Devastating renal outcome caused by skin infection with methicillin-resistant Staphylococcus aureus

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is an emerging pathogen that infects the skin and soft tissue. However, there are few reports of renal complications from MRSA involving immunoglobulin (Ig)A-dominated rapidly progressive glomerulonephritis (GN). Favorable renal outcomes from IgA GN are achieved by administering timely therapy. In the present study, we describe the case of a healthy young woman suffering from a cutaneous MRSA infection that initially presented with gross hematuria. Six months after eradicating the infection, severe impairment of renal function was noted because of intractable nausea and vomiting. Renal pathology revealed advanced IgA nephropathy with fibrocellular crescent formation. An aggressive treatment plan using immunosuppressants was not adopted because of her irreversible renal pathology, and she was therefore administered maintenance hemodialysis.This instructive case stresses the importance of being aware of the signs of IgA nephropathy post-MRSA infection, such as cutaneous lesions that are mostly painless and accompanied by hematuria and mild proteinuria. If the kidney cannot be salvaged, it will undergo irreversible damage with devastating consequences.

Prevalence of Meticillin Resistance Staphylococcus Aureus in Patients with Lower Respiratory Tract Infections

“…Community -associated MRSA infection can pose hazardous effect on health but the major concern is that, it may have devastating consequences, if it becomes epidemic in resource poor regions. [8] HA-MRSA is a highly resistant nosocomial pathogen in both acute and chronic infections. It is associated with increased morbidity and mortality when compared with CA-MRSA.…”