Development and Comparison of Cross-Linking and Non-Crosslinking Probe-Gold Nanoparticle Hybridization Assays for Direct Detection of Unamplified Bovine Viral Diarrhea Virus-RNA
Abstract:Background: Bovine viral diarrhea virus (BVDV) is a major economic disease that has been spread in most countries. In addition to vaccination, one of the main ways to control the disease and prevent it from spreading is to detect and cull infected animals, especially those with persistent infection (PI). We developed and compared two colorimetric biosensor assays based on probe-modified gold nanoparticles (AuNPs) to detect BVDV. Specific probes were designed to detect the 5ʹ untranslated region of BVDV-RNA. Th… Show more
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