Developing New Strategies for the Treatment of Tuberculosis Employing Ruthnium(II)Quaterpyridyl Compexes

Abstract

A series of ruthenium (II)

Photophysical Investigatigation of Poly [N-isopropylacrylamide-co-Acrylic Acid] Copolymers

“…The basic concept is to incorporate a molecule with selected photophysical properties into the system. This probe molecule, via its spectroscopic properties, reports back on the nature of its environment, and on the access of other quencher molecules, from various regions of the system, to the probe molecule 11,12 . Photophysical probe ruthenium(II)-tris(phenanthroline) has been used in this study to monitor the conformational change (size contraction) and to investigate the LCST behaviour of poly [NIPAM] and its copolymers featuring pH sensitive group.…”

“…An interesting feature common to other thermosensitive polymers lies in the possibility of tuning the LCST by adding cosolvents, salts, surfactants or polyelectrolytes to the PNIPAM solutions or by incorporating comonomers with variable degree of hydrophilicity, in fact increasing or decreasing the hydrophilic content of a copolymer will usually result in an increase or decrease, respectively, of its LCST. Furthermore, polymerizing N-isopropylacrylamide (NIPAM) with weakly ionisable comonomers permit to obtain stimulie responsive polymers capable of responding to both temperature and pH variations; interestingly, owing to the variation of their degree of ionization with pH, systems with pH dependent LCST are obtained 5,6,7 . The general application of fluorescence as a probe to characterize the polarity, mobility, and other properties in diverse media has been already described in many literatures.…”

Nanoscopic surfactant behavior of the porin MspA in aqueous media

“…Moreover, this protein can stand alone on surfaces without a supporting polymer or double layer [6]. It is capable of binding gold nanoparticles [6–7] and Ruthenium(II) polypyridyl complexes [8]. In fact, the binding of so-called “channel blockers” near the constriction zone of MspA has been discussed as a new strategy to fight mycobacterial infections, such as tuberculosis [8–9].…”

“…It is capable of binding gold nanoparticles [6–7] and Ruthenium(II) polypyridyl complexes [8]. In fact, the binding of so-called “channel blockers” near the constriction zone of MspA has been discussed as a new strategy to fight mycobacterial infections, such as tuberculosis [8–9]. Although the presence of MspA homo-octamers on surfaces has been unambiguously proven by using transmission electron microscopy (TEM) [5], atomic force microscopy (AFM) [6], and electrochemical techniques [10], only very little is known about the three-dimensional clustering behavior of MspA in aqueous phase.…”

Synthesis and Characterization of Poly(NIPAM-co-AA) Polymers Possessing Perfluorinated Side Chains and Chemically Linked Pyrene Labels

“…Consequently, the physical properties of these model systems permit their straight-forward applications in systems of technical importance in a straight forward manner. In the work reported here, we introduced chemically linked perfluorinated side chains as a profound example of a hydrophobic function in the water soluble Poly (NIPAM -co-AA) polymer 3 .…”