Development and characterization of chitosan-based hydrogels as wound dressing materials

Mukherjee, Dhrubojyoti; Azamthulla,; Santhosh, Shivalingappa; Dath, Guru; Ghosh, Arijit; Natholia, Rahul; Anbu, J.; Banala, Venkatesh Teja; Muzammil, K. Mohammed

doi:10.1016/j.jddst.2018.06.008

Cited by 66 publications

(30 citation statements)

References 51 publications

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“…Mukherjee et al [38] developed hydrogel dressings with interpolymeric complexation method to enhance wound healing activity in excision wound model. CS was cross-linked with polyvinyl alcohol, sodium alginate and Pluronic F68 at different ratios.…”

Section: Biomaterials For Wound Managementmentioning

confidence: 99%

Recent trends on wound management: New therapeutic choices based on polymeric carriers

Okur

Karantas

Şenyiğit

et al. 2020

Asian Journal of Pharmaceutical Sciences

227

115

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Wound healing is an unmet therapeutic challenge among medical society since wound assessment and management is a complex procedure including several factors playing major role in healing process. Wounds can mainly be categorized as acute or chronic. It is well referred that the acute wound displays normal wound physiology while healing, in most cases, is seemed to progress through the normal phases of wound healing. On the other hand, a chronic wound is physiologically impaired. The main problem in wound management is that the majority of wounds are colonized with microbes, whereas this does not mean that all wounds will be infected. In this review, we address the problems that clinicians face to manage while treat acute and chronic wounds. Moreover, we demonstrate the pathophysiology, etiology, prognosis and microbiology of wounds. We further introduce the state of art in pharmaceutical technology field as part of wound management aiming to assist health professionals to overcome the current implications on wound assessment. In addition, authors review researches which included the use of gels and dermal films as wound healing agents. It can be said that natural and synthetic drugs or carriers provide promising solutions in order to meet the wound management standards. However, are the current strategies as desirable as medical society wish?

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Section: Biomaterials For Wound Managementmentioning

confidence: 99%

Recent trends on wound management: New therapeutic choices based on polymeric carriers

Okur

Karantas

Şenyiğit

et al. 2020

Asian Journal of Pharmaceutical Sciences

227

115

View full text Add to dashboard Cite

show abstract

“…In the spectrum ( Figure 5 ), chitosan exhibited two sharp peaks at 2θ = 10° and 2θ = 25°, indicating the regular crystal lattice of chitosan (crystal form I and crystal from II, respectively) [ 54 ]. As compared to the XRD pattern of chitosan [ 55 ], there was a noticeable change in the peaks of thiolated chitosan ( Figure 5 ), suggesting the assimilation of –SH– groups in the chemical structure of chitosan and indicating a change in the crystallinity, which might be due to alterations in the inter polymeric atomic density [ 30 ]. The characteristic peak of chitosan was decreased and shifted to 2θ = 23.5° in thiolated chitosan, that is due to the reduction in number of free amino groups and reduction in intra molecular and intermolecular hydrogen bonding, which led to the lower crystallinity of TC [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Thiolated Chitosan Microneedle Patch of Levosulpiride from Fabrication, Characterization to Bioavailability Enhancement Approach

et al. 2022

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In this study, a first attempt has been made to deliver levosulpiride transdermally through a thiolated chitosan microneedle patch (TC-MNP). Levosulpiride is slowly and weakly absorbed from the gastrointestinal tract with an oral bioavailability of less than 25% and short half-life of about 6 h. In order to enhance its bioavailability, levosulpiride-loaded thiolated chitosan microneedle patches (LS-TC-MNPs) were fabricated. Firstly, thiolated chitosan was synthesized and characterized by nuclear magnetic resonance (1HNMR) spectroscopy, attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, differential scanning calorimetry (DSC), and X-ray diffraction (XRD). Thiolated chitosan has been used in different drug delivery systems; herein, thiolated chitosan has been used for the transdermal delivery of LS. LS-TC-MNPs were fabricated from different concentrations of thiolated chitosan solution. Furthermore, the levosulpiride-loaded thiolated chitosan microneedle patch (LS-TC-MNP) was characterized by FTIR spectroscopic analysis, scanning electron microscopy (SEM) study, penetration ability, tensile strength, moisture content, patch thickness, and elongation test. LS-TC-MNP fabricated with 3% thiolated chitosan solution was found to have the best tensile strength, moisture content, patch thickness, elongation, drug-loading efficiency, and drug content. Thiolated chitosan is biodegradable, nontoxic and has good absorption and swelling in the skin. LS-TC-MNP-3 consists of 100 needles in 10 rows each with 10 needles. The length of each microneedle was 575 μm; they were pyramidal in shape, with sharp pointed ends and a base diameter of 200 µm. The microneedle patch (LS-TC-MNP-3) resulted in-vitro drug release of 65% up to 48 h, ex vivo permeation of 63.6%, with good skin biocompatibility and enhanced in-vivo pharmacokinetics (AUC = 986 µg/mL·h, Cmax = 24.5 µg/mL) as compared to oral LS dispersion (AUC = 3.2 µg/mL·h, Cmax = 0.5 µg/mL). Based on the above results, LS-TC-MNP-3 seems to be a promising strategy for enhancing the bioavailability of levosulpiride.

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“…One explanation for the relatively low value obtained for WVPF is that gelatin and PVA are hydrophilic materials and interact strongly with water molecules, causing a reduction in the transmission of water vapor through the hydrogel film, because part of the water can be retained in the hydrogel. 58,59 This result can be confirmed by the swelling test, where it is perceived the affinity of the hydrogel film with water, since, in just 2 minutes of the assay, it absorbed 65% of water.…”

Section: Optimization Of the Hydrogel Film Formulationmentioning

confidence: 61%

Gelatin/poly(vinyl alcohol) based hydrogel film – A potential biomaterial for wound dressing: Experimental design and optimization followed by rotatable central composite design

2021

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The development of hydrogel films for biomedical applications is interesting due to their characteristics. Hydrogel films based on gelatin and poly(vinyl alcohol) (PVA) are developed and characterized using a rotatable central composite design. The optimized hydrogel film is obtained by the function desirability of the Statistica® software and is also characterized by swelling kinetics, oxygen permeability, adhesiveness, TGA, DSC, and XRD. The results of the experimental design show that gelatin and PVA concentrations have a significant influence on the response variables, and the exposure doses to UV light show no significant effect. The optimized hydrogel film is elastic, presents good mechanical resistance and swelling capacity in water and exudate solution, is permeable to oxygen, and is capable of adjusting itself and maintains contact close to the skin. In this way, considering all the properties evaluated, the optimized film has characteristics suitable for biomedical applications as wound dressings.

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Development and characterization of chitosan-based hydrogels as wound dressing materials

Cited by 66 publications

References 51 publications

Recent trends on wound management: New therapeutic choices based on polymeric carriers

Recent trends on wound management: New therapeutic choices based on polymeric carriers

Thiolated Chitosan Microneedle Patch of Levosulpiride from Fabrication, Characterization to Bioavailability Enhancement Approach

Gelatin/poly(vinyl alcohol) based hydrogel film – A potential biomaterial for wound dressing: Experimental design and optimization followed by rotatable central composite design

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