Development and comprehensive greenness assessment for MEKC and HPTLC methods for simultaneous estimation of sertaconazole with two co-formulated preservatives in pharmaceutical dosage forms

Elbordiny, Haydi S.; Elonsy, Sohila M.; Daabees, Hoda G.; Belal, Tarek S.

doi:10.1016/j.scp.2021.100580

Cited by 20 publications

(12 citation statements)

References 18 publications

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“…This was due to the usage of less green organic solvents in our proposed method including methanol, chloroform, toluene, and glacial acetic acid. However, the proposed method was considered acceptably green [22,23] (Table 8). The second tool used to evaluate the method's greenness was NEMI where the greenness profile of a four-field pictogram has been used.…”

Section: Greenness Evaluation Of the Proposed Hptlc Methods And Compa...mentioning

confidence: 99%

“…In addition, suspensions, dirty or turbid samples can be directly applied without pre-cleaning [20,21]. In addition, the degree of the greenness of the proposed HPTLC method was evaluated using different green analytical chemistry (GAC) metrics including analytical Eco-scale Assessment (ESA) [22,23], National Environmental Method Index (NEMI) [24], Analytical GREEnness (AGREE) [25], and Green Analytical Procedure Index (GAPI) pictograms [26].…”

Section: Introductionmentioning

confidence: 99%

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An eco‐friendly multi‐analyte high‐performance thin layer chromatographic densitometric determination of amoxicillin, metronidazole, and famotidine in their ternary mixtures and simulated gastric juice: A promising protocol for eradicating Helicobacter pylori

Ragab

Maher

Tarek

et al. 2022

J of Separation Science

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Gastrointestinal tract disorders constitute a heavy burden to healthcare providers. To eradicate Helicobacter pylori infection, different triple therapy protocols have been proposed. Among which are combinations of proton pump inhibitors (e.g., omeprazole), histamine‐2 receptor antagonists (e.g., famotidine), along with antibiotics (e.g., amoxicillin). In this work, a sensitive and accurate high‐performance thin‐layer chromatographic method was developed for the simultaneous determination of amoxicillin, metronidazole, and famotidine in bulk powder and laboratory‐prepared combined‐tablet mixtures. Complete separation of the cited compounds was achieved using pre‐coated silica gel plates with a mixture of methanol:chloroform:toluene:water:glacial acetic acid (5:2:1.5:0.5:0.1 v/v/v/v/v) as the mobile phase. The method was fully validated as per the international conference of harmonization guidelines. Good linearity, a correlation coefficient of 0.9991, was obtained in the concentration ranges 0.1–1.6 μg/band (amoxicillin), 0.1–0.9 μg/band (metronidazole), and 0.1–0.9 μg/band (famotidine). Since the method allowed the determination of the three compounds in combined tablets with a high degree of selectivity, accuracy, precision, with cost‐effectiveness, it could be used for regular quality control. Moreover, the applicability of the proposed method was extended to the determination of the ternary mixture in simulated gastric juice. Method greenness was assessed using different green metrics.

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Section: Greenness Evaluation Of the Proposed Hptlc Methods And Compa...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An eco‐friendly multi‐analyte high‐performance thin layer chromatographic densitometric determination of amoxicillin, metronidazole, and famotidine in their ternary mixtures and simulated gastric juice: A promising protocol for eradicating Helicobacter pylori

Ragab

Maher

Tarek

et al. 2022

J of Separation Science

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“…As per our endeavour in the field of sustainability and green analytical chemistry 21–23 together with the GMP, two green, rapid, and stability-indicating methodologies MEKC and HPLC were implemented for the neat analysis of NMV and RIT. The devised methods are regarded as the first stability-indicating attempt for NMV-RIT simultaneous estimation.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, HPLC is considered the gold standard apparatus in all quality control and research units, offering rapid and sensitive means of separation of different samples. 21 As per our endeavour in the eld of sustainability and green analytical chemistry [21][22][23] together with the GMP, two green, rapid, and stability-indicating methodologies MEKC and HPLC were implemented for the neat analysis of NMV and RIT. The devised methods are regarded as the rst stability-indicating attempt for NMV-RIT simultaneous estimation.…”

Section: Introductionmentioning

confidence: 99%

Tailoring two white chromatographic platforms for simultaneous estimation of ritonavir-boosted nirmatrelvir in their novel pills: degradation, validation, and environmental impact studies

Elbordiny,

Alzoman,

Maher

et al. 2023

RSC Adv.

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“…From an ecological standpoint, the fluorescence spectroscopic technique is more eco-friendly and greener since it uses less energy during operation, uses fewer solvents and reagents, and generates less waste as a result. [22][23][24][25][26][27][28][29] These advantages enhanced its use as a quick, affordable, and green analytical instrument for quality control and research laboratories.…”

mentioning

confidence: 99%

Green sensitive spectrofluorimetric determination of pemetrexed as antineoplastic drug: Application in pharmaceutical dosage forms and spiked human plasma

et al. 2022

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A recent antineoplastic medication is pemetrexed, this medicine is now being developed and produced on a large scale, thus approaches for quality control are urgently needed. Spectrofluorimetric guidelines for the simple estimation of pemetrexed were validated. Pemetrexed's assay depends on observations of its native fluorescence at wavelengths 275/450 nm and pH 4. The proposed approach was also used to identify the examined drug in both its formulation and in human plasma that had been spiked.

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Development and comprehensive greenness assessment for MEKC and HPTLC methods for simultaneous estimation of sertaconazole with two co-formulated preservatives in pharmaceutical dosage forms

Cited by 20 publications

References 18 publications

An eco‐friendly multi‐analyte high‐performance thin layer chromatographic densitometric determination of amoxicillin, metronidazole, and famotidine in their ternary mixtures and simulated gastric juice: A promising protocol for eradicating Helicobacter pylori

An eco‐friendly multi‐analyte high‐performance thin layer chromatographic densitometric determination of amoxicillin, metronidazole, and famotidine in their ternary mixtures and simulated gastric juice: A promising protocol for eradicating Helicobacter pylori

Tailoring two white chromatographic platforms for simultaneous estimation of ritonavir-boosted nirmatrelvir in their novel pills: degradation, validation, and environmental impact studies

Green sensitive spectrofluorimetric determination of pemetrexed as antineoplastic drug: Application in pharmaceutical dosage forms and spiked human plasma

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