Development and application of a specially designed heating system for temperature-programmed high-performance liquid chromatography using subcritical water as the mobile phase

Teutenberg, Thorsten; Goetze, H.-J.; Tuerk, Jochen; Ploeger, J.; Kiffmeyer, Thekla K.; Schmidt, K. G.; Kohorst, W. gr.; Rohe, T.; Jansen, H.; Weber, H.

doi:10.1016/j.chroma.2006.02.041

Cited by 56 publications

(32 citation statements)

References 28 publications

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“…Fields et al [58] described the use of superheated water on polybutadiene-coated zirconia for the analysis of testosterone related compounds with comparable efficiencies to conventional RPLC and different chromatographic selectivities. Coym and Dorsey [59] and Teutenberg et al [60,61] have also discussed the design of HTLC systems capable of thermal gradients and the use and properties of pure water as a mobile phase . Thermally stable column-packing materials have enabled a new approach to stable analytical separations at very high temperatures.…”

Section: "Green" Htlcmentioning

confidence: 99%

Practice and theory of high temperature liquid chromatography

McNeff¹,

Yan

Stoll

et al. 2007

J of Separation Science

115

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Review Practice and theory of high temperature liquid chromatographyHigh temperature liquid chromatography (HTLC) exists in a temperature region beyond ambient (ca. 408C) and below super critical temperatures. The promises of HTLC, such as increased analysis speed, enhanced separation productivity, "green" LC with pure water mobile phases coupled to universal FID detection, and fast analysis of complex samples by combination with fast 2-D techniques, have become an option for routine practice. The focus of this paper is to review the key developments that have made the application of HTLC a practical technique and draw attention to new developments in 2-D techniques that incorporate HTLC that offer an opportunity to vastly increase the usefulness of HPLC for the analysis of complex samples.

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Section: "Green" Htlcmentioning

confidence: 99%

Practice and theory of high temperature liquid chromatography

McNeff¹,

Yan

Stoll

et al. 2007

J of Separation Science

115

View full text Add to dashboard Cite

show abstract

“…A number of classes of organic compounds have been separated by SBWC. They include carbohydrates [15][16][17][18], amino acids [15,17,18], alcohols [11,[19][20][21][22][23][24], carboxylic acids [8,15], phenols [8-11, 18, 24-30], anilines [9,18,30], phosphonic acids [17], PTH-amino acids [31][32][33], aldehydes [34], water-soluble vitamins [35], caffeine derivatives [11,14,27,36,37], parabens [10,26,37], barbiturates [10,26,38], steroids [33,[39][40][41][42], model drugs [43][44][45][46], sulfonamides [47,48], flavones [49], triazole fungicides …”

Section: Introductionmentioning

confidence: 99%

Subcritical water chromatography: A green approach to high‐temperature liquid chromatography

Yang¹

2007

J of Separation Science

104

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At temperatures and pressures lower than 374 degrees C and 218 atm, subcritical water has widely tunable properties such as dielectric constant, surface tension, viscosity, and dissociation constant achieved by simply adjusting the temperature with a moderate pressure to keep water in the liquid state. At elevated temperatures, water acts like a weak polar organic solvent. Thus, subcritical water has been used as a green eluent to replace hazardous solvents commonly used as organic modifiers in RPLC. Subcritical water chromatography (SBWC) is capable of separating polar, moderately polar, and even some nonpolar analytes. Most of these low molecular weight solutes are stable at elevated temperatures during a chromatographic run. Some new packing materials are also quite stable and robust at mild temperatures ranging from 80 to 150 degrees C. Advantages of SBWC include the elimination of hazardous organic solvents used in traditional RPLC, rapid analysis time, improved selectivity, temperature-dependent separation efficiency, temperature-programmed elution, and compatibility with both gas- and liquid-phase detectors. In this paper, the technical aspects as well as the applications of SBWC are reviewed. Topics addressed in this review include the unique characteristics of subcritical water, analytes separated by SBWC, packing materials tested for SBWC, the application of GC and LC detection techniques in SBWC, SBWC instrumentation development, temperature effects on SBWC separation, and models developed for separation in SBWC.

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“…29 To avoid this, either an extended preheating coil in the hot air oven or a heater on the inlet line is generally used in SWC systems. Although the former is not superior to a rapid heat transfer system, 23 it is easier to operate. Thus, in this study, a preheating coil was placed in the column oven.…”

Section: Optimization Of Length Of the Preheating Coilmentioning

confidence: 99%

“…20 However, few published studies to date have demonstrated high-speed separation using this method. [20][21][22][23] One of the major constraints on the development of SWC has been the poor stability of many stationary phases. The octadecylsilyl-silica gel (ODS) stationary phase, which is widely used in conventional RP-HPLC under ambient conditions, was A superheated water chromatography (SWC) method for the separation of alkyl esters of 4-hydroxybenzoic acid (parabens) using a zirconia-based stationary phase was developed and applied to real sample analysis.…”

Section: Introductionmentioning

confidence: 99%