Development and Characterization of Bioactive Glass Containing Composite Coatings with Ion Releasing Function for Antibiotic-Free Antibacterial Surgical Sutures

Ciraldo, Francesca E.; Schnepf, Kristin; Goldmann, Wolfgang H.; Boccaccını, Aldo R.

doi:10.3390/ma12030423

Cited by 26 publications

(18 citation statements)

References 33 publications

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“…For example, multidrug-resistant (MDR) phenotypes of S. aureus and P. aeruginosa have been identified, causing infectious wounds [ 153 , 154 ]. In this regard, the use of metallic antibacterial elements (e.g., Ag) is suggested as an appropriate alternative for inhibiting MDR bacteria [ 155 , 156 , 157 , 158 , 159 ]. As one of the most well-known antibacterial agents, Ag has been using for inhibiting and killing a broad range of bacterial species [ 160 ].…”

Section: Mbgs For Skin Cancer Therapymentioning

confidence: 99%

Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

et al. 2021

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Exploring new therapies for managing skin wounds is under progress and, in this regard, mesoporous silica nanoparticles (MSNs) and mesoporous bioactive glasses (MBGs) offer great opportunities in treating acute, chronic, and malignant wounds. In general, therapeutic effectiveness of both MSNs and MBGs in different formulations (fine powder, fibers, composites etc.) has been proved over all the four stages of normal wound healing including hemostasis, inflammation, proliferation, and remodeling. The main merits of these porous substances can be summarized as their excellent biocompatibility and the ability of loading and delivering a wide range of both hydrophobic and hydrophilic bioactive molecules and chemicals. In addition, doping with inorganic elements (e.g., Cu, Ga, and Ta) into MSNs and MBGs structure is a feasible and practical approach to prepare customized materials for improved skin regeneration. Nowadays, MSNs and MBGs could be utilized in the concept of targeted therapy of skin malignancies (e.g., melanoma) by grafting of specific ligands. Since potential effects of various parameters including the chemical composition, particle size/morphology, textural properties, and surface chemistry should be comprehensively determined via cellular in vitro and in vivo assays, it seems still too early to draw a conclusion on ultimate efficacy of MSNs and MBGs in skin regeneration. In this regard, there are some concerns over the final fate of MSNs and MBGs in the wound site plus optimal dosages for achieving the best outcomes that deserve careful investigation in the future.

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Section: Mbgs For Skin Cancer Therapymentioning

confidence: 99%

Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

et al. 2021

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“…TiO 2 films with crystalline phases (anatase and a mixture of anatase and rutile) can produce higher amounts of ROS and biofilm reduction (composed of Streptococcus sanguinis, Actinomyces naeslundii, and Fusobacterium nucleatum) after the UV light activation compared to pure rutile TiO 2 films [ 39 ]. Among metallic nanomaterials, silver nanomaterials are one of the well-known anti-infective agents used for wound dressing, but their resistance to silver is an emerging issue impairing the wound-healing process [ 222 , 223 ]. Hence, a composition of TiO 2 nanomaterials and antimicrobial polymers can improve the wound-healing process, because the antimicrobial activity of TiO 2 nanomaterials under UV light irradiation can be harnessed against heavy-metal-resistant bacteria.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Insights into Theranostic Properties of Titanium Dioxide for Nanomedicine

Kafshgari

Goldmann

2020

Nano-Micro Lett.

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HIGHLIGHTS • Multifunctional TiO 2 nanostructures hold promise for advancing a wide range of biomedical applications due to a feasible integration of distinct theranostic features. • Fabrication and post-fabrication strategies implemented to generate multifunctional TiO 2 nanostructures for a broad range of biomedical applications are briefly outlined. The opportunities and challenges of TiO 2 nanomaterials are highlighted in order to open the possibility of clinical translation. ABSTRACT Titanium dioxide (TiO 2 ) nanostructures exhibit a broad range of theranostic properties that make them attractive for biomedical applications. TiO 2 nanostructures promise to improve current theranostic strategies by leveraging the enhanced quantum confinement, thermal conversion, specific surface area, and surface activity. This review highlights certain important aspects of fabrication strategies, which are employed to generate multifunctional TiO 2 nanostructures, while outlining post-fabrication techniques with anemphasis on their suitability for nanomedicine. The biodistribution, toxicity, biocompatibility, cellular adhesion, and endocytosis of these nanostructures, when exposed to biological microenvironments, are examined in regard to their geometry, size, and surface chemistry. The final section focuses on recent biomedical applications of TiO 2 nanostructures, specifically evaluating therapeutic delivery, photodynamic and sonodynamic therapy, bioimaging, biosensing, tissue regeneration, as well as chronic wound healing.

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“…To improve antibacterial functionality, CS films are usually deposited as composites, combining chitosan with inorganic and metallic particles [ 2 , 14 , 15 , 16 , 17 , 18 ]. The best antibacterial performance has been achieved for the CS–silver nanoparticle (AgNP) composites [ 16 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Anodic Electrodeposition of Chitosan–AgNP Composites Using In Situ Coordination with Copper Ions

et al. 2021

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Chitosan is an attractive material for biomedical applications. A novel approach for the anodic electrodeposition of chitosan–AgNP composites using in situ coordination with copper ions is proposed in this work. The surface and cross-section morphology of the obtained coating with varying concentrations of AgNPs were evaluated by SEM, and surface functional groups were analyzed with FT-IR spectroscopy. The mechanism of the formation of the coating based on the chelation of Cu(II) ions with chitosan was discussed. The antibacterial activity of the coatings towards Staphylococcus epidermidis ATCC 35984/RP62A bacteria was analyzed using the live–dead approach. The presented results indicate that the obtained chitosan–AgNP-based films possess some limited anti-biofilm-forming properties and exhibit moderate antibacterial efficiency at high AgNP loads.

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Development and Characterization of Bioactive Glass Containing Composite Coatings with Ion Releasing Function for Antibiotic-Free Antibacterial Surgical Sutures

Cited by 26 publications

References 33 publications

Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

Insights into Theranostic Properties of Titanium Dioxide for Nanomedicine

Anodic Electrodeposition of Chitosan–AgNP Composites Using In Situ Coordination with Copper Ions

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