by direct interaction after being converted into selenide by endogenous reductants, such as glutathione (GSH), selenoneine did not interact with iHg or MeHg in the liver homogenate of marine turtle. This indicates that selenoneine may not play a role in the detoxification of Hg.

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Detoxification of Mercury by Selenium by Binding of Equimolar Hg–Se Complex to a Specific Plasma Protein

Cited by 142 publications

References 20 publications

Role of Selenium in Mercury Intoxication in Mice

Role of Selenium in Mercury Intoxication in Mice

Probabilistic meta-analysis of risk from the exposure to Hg in artisanal gold mining communities in Colombia

Comparison of selenoneine found in marine organisms with selenite in the interaction with mercury compounds in vitro

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