Developing Useful Highly Active Antiretroviral Therapy Adherence Measures for India: The Prerana Study

Chandy, Sara; Heylen, Elsa; Steward, Wayne T.; Singh, Girija

doi:10.1097/qai.0b013e3181ba3e4e

Cited by 45 publications

(47 citation statements)

References 15 publications

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“…Our study results correlate with other similar studies. [12][13][14] This high percentage of adherence might be due to regular follow up by patients and adherence counselling done at each follow up visit thereby enabling patients to adhere better.…”

Section: Discussionmentioning

confidence: 99%

Adherence to antiretroviral therapy and factors affecting adherence among paediatric HIV patients

Govind

Gabhale

Shah

et al. 2017

Int J Contemp Pediatr

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Background: Adherence to antiretroviral therapy (ART) is the strongest indicator of successful treatment of Human Immunodeficiency Virus (HIV) among children. The main aim of the present study was to know the prevalence of adherence at our centre and various factors affecting the adherence in children.Methods: It was an observational study done in children less than 15 years of age, affected with HIV. 78 children attending Paediatric Centre of Excellence (PCOE) for HIV L.T.M.G. Hospital, Sion, Mumbai were included in study, Study period was 18 months from January 2012 to June 2013. Complete history of the patients was noted in a pre-designed proforma. Baseline investigations related to HIV were done in all children. Fixed dose combination ART was started in children who fulfilled clinical and/or immunological criteria as per the NACO guidelines. Adherence was estimated using Pill count method..All the data were analysed by using 10.0 version of statistical software SPSS.Results: In this study, male children (57.7%) out numbered the females (42.3%). Majority of study subjects were more than 10 years of age. Overall adherence among subjects was 82.1% at the end of one year and non-adherence was 17.9%. There was no significant association of age and gender of the patients with adherence (p>0.05). Education, employment and knowledge towards medication of care takers was significantly associated with adherence of ART (p<0.05). Adherence of study cases had not showed any significant association with ART treatment regimen (p=0.99). At the end of one year, the mean CD4 count was significantly more as compared to baseline among adherence group and the mean CD4 count was significantly less as compared to baseline among non-adherence group. The most common reason for missed dosage was forgot to take medicine in 29 subjects (37.1 %)..Conclusion: Adherence level in this study was good. Forgot to take the medicine was the main reason given by the patients for non-adherence. Education, employment and knowledge towards medication of care takers was significantly associated with adherence of ART .But further studies are needed to explore various other factors related to adherence in children.

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Section: Discussionmentioning

confidence: 99%

Adherence to antiretroviral therapy and factors affecting adherence among paediatric HIV patients

Govind

Gabhale

Shah

et al. 2017

Int J Contemp Pediatr

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show abstract

“…[23] Items were rated using a Likert scale of strongly agree to strongly disagree. In addition, participants completed an assessment of their relationship with their health care provider(s) [24] which consisted of 10 questions regarding the frequency and satisfaction with provider communication and action related to treatment, rated on a Likert scale of ‘never’ to ‘all the time’ (subscale α ranged from .71–.86 in this sample). HIV-specific health literacy was assessed using a measure previously developed [25] adapted by the team for local accuracy, and assessed participant knowledge of their current CD4 and VL count and understanding of the meaning of both tests.…”

Section: Methodsmentioning

confidence: 99%

Examining Adherence Among Challenging Patients in Public and Private HIV Care in Argentina

et al. 2015

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Treatment engagement, retention and adherence to care are required for optimal HIV outcomes. Yet, patients may fall below the treatment recommendations for achieving undetectable viral load or not be retained in care. This study examined the most challenging patients in Buenos Aires, Argentina, those non-adherent to HIV care. Men (n = 61) and women (n = 59) prescribed antiretrovirals (ARVs) and non-adherent to treatment in the prior 3 to 6 months were enrolled and assessed regarding adherence, knowledge, motivation and attitudes regarding treatment. Private clinic patients had lower viral load and higher self-reported adherence than public clinic patients. Motivations to be adherent and positive beliefs regarding ARVs were associated with increased adherence in public clinic participants. Increased self-efficacy was associated with increased adherence among participants from both clinics. Results support patient and provider interventions that strengthen the characteristics supporting adherence, engagement and retention in public and private clinic settings. Resumen El compromiso, la retención en el cuidado y adherencia al tratamiento son esenciales para el manejo óptimo del paciente con VIH. Sin embargo, muchos pacientes con VIH no siguen las el tratamiento para lograr tener una carga viral indetectable, o no permanecen bajo cuidado médico. Este estudio examina los pacientes más difíciles de retener en el cuidado médico en Buenos Aires, Argentina. Hombres (n = 61) y mujeres (n = 59) a los que se les habían recetado antiretrovirales pero seguían el tratamiento en los últimos 3 - 6 meses participaron en el estudio. Adherencia, conocimiento, motivación y actitudes frente al tratamiento fueron evaluados. Los pacientes en la clínica privada tenían menor carga viral y mejor adherencia que los de la clínica pública. Motivación y pensamientos positivos con respecto a antiretrovirales estaban asociados con mejor adherencia en los pacientes de la clínica pública. La autoeficacia estaba asociada con mejor adherencia en los pacientes en las dos clínicas. Los resultados indican que son necesarias intervenciones en pacientes y médicos para mejorar adherencia, compromiso y retención en el cuidado tanto en clínicas públicas como privadas.

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“…(18) It has also been used in many regions in India. (19)(20)(21) HAART-related profiles of the patients were taken from ART cards and medical records. Data regarding sociodemographic characteristics and adherence to HAART were collected using in-depth interviews.…”

Section: E Th O Dsmentioning

confidence: 99%

Adherence to highly active antiretroviral therapy in a tertiary care hospital in West Bengal, India

Saha

Saha²,

Sarkar³

et al. 2014

smedj

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Developing Useful Highly Active Antiretroviral Therapy Adherence Measures for India: The Prerana Study

Cited by 45 publications

References 15 publications

Adherence to antiretroviral therapy and factors affecting adherence among paediatric HIV patients

Adherence to antiretroviral therapy and factors affecting adherence among paediatric HIV patients

Examining Adherence Among Challenging Patients in Public and Private HIV Care in Argentina

Adherence to highly active antiretroviral therapy in a tertiary care hospital in West Bengal, India

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