Development and application of high-performance liquid chromatography for the study of two new oxyprenylated anthraquinones produced by Rhamnus species

Locatelli, Marcello; Genovese, Salvatore; Carlucci, Giuseppe; Kremer, Dario; Randić, Marko; Epifano, Francesco

doi:10.1016/j.chroma.2011.12.085

Cited by 43 publications

(26 citation statements)

References 35 publications

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“…Free anthraquinones and phenolics HPLC-PDA chemical fingerprint HPLC-PDA anthraquinones multicomponent pattern was evaluated by method reported in literature 3,25 . HPLC-PDA phenolics multicomponent pattern was performed on a Waters liquid chromatograph equipped with a model 600 solvent pump and a 2996 photodiode array detector, and Empower v.2 Software (Waters Spa, Milford, MA) was used for the acquisition of data.…”

Section: Total Phenolics and Total Flavonoids Contentmentioning

confidence: 99%

“…Anthraquinones are well known for their biological activities on different targets and the analytical procedures able to their qualiquantitative analyses are recently reviewed 2 or described 3 . Furthermore, phenolic compounds have recently received particular attention owing to their possible preventive role in neurological disorders [4][5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

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Comparative study of biological activities and multicomponent pattern of two wild Turkish species: Asphodeline anatolica and Potentilla speciosa

Zengin

Menghini

Malatesta

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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The multicomponent pattern and biological characterization of plant material are essential for pharmaceutical field, in the food supplements quality control procedures and to all plant-based products. These nutrients often show valuable effects related to their consumption due to the occurrence of secondary metabolites that show useful properties on health. In this framework, researches performed on this topic play a central role for human health and drug development process. The aim of this study was to compare phenolics and free anthraquinones multicomponent pattern of two wild Turkish species: Asphodeline anatolica and Potentilla speciosa using validated high-performance liquid chromatography-photogiode array (HPLC-PDA) assays, coupled to biological evaluation. Even if some variances related to biological and enzymatic inhibition activities can be ascribed to other phytochemicals, the reported data support traditional use of Asphodeline anatolica and Potentilla speciosa roots as valuable natural font for the development of novel natural-derived drug formulations and/or food supplements with health and nutritional benefits.

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Section: Total Phenolics and Total Flavonoids Contentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative study of biological activities and multicomponent pattern of two wild Turkish species: Asphodeline anatolica and Potentilla speciosa

Zengin

Menghini

Malatesta

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Anthraquinones are a group of phenolics and are widely distributed in many plant families such as Fabaceae, Liliaceae, Rubiaceae and Rhamnaceae 12 . Anthraquinones derivatives such as emodine, physcione, rhein and chrysophanol have been used as colorants in food, drugs and cosmetics.…”

Section: Introductionmentioning

confidence: 99%

Anthraquinone profile, antioxidant and enzyme inhibitory effect of root extracts of eightAsphodelinetaxa from Turkey: canAsphodelineroots be considered as a new source of natural compounds?

Zengin

Locatelli

Ceylan

2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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Plant-based foods have become attractive for scientists and food producers. Beneficial effects related to their consumption as dietary supplements are due to the presence of natural occurring secondary metabolites. In this context, studies on these products are important for natural and safely food ingredients evaluation. The aim of this study was to evaluate root extract of eight Asphodeline species as antioxidants, enzyme inhibitors and phytochemical content. Spectrophotometric antioxidant and enzyme inhibitory assays were performed. Total phenolic and flavonoids contents as well as the chemical free-anthraquinones profiles were determined using routinely procedure (HPLC-PDA). Data show that Asphodeline roots can be considered as a new source of natural compounds and can be used as a valuable dietary supplement. Some differences related to biological activities can be inferred to other phytochemicals that can be considered in the future for their synergic or competitive activities.

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“…Anthraquinone glycosides including emodin, physcion, aloe-emodin, rhein, and chrysophanol are nowadays well recognized as important biologically active components ( Figure 2 ) [ 8 ]. Recently, it was reported that anthraquinones exert a wide range of biological activities including antifungal, antimicrobial, and anticancer properties other than the well-known laxative action on the gastrointestinal apparatus [ 9 – 11 ]. Besides health benefits of anthraquinones, it was also reported that they have a cell toxicity effect.…”

Section: Discussionmentioning

confidence: 99%

Toxic Effects ofRhamnus alaternus: A Rare Case Report

Ghezala¹,

Chaouali²,

Gana³

et al. 2015

Case Reports in Emergency Medicine

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In Tunisia, there are about 478 species of plants commonly used in folk medicine. Medicinal plants and herbal remedies used are responsible for 2% of intoxications listed by Tunisian National Poison Center. Most cases are related to confusion between edible plants and toxic plants lookalikes or to an excessive consumption of therapeutic plants. We report the case of a 58-year-old man admitted to the Emergency Department of the Regional Hospital of Zaghouan (Tunisia), with renal failure and rhabdomyolysis. The patient reported having daily consumption of a homemade tea based on Mediterranean Buckthorn roots, during the last 6 months to treat type 2 diabetes. The aim of this work was to establish an association between the consumption of the herbal remedy and the occurrence of both renal failure and rhabdomyolysis. No similar cases have been reported in recent literature.

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Development and application of high-performance liquid chromatography for the study of two new oxyprenylated anthraquinones produced by Rhamnus species

Cited by 43 publications

References 35 publications

Comparative study of biological activities and multicomponent pattern of two wild Turkish species: Asphodeline anatolica and Potentilla speciosa

Comparative study of biological activities and multicomponent pattern of two wild Turkish species: Asphodeline anatolica and Potentilla speciosa

Anthraquinone profile, antioxidant and enzyme inhibitory effect of root extracts of eightAsphodelinetaxa from Turkey: canAsphodelineroots be considered as a new source of natural compounds?

Toxic Effects ofRhamnus alaternus: A Rare Case Report

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