Detrusor botulinum toxin A injection significantly decreased urinary tract infection in patients with traumatic spinal cord injury

Chen, Jia; Lm, Liao; Chen, G; Sui, Yi

doi:10.1038/sc.2012.180

Cited by 39 publications

(18 citation statements)

References 20 publications

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“…In addition, detrusor overactivity per se is linked to an increase in UTI frequency. 29 Therefore, the need to alter treatments for detrusor overactivity during pregnancy may increase the risk of having UTIs. Patients with Brindley stimulators neither performed intermittent catheterisation nor received treatment for detrusor overactivity.…”

Section: Discussionmentioning

confidence: 99%

Medical complications during pregnancy and childbirth in women with SCI in Switzerland

et al. 2015

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Study design: A retrospective interview study of mothers with spinal cord injuries (SCIs) who gave birth over the last 15 years. Objectives: To identify the medical complications of women with SCIs during pregnancy and childbirth in Switzerland and to describe how they dealt with these complications. Settings: Swiss Paraplegic Research in Nottwil, the University of Lausanne and participants' homes. Methods: Data were collected by self-reported questionnaires and descriptive analysis was conducted. Results: Seventeen women with SCIs who gave birth to 23 children were included. Thirteen of the women were paraplegics and four were tetraplegics. All of them practiced an independent bladder management. Three women changed their bladder management techniques during pregnancy. Five women reported an increased bladder evacuation frequency during pregnancy, and six women reported a new onset or increase in incontinence. We observed no significant increase in bowel dysfunction or skin breakdown due to their pregnancies. Ten women were hospitalised during the course of their pregnancies. Aside from urinary tract infections/ pyelonephritis, women were hospitalised for falls, hypertension, pneumonia, preeclampsia, pre-term labour or tachycardia. Conclusion:The results of our study clearly demonstrated that, although medical complications are not infrequent during pregnancy in women with SCIs, pregnancy and delivery in this group of women are possible without posing intolerable risks to the mothers or the children. Urological problems seemed to be the most frequent complication during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Medical complications during pregnancy and childbirth in women with SCI in Switzerland

et al. 2015

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“…This will result in secondary cell death for a time period ranging from several days to weeks. Thus, it will cause massive death of neurons and glia cells after primary injury (5). The severity of multifactorial sequence tissue destruction is even greater than that of primary injury.…”

Section: Introductionmentioning

confidence: 99%

Thymoquinone reduces spinal cord injury by inhibiting inflammatory response, oxidative stress and apoptosis via PPAR‑γ and PI3K/Akt pathways

2018

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The present study used a mild contusion injury in rat spinal cord to determine that thymoquinone reduces inflammatory response, oxidative stress and apoptosis in a spinal cord injury (SCI) rat model and to demonstrate its possible molecular mechanisms. The rats in the thymoquinone group received 30 mg/kg thymoquinone once daily by intragastric administration from 3 weeks after surgery. Hematoxylin and eosin staining, Basso, Beattie and Bresnahan (BBB) scale and tissue water content detection were used in the present study to analyze the effect of thymoquinone on SCI. The activity of inflammatory response mediators, oxidative stress factors and caspase-3/9 was measured using ELISA kits. Furthermore, western blotting was performed to analyzed the protein expression levels of prostaglandin E2, suppressed cyclooxygenase-2 (COX-2) and activated peroxisome proliferator-activated receptor γ (PPAR-γ), PI3K and Akt. The results from the study demonstrated that thymoquinone increased Basso, Beattie and Bresnahan score and decreased water content in spinal cord tissue. Treatment with thymoquinone decreased inflammatory response [measured by levels of tumor necrosis factor α, interleukin (IL)-1β, IL-6 and IL-18], oxidative stress (measured by levels of superoxide dismutase, catalase, glutathione and malondialdehyde) and cell apoptosis (measured by levels of caspase-3 and caspase-9) in SCI rats. Thymoquinone treatment inhibited prostaglandin E2 activity, suppressed COX-2 protein expression and activated PPAR-γ, PI3K and p-Akt protein expression in SCI rats. These data revealed that thymoquinone reduces inflammatory response, oxidative stress and apoptosis via PPAR-γ and PI3K/Akt pathways in an SCI rat model.

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“…The total number of UTIs in the cohort decreased from 57 to 32 after injection (P 5 .023). 64 These results should be corroborated in a large, well-designed study, but, aside from the small risk of UTI immediately after instrumentation for administration of the therapeutic, 65 intravesical injection of onabotulinum toxin A may prove to be useful for UTI risk reduction in NGB.…”

Section: Onabotulinum Toxin Amentioning

confidence: 82%

Urinary Tract Infection and Neurogenic Bladder

McKibben

Seed

Ross

et al. 2015

Urologic Clinics of North America

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Detrusor botulinum toxin A injection significantly decreased urinary tract infection in patients with traumatic spinal cord injury

Cited by 39 publications

References 20 publications

Medical complications during pregnancy and childbirth in women with SCI in Switzerland

Medical complications during pregnancy and childbirth in women with SCI in Switzerland

Thymoquinone reduces spinal cord injury by inhibiting inflammatory response, oxidative stress and apoptosis via PPAR‑γ and PI3K/Akt pathways

Urinary Tract Infection and Neurogenic Bladder

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