Developed a novel sensor based on fluorescent graft conjugated polymer for the determination of aristolochic acid in traditional Chinese medicine

Liu, Jilin; Xu, Chunling; Yang, Ting; Hu, Zhiru; Zhang, Zhiquan; Feng, Guodong

doi:10.1016/j.saa.2019.117239

Cited by 18 publications

(8 citation statements)

References 36 publications

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“…According to the results, LODs of the four Ln-MOFs to the six compounds were obtained around 10 −11 to 10 −10 M. According to the reports, the LOD of Tb x Eu 1−x -CTP-COOH for Fe 3+ was 3.86 μM, 48 which suggests that the Ln-MOFs may be better suited to detect natural compounds. Also, the LODs of many fluorescent sensors for natural medicine were above 10 −8 M, 50,51 indicating the high sensitivity of our sensor array. Those results demonstrated that the four Ln-MOFs might be developed as a promising sensor.…”

Section: ■ Results and Discussionmentioning

confidence: 83%

Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine

Yin

Zheng

et al. 2021

Langmuir

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The discrimination and quantification of the ingredients from natural medicines are a challenging issue due to their complicated and various structures. Metal–organic frameworks (MOFs) have shown great promise in sensing applications. Here, we report a fluorescent sensor array for rapid identification of some natural compounds using a sensor array composed of four kinds of lanthanide (Eu3+ and Tb3+) fluorescent MOFs (Ln-MOFs), which have diversified fluorescent responses to 26 active/toxic compounds including 12 saponins, 7 flavonoids, 3 stilbenes, and 4 anthraquinones. The fluorescence of the Ln-MOFs after reaction with the compounds was summarized as datasets and processed by principle component analysis (PCA) and hierarchical cluster analysis (HCA) methods. The corresponding responses of the 4 types of compounds are well separated on 2D/3D PCA score plots and HCA dendrograms. We have also tested typical blind samples by concentration-dependent PCA, and an accuracy of 100% was obtained. In addition, the response mechanisms of the Ln-MOFs to the compounds were also studied. Compared with traditional methods using liquid chromatography-mass spectrometry, the developed fluorescent sensor array provides a more efficient and economic strategy to discriminate various active/toxic ingredients in natural medicine.

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Section: ■ Results and Discussionmentioning

confidence: 83%

Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine

Yin

Zheng

et al. 2021

Langmuir

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“…To emphasize the advantage of the proposed sensor in this work, the performance of the TzDA−BTAN−COF was compared with different fluorescence sensors for the detection of PA, AAS, and OFLX (Table 1). Compared with the Lys-AuNCs Zn-MOF, 45 PPE-OB-PEG, 46 BSA-AuNCs, 47 and TPEbased LMOF 48 sensors for detecting AAS and other listed fluorescence sensors for detecting PA, the TzDA−BTAN− COF had a lower LOD and wider linear range. Meanwhile, the LOD and linear range of the TzDA−BTAN−COF for the detection of OFLX was preferable to the Cys-CuNCs-Fe 3+ , 49 β-CD-N, Zn-CDs, 50 magnetic-MWCNT nanocomposites, and graphene quantum dots.…”

Section: ■ Results and Discussionmentioning

confidence: 97%

Dual Functional sp² Carbon-Conjugated Nanoporous Covalent Organic Framework as a Janus Fluorescence Sensor for the Detection of Hazardous Substances

Qiao

Han

et al. 2022

ACS Appl. Nano Mater.

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Constructing a luminescent covalent organic framework (LCOF) via an ultrasound-assisted one-step reaction used for “one to many” recognition of targets is a challenge. In this work, we report a fluorescent sp2c-covalent organic framework (COF) (TzDA–BTAN–COF) containing a regular nanoporous structure, uninterrupted π-electron delocalization, and an electron-deficient unit. We explore the use of the TzDA–BTAN–COF for the visual inspection and fluorescent quantitative analyses of hazardous substances. The TzDA–BTAN–COF, as a Janus sensor, exhibited double nature with different fluorescence properties: “turn-on” and “turn-off.” Fluorescence enhancement was exhibited in the presence of electron-rich ofloxacin (OFLX) and fluorescence quenching in the presence of electron-deficient picric acid (PA) and aristolochic acid (AAS). The fluorescence-on and -off sensing mechanism might be attributed to the photoinduced electron transfer by the electron transfer from the donor to the acceptor based on theoretical calculations. In addition, the TzDA–BTAN–COF has been used for the highly sensitive fluorescence detection of PA, AAS, and OFLX. It exhibited good linearity toward PA, AAS, and OFLX over the range from 0.1 to 80, 0.01 to 100, and 0.01 to 1 μg mL–1 with a limited detection of 32.1, 3.3, and 3.0 ng mL–1, respectively. Meanwhile, the real samples were measured, with satisfactory recoveries (95.0–105.5%) and reliable analytical results. The TzDA–BTAN–COF is the first nanoporous COF Janus fluorescence sensor for the “one to many” recognition and fluorescence detection of different hazardous substances by dual functional fluorescence-on and -off sensing.

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“…其中, Sonogashira 反应是常用于构建有机聚合物荧光传感器的金属偶联反应之一 [17] . Sonogashira 反应是在钯配合物催化下卤代芳烃或卤代烯烃与末端炔烃的交叉偶联反应, 常用于合成潜在药物分子 [18][19] 和有机荧光聚合物 [20] 等. 例如, Jones 课题组 [21][22] 利用二溴代噻吩衍生物和二炔基苯发生的 Sonogashira 反应, 合成了可用于金属离子检测的共轭有机聚合物 (Eq.…”

Section: 基于直接聚合法的有机聚合物荧光传感器unclassified

Research Progress of Organic Polymer Fluorescence Sensor

Cao¹,

Luo²,

Yang³

et al. 2020

Chin. J. Org. Chem.

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Organic fluorescent polymers have unique characteristics of fluorescent signal amplification and good optical properties, and can detect specific analytical species. Their sensing performance can be further improved through reasonable modification of their side chains. Nowadays, the organic fluorescent polymers are mainly prepared by metal coupling reactions, and there are also some syntheses involving in addition polymerization and condensation reactions. Taking the fluorescent source of these polymers as the main line, the research progress of the fluorescent organic polymers in the sensor field in recent years is systematically reviewed from the perspective of the type of reaction, especially their design and synthesis, sensing application, detection mechanism are summarized. In the future, it is still to be further investigated to design and synthesize novel multifunctional organic polymer fluorescence sensors as the key development direction.

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Developed a novel sensor based on fluorescent graft conjugated polymer for the determination of aristolochic acid in traditional Chinese medicine

Cited by 18 publications

References 36 publications

Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine

Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine

Dual Functional sp² Carbon-Conjugated Nanoporous Covalent Organic Framework as a Janus Fluorescence Sensor for the Detection of Hazardous Substances

Research Progress of Organic Polymer Fluorescence Sensor

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Developed a novel sensor based on fluorescent graft conjugated polymer for the determination of aristolochic acid in traditional Chinese medicine

Cited by 18 publications

References 36 publications

Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine

Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine

Dual Functional sp2 Carbon-Conjugated Nanoporous Covalent Organic Framework as a Janus Fluorescence Sensor for the Detection of Hazardous Substances

Research Progress of Organic Polymer Fluorescence Sensor

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Dual Functional sp² Carbon-Conjugated Nanoporous Covalent Organic Framework as a Janus Fluorescence Sensor for the Detection of Hazardous Substances