Developing oral nanovaccines for fish: a modern trend to fight infectious diseases

Angulo, Carlos; Tello‐Olea, Marlene; Reyes‐Becerril, Martha; Monreal‐Escalante, Elizabeth; Hernández‐Adame, Luis; Angulo, Miriam; Mazón‐Suástegui, José Manuel

doi:10.1111/raq.12518

Cited by 28 publications

(27 citation statements)

References 151 publications

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“…A recent study reported the use of various organic materials like PLGA, nanopoliplexes, chitosan, and virus-like particles (VLPs) for developing nanovaccines to control pathogenic fish diseases. They showed that oral nanovaccines can be used in fish aquaculture (Angulo et al 2020 ). Another recent study reported that selenium nanoparticles have proven to be a novel tool for controlling various bacterial as well as viral fish diseases (Nasr-Eldahan et al 2021 ).…”

Section: Types Of Vaccines For Fish Pathogens In Aquaculture and Thei...mentioning

confidence: 99%

A review on the recent advances and application of vaccines against fish pathogens in aquaculture

2022

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Globally, aquaculture has faced serious economic problems due to bacterial, viral, and various other infectious diseases of different origins. Even though such diseases are being detected and simultaneously treated with several therapeutic and prophylactic methods, the broad-spectrum activity of vaccines plays a vital role as a preventive measure in aquaculture. However, treatments like use of antibiotics and probiotics seem to be less effective when new mutant strains develop and disease causing pathogens become resistant to commonly used antibiotics. Therefore, vaccines developed by using recent advanced molecular techniques can be considered as an effective way of treating disease causing pathogens in aquatic organisms. The present review emphasizes on the current advances in technology and future outlook with reference to different types of vaccines used in the aquaculture industries. Beginning with traditional killed/inactivated and live attenuated vaccines, this work culminates in the review of modern new generation ones including recombinant, synthetic peptides, mucosal and DNA, subunit, nanoparticle-based and plant-based edible vaccines, reverse vaccinology, and monovalent and polyvalent vaccines.

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Section: Types Of Vaccines For Fish Pathogens In Aquaculture and Thei...mentioning

confidence: 99%

A review on the recent advances and application of vaccines against fish pathogens in aquaculture

2022

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“…TCEs from tetanus toxin and measles virus are known to increase the immunogenicity in salmonid immune system (Leal et al, 2019;Contreras et al, 2020;Swain et al, 2020). Moreover, technologies, such as adjuvants and nanoparticles, in combination with conventional approaches for enhanced immunogenicity are additional perspectives for the future (Dadar et al, 2017;Angulo et al, 2020).…”

Section: Vaccinesmentioning

confidence: 99%

“…Only injectable vaccines have provided positive results, but they are far from optimal. While protection is generally high, application is labor-intensive and stressful for the fish (Angulo et al, 2020). However, with the introduction of highthroughput injectable devices capable of injecting thousands of fishes under anesthesia every hour, application time has been greatly reduced.…”

Section: Vaccinesmentioning

confidence: 99%

Principles and Methods of Counteracting Harmful Salmon–Arthropod Interactions in Salmon Farming: Addressing Possibilities, Limitations, and Future Options

et al. 2021

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The arthropod salmon louse (Lepeophtheirus salmonis) is a major threat to Atlantic salmon aquaculture and wild salmonids. Essentially like in monoculture, very high concentrations of susceptible hosts may result in high reproduction and severe production of waves of pests. Pest management is crucial both for fish health and protection of wild fish populations from aquaculture influence. Various methods have been utilized to control salmon lice infestations, such as pesticide use, physical treatments, construction modifications, fallowing, breeding, vaccination, and biological control. Most of the methods are partially successful, but none completely fulfills the necessary pest control strategy. Like in agriculture, lice/pest management is an arms race, but the marine environment makes it even more difficult to precisely hit the target pest and avoid unintended negative effects on general wildlife. In this study, we provide an overview of the methods and principles of salmon lice management and address current possibilities and limitations. We also highlight the potential of emerging strategies and enabling technologies, like genome editing, RNA interference, and machine learning, in arthropod management in aquaculture.

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“…This result may be explained with changes in nanoparticles between dilutions (higher dilutions associated to smaller nanoparticle size). Nanoparticles have different affinity within cell receptors and different physical properties, such as charge, size and shape 12,18,19,39 and surface chemistry as the nanoparticle‐protein corona 30 …”

Section: Highly Diluted Bioactive Compounds Preparationsmentioning

confidence: 99%

“…Immunostimulants can be formulated from bacteria‐derived compounds, such as toxins, unmethylated CpG DNA sequences, β‐glucans and lipopolysaccharides 72,74‐76 . Moreover, they can be obtained from nutritional factors, such as prebiotics and carotenes, 77 hormones/cytokines, 71,73,78 plant extracts 73 and nanoparticles 29,30 …”

Section: Hdbc and Their Use In Aquaculture As Immunostimulants And Ge...mentioning

confidence: 99%

Highly diluted bioactive compounds in marine aquaculture: A potential alternative for sustainable production

López‐Carvallo¹,

Mazón‐Suástegui²,

Arcos-Ortega³

et al. 2021

Reviews in Aquaculture

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Highly diluted bioactive compounds (HDBC) and highly diluted immunomodulatory compounds (HDIC) are treatments that cover a wide variety of concentrations, starting from molar to yoctomolar concentrations or even lower where the presence of nanoparticles has been detected. The prophylactic use of these compounds has improved nutrition, growth, overall condition, defence mechanisms regulation and increased marine organism survival during challenge against pathogens. The HDBC used in marine organisms are formulated from Vibrio spp. lysates, sodium metasilicates, phosphoric acid and highly diluted drugs for humans as Silicea terra®, Phosphoricum acidum®, Passival® and VidatoX®, as well as homotoxic Heel® complexes. Because HDBC are innocuous, inexpensive and easy to use by immersion or ingestion, they have been proposed as a potential sustainable alternative to improve marine organism production under hatchery conditions and reduce the use of chemotherapy, including antibiotics and disinfectants. Nonetheless, articles documenting their mode of action (biological process and metabolic pathways activated) are scarce. Some studies have proposed that certain HDBC activate the sentinel system of marine organisms, such as non‐self‐recognition and endocytosis mechanisms without completely activating the immune defence mechanisms. This contribution brings a new insight on increasing productivity and cost effectiveness during hatchery operations and at the same time strengthening the immune system response and survival of marine organisms against infections. Therefore, this review discusses and analyses published results of HDBC in species of commercial importance worldwide and also emerging species of interest for aquaculture reared in Mexico.

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Developing oral nanovaccines for fish: a modern trend to fight infectious diseases

Cited by 28 publications

References 151 publications

A review on the recent advances and application of vaccines against fish pathogens in aquaculture

A review on the recent advances and application of vaccines against fish pathogens in aquaculture

Principles and Methods of Counteracting Harmful Salmon–Arthropod Interactions in Salmon Farming: Addressing Possibilities, Limitations, and Future Options

Highly diluted bioactive compounds in marine aquaculture: A potential alternative for sustainable production

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