Development and characterization of thermosensitive hydrogels based on poly(<i>N</i>‐isopropylacrylamide) and calcium alginate

Petruš̆̌̌̌ić, Stojanka; Lewandowski, Maryline; Giraud, Stéphane; Jovančić, Petar; Bugarski, Branko; Ostojić, Sanja; Končar, Vladan

doi:10.1002/app.35122

Cited by 35 publications

(22 citation statements)

References 46 publications

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“…This is because the hydrogen bonding interaction between N-H and −COO − groups makes the C=O bond stronger by disturbing the symmetry of carboxylate ion, which confirms the strong hydrogen bond interaction between the constituents of the blend (9,26,27). In the case of INZ, peaks between 3,100-3,000 cm −1 and 2,990-2,900 cm −1 correspond to respective asymmetric and symmetric stretching vibrations of the C-H bond, while the N-H stretching vibration is observed at 3,247 cm −1 .…”

Section: Ftir Spectral Analysismentioning

confidence: 73%

Novel pH- and Temperature-Responsive Blend Hydrogel Microspheres of Sodium Alginate and PNIPAAm-g-GG for Controlled Release of Isoniazid

2012

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Abstract. This paper reports the preparation and characterization of novel pH-and thermo-responsive blend hydrogel microspheres of sodium alginate (NaAlg) and poly(N-isopropylacrylamide)(PNIPAAm)-grafted-guar gum (GG) i.e., PNIPAAm-g-GG by emulsion cross-linking method using glutaraldehyde (GA) as a cross-linker. Isoniazid (INZ) was chosen as the model antituberculosis drug to achieve encapsulation up to 62%. INZ has a plasma half-life of 1.5 h, whose release was extended up to 12 h. Fourier transform infrared spectroscopy was used to confirm the grafting reaction and chemical stability of INZ during the encapsulation. Differential scanning calorimetry was used to investigate the drug's physical state, while powder X-ray diffraction confirmed the molecular level dispersion of INZ in the matrix. Scanning electron microscopy confirmed varying surface morphologies of the drug-loaded microspheres. Temperature-and pH-responsive nature of the blend hydrogel microspheres were investigated by equilibrium swelling, and in vitro release experiments were performed in pH1.2 and pH7.4 buffer media at 37°C as well as at 25°C. Kinetics of INZ release was analyzed by Ritger-Peppas empirical equation to compute the diffusional exponent parameter (n), whose value ranged between 0.27 and 0.58, indicating the release of INZ follows a diffusion swelling controlled release mechanism.

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Section: Ftir Spectral Analysismentioning

confidence: 73%

Novel pH- and Temperature-Responsive Blend Hydrogel Microspheres of Sodium Alginate and PNIPAAm-g-GG for Controlled Release of Isoniazid

2012

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“…The combination of CA with cross-linked PNIPAAm results in hydrogel with a more regular structure, adequate mechanical properties, and swelling/deswelling rate when compared to the structure of each of its components [31]. The phenomenon is explained by the formation of a porous structure within the hydrogels in the presence of ionized alginate during the polymerization process.…”

Section: Strategies For Synthesis Of Pnipaam-based Hydrogelsmentioning

confidence: 97%

Novel Synthesis Pathways for PNIPAAm-Based Hydrogels and Their Application in Thermosensitive Textiles

Jovančić

Petruš̆̌̌̌ić

Molina

2014

Handbook of Smart Textiles

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The research focus is lately directed towards the development of the thermosensitive textiles with advanced functionalities. As sources of inspiration for a progress in the field of these innovative materials, stimuli-sensitive polymer engineering, plasma surface engineering, and nanotechnology have been extensively explored. In this work, the polymerization methods for synthesis of Poly(N-isopropylacrylamide), PNIPAAm-based hydrogels, incorporating natural biopolymers (chitosan and b-cyclodextrin), for achieving dual temperature/pH sensitivity and improvement of relevant loading capacity towards specific guest molecules are outlined. These PNIPAAm-based hydrogels are of great interest for biomedical applications (transdermal drug delivery, cell encapsulation, wound dressing, tissue repair, etc.) and intelligent stimuli-sensitive textile coatings for moisture regain control, antimicrobial properties, water and/or oil repellency, and fragrance release. The strategies for synthesis of PNIPAAm-based hydrogels (macro and micro forms) and their proper integration onto textiles through the plasma surface modification, graft polymerization, and coatings are discussed. Novel possibilities for creating hydrogels based on atmospheric plasma polymerization of NIPAAm monomers in liquids have alos been reported. Plasma polymerization in liquids demonstrated a great technological potential given that it may be performed without the use of chemical initiators and even without cross-linking agents, offering multiple advantages over the conventional hydrothermal polymerization methods. Further research on adequate chemical and physical structures of PNIPAAm-based hydrogels and methods of their applications in textiles could boost a progress in the domain of smart textiles, implying novel performances and end uses.

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“…In a similar vein, alginate-based thermosensitive PNIPAAm IPNs have shown similar properties at around 40 °C, which is explained by the reduced chain mobility in the networks. [42,43]…”

Section: Water Uptakementioning

confidence: 99%

Synthesis and Characterization of Thermosensitive Poly(N‐Vinyl Caprolactam)‐Grafted‐Aminated Alginate Hydrogels

Durkut

Elçin

2019

Macro Chemistry & Physics

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Thermosensitive hydrogels are characterized by the drastic and reversible change of their physical properties with temperature. Herein is presented the development of a thermosensitive poly(N‐vinylcaprolactam)‐grafted‐aminated alginate (PNVCL‐g‐Alg‐NH2) having a temperature‐dependent phase transition close to physiological temperature. The hybrid copolymer is formed through the combinational use of chemical and physical methods, that is, carbodiimide chemistry, and ionotrophic gelation by calcium cations. PNVCL‐g‐Alg‐NH2 exhibits a phase transition at ≈35 °C, and temperature‐dependent water uptake. Copolymerization with PNVCL leads to a decrease in the water uptake of aminated alginate, while improving its thermal stability. Model protein (bovine serum albumin) release from PNVCL‐g‐Alg‐NH2 scaffolds indicates a higher rate of release below the lower critical solution temperature (LCST) than that of the above, owing to the fact that PNVCL chains collapse at above the LCST and forms a more compact network. In vitro cytotoxicity and hemocompatibility analyses confirm that PNVCL‐g‐Alg‐NH2 scaffolds are basically non‐cytotoxic and non‐hemolytic.

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Development and characterization of thermosensitive hydrogels based on poly(N‐isopropylacrylamide) and calcium alginate

Cited by 35 publications

References 46 publications

Novel pH- and Temperature-Responsive Blend Hydrogel Microspheres of Sodium Alginate and PNIPAAm-g-GG for Controlled Release of Isoniazid

Novel pH- and Temperature-Responsive Blend Hydrogel Microspheres of Sodium Alginate and PNIPAAm-g-GG for Controlled Release of Isoniazid

Novel Synthesis Pathways for PNIPAAm-Based Hydrogels and Their Application in Thermosensitive Textiles

Synthesis and Characterization of Thermosensitive Poly(N‐Vinyl Caprolactam)‐Grafted‐Aminated Alginate Hydrogels

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