Developing neurons are innately inclined to learn on the job

The corpus callosum (CC) connects the cerebral hemispheres and is the major mammalian commissural tract. It facilitates bilateral sensory integration and higher cognitive functions, and is often affected in neurodevelopmental diseases. Here, we review the mechanisms that contribute to the development of CC circuits in animal models and humans. These species comparisons reveal several commonalities. First, there is an early period of massive axonal projection. Second, there is a postnatal temporal window, varying between species, in which early callosal projections are selectively refined. Third, sensory-derived activity influences axonal refinement. We also discuss how defects in CC formation can lead to mild or severe CC congenital malformations.

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Origin, Development, and Synaptogenesis of Cortical Interneurons

Llorca

Deogracias

2022

Front. Neurosci.

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The mammalian cerebral cortex represents one of the most recent and astonishing inventions of nature, responsible of a large diversity of functions that range from sensory processing to high-order cognitive abilities, such as logical reasoning or language. Decades of dedicated study have contributed to our current understanding of this structure, both at structural and functional levels. A key feature of the neocortex is its outstanding richness in cell diversity, composed by multiple types of long-range projecting neurons and locally connecting interneurons. In this review, we will describe the great diversity of interneurons that constitute local neocortical circuits and summarize the mechanisms underlying their development and their assembly into functional networks.

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Developing neurons are innately inclined to learn on the job

Cited by 3 publications

References 11 publications

Genetic and activity dependent-mechanisms wiring the cortex: Two sides of the same coin

Genetic and activity dependent-mechanisms wiring the cortex: Two sides of the same coin

Development and plasticity of the corpus callosum

Origin, Development, and Synaptogenesis of Cortical Interneurons

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