Developing an Instrumental Activities of Daily Living Tool as Part of the Low Vision Assessment of Daily Activities Protocol

Finger, Robert P.; McSweeney, Shane; Deverell, Lil; O’Hare, Fleur; Bentley, Sharon A; Luu, Chi D; Guymer, Robyn H.; Ayton, Lauren N

doi:10.1167/iovs.14-14732

Cited by 33 publications

(25 citation statements)

References 44 publications

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“…Improvements in vision-related quality of life and real-world function have been reported in larger cohorts with the Argus II epiretinal prosthesis. 13 , 14 Although no head-to-head trial between the 2 devices has been conducted, introduction of standardized assessment protocols for extreme low vision 15 , 16 may facilitate future comparison between different retinal prostheses. There are presently no data available on clinical trial outcomes for the IRIS II device.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Electronic Retinal Implant Alpha AMS in Restoring Vision to Blind Patients with End-Stage Retinitis Pigmentosa

et al. 2018

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PurposeTo report the initial efficacy results of the Retina Implant Alpha AMS (Retina Implant AG, Reutlingen, Germany) for partial restoration of vision in end-stage retinitis pigmentosa (RP).DesignProspective, single-arm, investigator-sponsored interventional clinical trial. Within-participant control comprising residual vision with the retinal implant switched ON versus OFF in the implanted eye.ParticipantsThe Retina Implant Alpha AMS was implanted into the worse-seeing eye of 6 participants with end-stage RP and no useful perception of light vision. Eligibility criteria included previous normal vision for ≥12 years and no significant ocular or systemic comorbidity.MethodsVision assessments were scheduled at 1, 2, 3, 6, 9, and 12 months postimplantation. They comprised tabletop object recognition tasks, a self-assessment mobility questionnaire, and screen-based tests including Basic Light and Motion (BaLM), grating acuity, and greyscale contrast discrimination. A full-field stimulus test (FST) was also performed.Main Outcome MeasuresImprovement in activities of daily living, recognition tasks, and assessments of light perception with the implant ON compared with OFF.ResultsAll 6 participants underwent successful implantation. Light perception and temporal resolution with the implant ON were achieved in all participants. Light localization was achieved with the implant ON in all but 1 participant (P4) in whom the chip was not functioning optimally because of a combination of iatrogenic intraoperative implant damage and incorrect implantation. Implant ON correct grating detections (which were at chance level with implant OFF) were recorded in the other 5 participants, ranging from 0.1 to 3.33 cycles/degree on 1 occasion. The ability to locate high-contrast tabletop objects not seen with the implant OFF was partially restored with the implant ON in all but 1 participant (P4). There were 2 incidents of conjunctival erosion and 1 inferotemporal macula-on retinal detachment, which were successfully repaired, and 2 incidents of inadvertent damage to the implant during surgery (P3 and P4).ConclusionsThe Alpha AMS subretinal implant improved visual performance in 5 of 6 participants and has exhibited ongoing function for up to 24 months. Although implantation surgery remains challenging, new developments such as OCT microscope guidance added refinements to the surgical technique.

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Section: Discussionmentioning

confidence: 99%

Assessment of the Electronic Retinal Implant Alpha AMS in Restoring Vision to Blind Patients with End-Stage Retinitis Pigmentosa

et al. 2018

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“…The IVI was designed to assess participation in vision-dependent daily activities and has been used to assess the effectiveness of ophthalmic treatment and low vision rehabilitation. 13–18 As part of the original work, factor analysis suggested there are three separate subscales on the IVI VFQ, “Reading and Accessing Information” (nine items), “Mobility and Independence” (11 items), and “Emotional Well-being” (eight items). 18…”

Section: Introductionmentioning

confidence: 99%

Calibrating the Impact of Vision Impairment (IVI): Creation of a Sample-Independent Visual Function Measure for Patient-Centered Outcomes Research

Goldstein

Fenwick

Finger

et al. 2018

Trans. Vis. Sci. Tech.

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PurposeProvide item calibrations estimated for the Impact of Vision Impairment (IVI) questionnaire by pooling data from several studies of people with vision impairment (VI) representing a variety of countries and causes of VI.MethodsEight data sets from six principal investigators representing responses to IVI items from 2867 VI patients were pooled for analysis. Eligible patients were 18 years or older and from Australia, India, and the United States. Rasch analysis, using the Andrich Rating Scale Model (Winsteps version 3.65), was performed on preintervention IVI responses to estimate item and person measures, reliability coefficients, and response category thresholds. Differential item functioning (DIF) analysis and analysis of variance (ANOVA) were used to examine the effects different data sets and covariates on item estimates.ResultsPatient age range was 18 to 103 years (median 62 years); 55% were male. Visual acuity ranged from 20/20 to no light perception and primary diagnosis was macular degeneration in 29% of patients. Item measure estimates showed good separation reliability (R2 = 0.99). DIF magnitude did not preclude use of all IVI-28 data. ANOVA showed VA (P < 0.001) and gender (P < 0.002) were predictors of visual ability.ConclusionsAnalysis from pooled data support the provision of calibrated IVI item measures for researchers and clinicians to use, thus better enabling direct comparisons of patients with VI.Translational RelevanceValidity testing of the IVI show that we can combine disparate data sets of patient responses to calibrate item measures and response category thresholds, and provide to others for use in comparing patients across clinical trials and on an individual basis.

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“…IADL-VLV (Finger et al 98 ): Finger and colleagues used Delphi survey techniques to select 25 tasks from an initial set of 296 in the Bionic Vision Australia retinal prosthesis project. The tasks were performed by 40 participants with very low vision (VLV) and scored for speed and accuracy.…”

Section: Specific Ulv Adl Test Methodologiesmentioning

confidence: 99%

“… Examples of activity of daily living tasks that could be used in vision restoration trial, from the IADL-VLV 98 ; ( left ) sorting socks and ( right ) kitchen object identification. …”

Section: Visual Acuitymentioning

confidence: 99%

Harmonization of Outcomes and Vision Endpoints in Vision Restoration Trials: Recommendations from the International HOVER Taskforce

Ayton

Rizzo

Bailey

et al. 2020

Trans. Vis. Sci. Tech.

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Developing an Instrumental Activities of Daily Living Tool as Part of the Low Vision Assessment of Daily Activities Protocol

Abstract: Using a large item pool, participant, and expert input, as well as factor and Rasch analysis, we designed a valid and reliable assessment to measure vision-related IADL performance in persons with severe vision loss. This assessment tool can be used in clinical sight restoration trials.

Cited by 33 publications

References 44 publications

Assessment of the Electronic Retinal Implant Alpha AMS in Restoring Vision to Blind Patients with End-Stage Retinitis Pigmentosa

Assessment of the Electronic Retinal Implant Alpha AMS in Restoring Vision to Blind Patients with End-Stage Retinitis Pigmentosa

Calibrating the Impact of Vision Impairment (IVI): Creation of a Sample-Independent Visual Function Measure for Patient-Centered Outcomes Research

Harmonization of Outcomes and Vision Endpoints in Vision Restoration Trials: Recommendations from the International HOVER Taskforce

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