Development and characterization of pH responsive sodium alginate hydrogel containing metal-phenolic network for anthocyanin delivery

Mao, Shuifang; Ren, Yanming; Chen, Shiguo; Liu, Donghong; Tian, Jinhu; Ye, Xingqian

doi:10.1016/j.carbpol.2023.121234

Cited by 37 publications

(5 citation statements)

References 75 publications

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“…Current research has shown that pH-responsiveness was a very important characteristic of metal–phenolic complexes. 42,43 Eu@B-UiO-66 exhibited about 84% eugenol release rate under different pH conditions, which was not pH-responsive (Fig. 3b).…”

Section: Resultsmentioning

confidence: 98%

pH-responsive on-demand release of eugenol from metal–organic frameworks for synergistic bacterial killing

Wang,

Li,

et al. 2024

Dalton Trans.

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Section: Resultsmentioning

confidence: 98%

pH-responsive on-demand release of eugenol from metal–organic frameworks for synergistic bacterial killing

Wang,

Li,

et al. 2024

Dalton Trans.

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“…The drug release curve of drug-loaded hydrogel is shown in Figure f. The cumulative release rate of drug-loaded hydrogel increases with the increase of environmental pH value, which may be due to the increase of the force between HPMC molecular chains under acidic conditions, resulting in the aggregation of cellulose, resulting in the slow diffusion and release rate of curcumin. , The maximum cumulative release rate of Cur-Car-IL@Ilo hydrogel at pH 5.0, 7.4, and 9.0 for 24 h was 57.39, 73.28, and 86.4%, respectively. As the concentration increases, the drug loading capacity of Cur-Car-IL@Ilo hydrogel gradually increases and reaches a maximum value of 196.5 mg g –1 , with an encapsulation efficiency of 93.27% (Figures g and S5).…”

Section: Results and Discussionmentioning

confidence: 99%

Curcumin-Based Ionic Liquid Hydrogel for Topical Transdermal Delivery of Curcumin To Improve Its Therapeutic Effect on the Psoriasis Mouse Model

Lu,

Zhong,

Zhang

et al. 2024

ACS Appl. Mater. Interfaces

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Psoriasis is a systemic, recurrent, chronic autoimmune skin disease. However, psoriasis drugs have poor skin permeability and high toxicity, resulting in low bioavailability and affecting their clinical application. In this study, we propose a curcumin-based ionic liquid hydrogel loaded with ilomastat (Cur-Car-IL@Ilo hydrogel), which can effectively maintain the sustained release of drugs and improve the skin permeability of drugs. We used a model of imiquimod-induced psoriasis and demonstrated that local application of Cur-Car-IL@Ilo hydrogel can improve skin lesions in mice with significantly reduced expression levels of inflammatory factors, matrix metalloproteinase 8, and collagen-I. The expressions of iron death-related proteins SLC7A11 and ASL4 were significantly decreased after treatment with Cur-Car-IL@Ilo hydrogel. Flora analysis showed that the content of anaerotruncus, proteus, and UCG-009 bacteria in the gut of psoriatic mice increased. The levels of paludicola, parabacteroides, prevotellaceae_UCG-001, escherichia-shigella, and aerococcus decreased, and the levels of some of the above bacteria tended to be normal after treatment. Therefore, the curcumin-based ionic liquid hydrogel can be used as a multifunctional, nonirritating, noninvasive, and highly effective percutaneous treatment of psoriasis.

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“…Using Thermo-Gravimetric Analysis (TGA), several studies have shown that the addition of anthocyanins to polymeric matrices or the encapsulation of anthocyanins in a polymer provides greater stability with respect to pure compounds [ 82 , 83 , 84 ].…”

Section: Anthocyanin-loaded Polymers: Preparation and Characterizatio...mentioning

confidence: 99%

Anthocyanin-Loaded Polymers as Promising Nature-Based, Responsive, and Bioactive Materials

Rosales-Murillo,

Sánchez-Bodón,

Hernández Olmos

et al. 2024

Polymers

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Anthocyanins are a specific group of molecules found in nature that have recently received increasing attention due to their interesting biological and colorimetric properties that have been successfully applied in several fields such as food preservation and biomedicine. Consequently, reviews devoted to a general overview of these flavonoids have proliferated in recent years. Meanwhile, the incorporation of anthocyanins into polymeric systems has become an interesting strategy to widen the applicability of these molecules and develop new smart and functional polymers in the above cited areas. However, anthocyanin-based polymers have been scarcely reviewed in the literature. Accordingly, this review aims to be a systematic summary of the most recent approaches for the incorporation of anthocyanins into macro-, micro-, or nanostructured polymers. Moreover, this work describes the fundamentals of the applicability of smart anthocyanin-based polymers and offers an updated review of their most interesting applications as sensors, biological regulators, and active materials.

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Development and characterization of pH responsive sodium alginate hydrogel containing metal-phenolic network for anthocyanin delivery

Cited by 37 publications

References 75 publications

pH-responsive on-demand release of eugenol from metal–organic frameworks for synergistic bacterial killing

pH-responsive on-demand release of eugenol from metal–organic frameworks for synergistic bacterial killing

Curcumin-Based Ionic Liquid Hydrogel for Topical Transdermal Delivery of Curcumin To Improve Its Therapeutic Effect on the Psoriasis Mouse Model

Anthocyanin-Loaded Polymers as Promising Nature-Based, Responsive, and Bioactive Materials

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