Development and characterization of <scp>pH</scp>‐responsive polyethylene glycol‐co‐poly(methacrylic acid) polymeric network system for colon target delivery of oxaliplatin: Its acute oral toxicity study

Barkat, Kashif; Ahmad, Mahmood; Minhas, Muhammad Usman; Khalid, Ikrima; Nasir, Bushra

doi:10.1002/adv.21840

Cited by 63 publications

(39 citation statements)

References 49 publications

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“…Our results were well support by the previous findings of Ullah et al [ 40 ] while studying chitosan-based hydrogels for polyoxometalate and conducted oral toxicity studies in rabbits. Similarly, our results were also in close relationship with the previous study performed by Barkat et al [ 41 ] while examining the synthesis PEG-based hydrogel for controlled delivery of oxiplatin (OXP) and carried out safety evaluation studies in rabbits.…”

Section: Resultssupporting

confidence: 90%

“…A commonly used initiator is ammonium persulfate (APS) [ 29 ] that was used in this study. Moreover, N ′, N ′-methylene bis-acrylamide (MBA) was employed as a cross-linker, which is the most important component of hydrogel that converts water-soluble polymers to insolubilized polymeric hydrogels [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization and Safety Evaluation of Sericin-Based Hydrogels for Controlled Delivery of Acyclovir

et al. 2021

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Conventional formulations of antiviral drug acyclovir have various limitations such as low bioavailability. The current study was aimed at developing polymeric matrices for the controlled delivery of acyclovir using sericin as polymer and acrylic acid (AA) as a monomer. The free radical polymerization technique was used for hydrogel formulation. Briefly, sericin was chemically cross-linked with acrylic acid. N′-N′-methylene bis-acrylamide (MBA) and ammonium persulfate (APS) were used as cross-linker and initiator, respectively. FTIR spectra showed that acyclovir was successfully loaded into sericin hydrogel. SEM micrographs revealed that the outer surface was solid-like and smooth. According to DSC thermograms, the developed polymeric network was thermally stable. Amorphous nature of acyclovir was observed in XRD. The pH of medium and reactants’ concentration affected swelling dynamics and acyclovir release pattern. In addition, drug release occurred through a diffusion-controlled process. Sericin hydrogel suspension was well tolerable up to 3800 mg/kg of rabbits' body weight. Haematology and serum chemistry results were well within the range signifying normal liver and kidney functions. Similarly, histopathology slides of the rabbit’s vital organs were also in normal condition without causing any histopathological change. It was concluded from the findings that sericin-co-AA polymeric matrices are ideal for the pH-dependent delivery of acyclovir.

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Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Safety Evaluation of Sericin-Based Hydrogels for Controlled Delivery of Acyclovir

et al. 2021

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“…A sample was taken at specific time intervals and then analyzed by UV–vis-spectrophotometer (U-5100, 3J2-0014, Tokyo, Japan) at wavelength of 260 nm. The same quantity of fresh buffer was added into the dissolution medium as that which was taken in order to maintain a sink condition [ 61 ].…”

Section: Methodsmentioning

confidence: 99%

Fabrication and Characterization of Diclofenac Sodium Loaded Hydrogels of Sodium Alginate as Sustained Release Carrier

Suhail

Khan

Rosenholm

et al. 2021

Gels

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The aim of the current study was to fabricate naturally derived polymer based hydrogels for controlled release of diclofenac sodium (DS) for a long duration of time. In this research work, sodium alginate-co-poly(2-acrylamido-2-methyl propane sulphonic acid) (SA-co-poly(AMPS)) hydrogels were prepared by the free radical polymerization technique, where sodium alginate (SA) and 2-acrylamido-2-methyl propane sulphonic acid (AMPS) were used as the polymer and monomer while ammonium peroxodisulfate (APS) and N,N′-Methylene bisacrylamide (MBA) were used as the initiator and cross-linker, respectively. A swelling study was performed to determine the swelling index of developed hydrogels in both acidic (pH 1.2) and basic (pH 7.4) media and pH-independent swelling was observed due to the presence of AMPS. An in vitro release study was conducted to evaluate the percentage of drug released, and a high release of the drug was found at the higher pH of 7.4. Sol–gel analysis was performed to analyze the crosslinked and uncrosslinked part of the hydrogels, and results showed a rise in gel fraction as the composition of SA, AMPS and MBA increased while the sol fraction decreased and vice versa. This work demonstrated a potential for sustained delivery of diclofenac sodium by employing various concentration of SA, AMPS and MBA.

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“…The degradation half-life of polymer is (t 1/2 = 430 °C) whereas the degradation half-life of SPSPAA hydrogels is (t 1/2 = 480 °C), which indicates that the developed system is thermally more stable then unreacted pure polymer and attributed to strong cross-linking between SPS and AA. Barkat and his co-workers prepared PEG 4000-based hydrogels and found higher thermal stability of the fabricated network compared to pure polymer [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

Preparation, Characterization, Swelling Potential, and In-Vitro Evaluation of Sodium Poly(Styrene Sulfonate)-Based Hydrogels for Controlled Delivery of Ketorolac Tromethamine

et al. 2021

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The objective of the current study work was to fabricate sodium poly(styrene sulfonate-co-poly acrylic acid) (SPSPAA) hydrogels by using a free radical co-polymerization method for controlled delivery of ketorolac tromethamine (KT). Polymer (sodium poly(styrene sulfonate) (SPS) polymerized with monomer acrylic acid (AA) in the presence of initiator ammonium peroxodisulfate (APS) and cross-linker N′,N′-Methylene bisacrylamide (MBA). Different combinations of polymer, cross-linker and monomer, were employed for development of polymeric hydrogels. Various studies such as sol-gel, drug loading, dynamic swelling, and drug release studies were carried out to know the sol and gel portion of SPSPAA, swelling behavior of hydrogels at different pH media (1.2 and 7.4), quantification of drug loaded by fabricated hydrogels, and amount release of KT at pH 1.2 and 7.4. Higher dynamic swelling was found at pH 7.4 compared to pH 1.2, and as a result, greater percent release of drug was perceived at pH 7.4. Thermal stability, crystallinity, confirmation of functional groups and development of a new polymeric system, and surface morphology were evaluated via Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC), Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) respectively. The results showed that the present work could be used as a potential candidate for controlled delivery of KT.

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Development and characterization of pH‐responsive polyethylene glycol‐co‐poly(methacrylic acid) polymeric network system for colon target delivery of oxaliplatin: Its acute oral toxicity study

Cited by 63 publications

References 49 publications

Synthesis, Characterization and Safety Evaluation of Sericin-Based Hydrogels for Controlled Delivery of Acyclovir

Synthesis, Characterization and Safety Evaluation of Sericin-Based Hydrogels for Controlled Delivery of Acyclovir

Fabrication and Characterization of Diclofenac Sodium Loaded Hydrogels of Sodium Alginate as Sustained Release Carrier

Preparation, Characterization, Swelling Potential, and In-Vitro Evaluation of Sodium Poly(Styrene Sulfonate)-Based Hydrogels for Controlled Delivery of Ketorolac Tromethamine

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