Development and characterization of a novel conductive polyaniline-g-polystyrene/Fe ₃ O ₄ nanocomposite for the treatment of cancer

Abstract

The goal of this study is to synthesize, characterize and investigate some physicochemical properties of conductive polyaniline-g-polystyrene/Fe 3 O 4 (Fe 3 O 4 /PSt-g-PANi) nanocomposites. For this purpose, initially, Fe 3 O 4 nanoparticles were synthesized by a co-precipitation method. Then, the desired nanocomposite was synthesized in two steps. First, the atom transfer radical polymerization (ATRP) of styrene was performed using an ATRP initiator attached to the surface of Fe 3 O 4 nanoparticles, followed by functionalization of the Fe 3 O 4-PSt with amine groups (-NH 2). Second, surface oxidative graft copolymerization of aniline was accomplished using the-NH 2 moieties on the Fe 3 O 4 /PSt-NH 2 as the anchoring sites. The prepared materials were characterized by various instruments, including TEM, SEM, TGA, EDX, FT-IR, XRD and conductivity measurements. The results indicated that the synthesized conductive polymer/Fe 3 O 4 nanocomposites had higher electrical conductivity and thermal resistance than those of the corresponding homopolymers.

Advances in Polyaniline for Biomedical Applications

“…For most applications PANI nanocomposites and PANI blends are more suitable than pristine polymer. In fact, they combine the peculiar features of PANI, such as lightness, conductivity, redox activity, etc., with those of the filler (e.g., magnetic [84,85], photoactive [86,87], photothermal [88][89][90][91] luminescent [90,92] properties and so on). The paragraphs 3.1.8. and 3.1.9. are dedicated to innovative syntheses of PANI in form of nanocomposites and blends.…”

“…Fe3O4 NPs are the most employed magnetic components in these materials owing to their ease of synthesis, high stability and size and shape tunability. Fe3O4/PANI nanohybrids exploit all these aspects and were studied for MR imaging and redox sensing of the cancer cell microenvironment [84]. The synthetic procedure of magnetic PANI nanohybrids is reported in Figure 12.…”

Electroconductive Nanobiomaterials for Tissue Engineering and Regenerative Medicine

“…Among conductive polymers, polyaniline (PANI), poly(3,4-ethylenedioxythiophene) (PEDOT), and polypyrrole (PPy) are the most extensively studied. 40 Detailed information about the conductivity values of these polymers, along with their other physicochemical properties, can be found elsewhere. 41 One major problem Overview of the concept of using a suture-free technology for the attachment of an engineered cardiac patch to the organ.…”

Recent achievements in nano-based technologies for ocular disease diagnosis and treatment, review and update

“…Certain nanoscale materials show exceptional mechanical, electrical, optical, magnetic, and chemical characteristics. These properties can be utilized to improve the physicochemical and biological characteristics of drugs and drug delivery systems [ 12 – 14 ]. The application of nanotechnology in the diagnosis and treatment of ocular disorders has also made rapid progress (Fig.…”