Development and characterization of microemulsion based topical gel of essential oil of clove (Syzygium aromaticum) for superficial fungal infections

Gandhi, Jeet; Suthar, Disha; Patel, Hetal; Shelat, Pragna K.; Parejiya, Punit B.

doi:10.1007/s13596-020-00462-6

Cited by 22 publications

(20 citation statements)

References 29 publications

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“…Therefore, the ME-loaded MCNE11 formulation may be a suitable substitute to deliver drug at therapeutic concentration without causing any adverse reactions. 45 …”

Section: Resultsmentioning

confidence: 99%

Antifungal Cationic Nanoemulsion Ferrying Miconazole Nitrate with Synergism to Control Fungal Infections:In Vitro,Ex Vivo, andIn VivoEvaluations

et al. 2022

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This study aimed to deliver a cationic nanoemulsion carrying miconazole nitrate (MCN) to control fungal infections using excipients for synergism. Peceol (oil) and labrasol (surfactant) were selected based on maximum solubility and zone of inhibition values against Candida albicans and Aspergillus niger . Optimized MCNE11 was evaluated [size, zeta potential, % entrapment efficiency (%EE), % transmittance, viscosity, refractive index, extrudability, polydispersity (PDI), morphology, and pH]. An in vitro drug release study was conducted for comparison between DS (drug suspension) and MNE11. In vitro hemolysis was studied at two different concentrations (0.625 and 2.5 μg/mL). Permeation profiles were generated using rat skin. A Draize test was conducted using rabbit to negate irritability issues. Finally, a stability test of MCNE11 was conducted for 12 months. The results showed that MCNE11 (cationic) was the most optimized in term of size, %EE, and PDI. The drug release from MCNE11 was higher compared to DS but comparable to MNE11 (anionic), suggesting no impact of the imposed cationic charge on the release behavior. Moreover, permeation parameters of MCNE11 were significantly ( p < 0.05) greater than MNE11, which may be attributed to the combined impact of size (low), surfactant (for reversible changes), and electrostatic interaction (nanoglobules–skin surface). Thus, stable MCN11 possessing high %EE (89.8%), low size (145 nm), maximum flux (5.7 ± 0.1 μg/cm 2 /h), high drug deposition (932.7 ± 41.6 μg/cm 2 ), optimal viscosity (44.17 ± 0.8 cP), low PDI (0.21), optimal zeta potential (+28.1 mV), and low hemolysis can be promising alternatives to conventional cream to control resistant and recurring types of fungal infections.

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“…Therefore, the ME-loaded MCNE11 formulation may be a suitable substitute to deliver drug at therapeutic concentration without causing any adverse reactions. 45 …”

Section: Resultsmentioning

confidence: 99%

Antifungal Cationic Nanoemulsion Ferrying Miconazole Nitrate with Synergism to Control Fungal Infections:In Vitro,Ex Vivo, andIn VivoEvaluations

et al. 2022

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“…The percent transmittance of the system was checked by measuring transmittance at 650 nm with distilled water as a reference [ 17 , 43 ] by a UV spectrophotometer (UV2600i, Shimadzu, Kyoto, Japan).…”

Section: Methodsmentioning

confidence: 99%

Surface Modification of Curcumin Microemulsions by Coupling of KLVFF Peptide: A Prototype for Targeted Bifunctional Microemulsions

et al. 2022

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Curcumin is one of the most promising natural therapeutics for use against Alzheimer’s disease. The major limitations of curcumin are its low oral bioavailability and difficulty in permeating the blood–brain barrier. Therefore, designing a delivery system of curcumin to overcome its limitations must be employed. KLVFF, a peptide known as an amyloid blocker, was used in this study as a targeting moiety to develop a targeted drug delivery system. A prototype of transnasal KLVFF conjugated microemulsions containing curcumin (KLVFF-Cur-ME) for the nose-to-brain delivery was fabricated. The KLVFF-Cur-ME was developed by a titration method. A conjugation of KLVFF was performed through a carbodiimide reaction, and the conjugation efficiency was confirmed by FTIR and DSC technique. KLVFD-Cur-ME was characterized for the drug content, globule size, zeta potential, and pH. A transparent and homogeneous KLVFF-Cur-ME is achieved with a drug content of 80.25% and a globule size of 76.1 ± 2.5 nm. The pH of KLVFF-Cur-ME is 5.33 ± 0.02, indicating non-irritation to nasal tissues. KLVFD-Cur-ME does not show nasal ciliotoxicity. An ex vivo diffusion study revealed that KLVFF-Cur-ME partitions the porcine nasal mucosa through diffusion, following the Higuchi model. This investigation demonstrates the successful synthesis of a bifunctional KLVFF-Cur-ME as a novel prototype to deliver anti-Aβ aggregation via an intranasal administration.

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“…TEM is used to determine the morphological and structural framework of the colloidal suspension. The morphology of optimized NE was characterized by TEM analysis using TECHNAI 200 kV TEM (Fei, Electron Optics) [24]. The sample was prepared by diluting 100 times with water and placing it on a copper TEM grid with LO-NE colloidal solution and 2% Phosphotungstic acid.…”

Section: Transmission Electron Microscopy (Tem)mentioning

confidence: 99%

“…The sample was prepared by diluting 100 times with water and placing it on a copper TEM grid with LO-NE colloidal solution and 2% Phosphotungstic acid. The slide was observed on an electron microscope [24] and staining it.…”

Section: Transmission Electron Microscopy (Tem)mentioning

confidence: 99%

Synthesis and Characterization of <i>Citrus limonum</i> Essential Oil Based Nanoemulsion and Its Enhanced Antioxidant Activity with Stability for Transdermal Application

Kaur¹,

Pancham²,

Kaur³

et al. 2020

JBNB

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Lemon oil (LO), also known as Citrus limonum is a highly volatile essential oil (EO) with potential therapeutic properties like anti-oxidative, anti-proliferative, anti-fungal and anti-cancerous. However, the efficacy of LO is limited due to its physiological factors such as high volatility, poor stability (particularly sensitive to sunlight) and quick degradability upon exposure. To overcome these challenges, we formulated lemon oil loaded nanoemulsion system (LO-NE) (oil-in-water), using aqueous titration method. The formulation comprised of lemon oil (LO), Tween 80 and ethanol as oil, surfactant and co-surfactant phases respectively. The existence zone of NE was established by constructing pseudo-ternary phase diagrams using different concentrations of LO, surfactant and co-surfactant (S mix ). The quantitative estimation of LO was performed using a high throughput gas chromatography, revealing the presence of various compounds like Limonene, Alpha-Pinene and Linalyl acetate followed by the estimation of total phenolics and flavonoid content. The characterization of LO-NE indicated the particle size of 60 ± 2.5 nm along with the polydispersity index of 0.125 and zeta potential of −14.9 mV. The size range of the NE particles dispersed in the colloidal system was further verified by TEM micrograph which shows size range between 46.2 -104.7 nm. All the anti-oxidant assays outcomes exhibited the higher activity of LO-NE in comparison to LO alone with lower IC 50 values. The release kinetics statistical data showed that LO-NE had a sustained release and followed the Higuchi's model How to cite this paper:

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Development and characterization of microemulsion based topical gel of essential oil of clove (Syzygium aromaticum) for superficial fungal infections

Cited by 22 publications

References 29 publications

Antifungal Cationic Nanoemulsion Ferrying Miconazole Nitrate with Synergism to Control Fungal Infections:In Vitro,Ex Vivo, andIn VivoEvaluations

Antifungal Cationic Nanoemulsion Ferrying Miconazole Nitrate with Synergism to Control Fungal Infections:In Vitro,Ex Vivo, andIn VivoEvaluations

Surface Modification of Curcumin Microemulsions by Coupling of KLVFF Peptide: A Prototype for Targeted Bifunctional Microemulsions

Synthesis and Characterization of <i>Citrus limonum</i> Essential Oil Based Nanoemulsion and Its Enhanced Antioxidant Activity with Stability for Transdermal Application

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Development and characterization of microemulsion based topical gel of essential oil of clove (Syzygium aromaticum) for superficial fungal infections

Cited by 22 publications

References 29 publications

Antifungal Cationic Nanoemulsion Ferrying Miconazole Nitrate with Synergism to Control Fungal Infections:In Vitro,Ex Vivo, andIn VivoEvaluations

Antifungal Cationic Nanoemulsion Ferrying Miconazole Nitrate with Synergism to Control Fungal Infections:In Vitro,Ex Vivo, andIn VivoEvaluations

Surface Modification of Curcumin Microemulsions by Coupling of KLVFF Peptide: A Prototype for Targeted Bifunctional Microemulsions

Synthesis and Characterization of &lt;i&gt;Citrus limonum&lt;/i&gt; Essential Oil Based Nanoemulsion and Its Enhanced Antioxidant Activity with Stability for Transdermal Application

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Synthesis and Characterization of <i>Citrus limonum</i> Essential Oil Based Nanoemulsion and Its Enhanced Antioxidant Activity with Stability for Transdermal Application